Witz, 2008, Yin-yang activities and vicious cycles in the tumor microenvironment., Cancer Res, 68, 9, 10.1158/0008-5472.CAN-07-2917
Mantovani, 2008, Cancer-related inflammation., Nature, 454, 436, 10.1038/nature07205
Murdoch, 2008, The role of myeloid cells in the promotion of tumour angiogenesis., Nat Rev Cancer, 8, 618, 10.1038/nrc2444
Lewis, 2006, Distinct role of macrophages in different tumor microenvironments., Cancer Res, 66, 605, 10.1158/0008-5472.CAN-05-4005
Pollard, 2004, Tumour-educated macrophages promote tumour progression and metastasis., Nat Rev Cancer, 4, 71, 10.1038/nrc1256
Mantovani, 1992, The origin and function of tumor-associated macrophages., Immunol Today, 13, 265, 10.1016/0167-5699(92)90008-U
Lin, 2006, Macrophages regulate the angiogenic switch in a mouse model of breast cancer., Cancer Res, 66, 11238, 10.1158/0008-5472.CAN-06-1278
Lin, 2001, Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy., J Exp Med, 193, 727, 10.1084/jem.193.6.727
Bingle, 2002, The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies., J Pathol, 196, 254, 10.1002/path.1027
Dave, 2004, Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells., N Engl J Med, 351, 2159, 10.1056/NEJMoa041869
Rosenwald, 2002, The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma., N Engl J Med, 346, 1937, 10.1056/NEJMoa012914
Taylor, 2003, Monocyte heterogeneity and innate immunity., Immunity, 19, 2, 10.1016/S1074-7613(03)00178-X
Mosser, 2008, Exploring the full spectrum of macrophage activation., Nat Rev Immunol, 8, 958, 10.1038/nri2448
Gordon, 2003, Alternative activation of macrophages., Nat Rev Immunol, 3, 23, 10.1038/nri978
Mantovani, 2002, Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes., Trends Immunol, 23, 549, 10.1016/S1471-4906(02)02302-5
Mantovani, 2004, The chemokine system in diverse forms of macrophage activation and polarization., Trends Immunol, 25, 677, 10.1016/j.it.2004.09.015
Van Ginderachter, 2006, Classical and alternative activation of mononuclear phagocytes: picking the best of both worlds for tumor promotion., Immunobiology, 211, 487, 10.1016/j.imbio.2006.06.002
Biswas, 2008, Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms., J Immunol, 180, 2011, 10.4049/jimmunol.180.4.2011
Stout, 2004, Functional plasticity of macrophages: reversible adaptation to changing microenvironments., J Leukoc Biol, 76, 509, 10.1189/jlb.0504272
Kusmartsev, 2005, STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion., J Immunol, 174, 4880, 10.4049/jimmunol.174.8.4880
Tsai, 2007, Macrophages from irradiated tumors express higher levels of iNOS, arginase-I and COX-2, and promote tumor growth., Int J Radiat Oncol Biol Phys, 68, 499, 10.1016/j.ijrobp.2007.01.041
Balkwill, 2001, Inflammation and cancer: back to Virchow?, Lancet, 357, 539, 10.1016/S0140-6736(00)04046-0
Sinha, 2005, Interleukin-13-regulated M2 macrophages in combination with myeloid suppressor cells block immune surveillance against metastasis., Cancer Res, 65, 11743, 10.1158/0008-5472.CAN-05-0045
Sica, 2000, Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages., J Immunol, 164, 762, 10.4049/jimmunol.164.2.762
Curiel, 2004, Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival., Nat Med, 10, 942, 10.1038/nm1093
Bronte, 2001, Tumor-induced immune dysfunctions caused by myeloid suppressor cells., J Immunother, 24, 431, 10.1097/00002371-200111000-00001
Nagaraj, 2008, Tumor escape mechanism governed by myeloid-derived suppressor cells., Cancer Res, 68, 2561, 10.1158/0008-5472.CAN-07-6229
Sinha, 2007, Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response., J Immunol, 179, 977, 10.4049/jimmunol.179.2.977
Sinha, 2007, Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells., Cancer Res, 67, 4507, 10.1158/0008-5472.CAN-06-4174
Bronte, 2003, L-arginine metabolism in myeloid cells controls T-lymphocyte functions., Trends Immunol, 24, 302, 10.1016/S1471-4906(03)00132-7
Kusmartsev, 2005, Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells., J Immunol, 175, 4583, 10.4049/jimmunol.175.7.4583
Kusmartsev, 2004, Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species., J Immunol, 172, 989, 10.4049/jimmunol.172.2.989
Huang, 2006, Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host., Cancer Res, 66, 1123, 10.1158/0008-5472.CAN-05-1299
Gallina, 2006, Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells., J Clin Invest, 116, 2777, 10.1172/JCI28828
Yang, 2004, Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis., Cancer Cell, 6, 409, 10.1016/j.ccr.2004.08.031
Sica, 2007, Altered macrophage differentiation and immune dysfunction in tumor development., J Clin Invest, 117, 1155, 10.1172/JCI31422
Hoffmann, 2003, Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities., EMBO J, 22, 5530, 10.1093/emboj/cdg534
Kawai, 2007, Signaling to NF-kappaB by Toll-like receptors., Trends Mol Med, 13, 460, 10.1016/j.molmed.2007.09.002
Balkwill, 2004, Cancer and the chemokine network., Nat Rev Cancer, 4, 540, 10.1038/nrc1388
O'Neill, 2006, How Toll-like receptors signal: what we know and what we don't know., Curr Opin Immunol, 18, 3, 10.1016/j.coi.2005.11.012
Colonna, 2007, TLR pathways and IFN-regulatory factors: to each its own., Eur J Immunol, 37, 306, 10.1002/eji.200637009
Kawai, 2005, Toll-like receptor downstream signaling., Arthritis Res Ther, 7, 12, 10.1186/ar1469
Ozato, 2002, Toll-like receptor signaling and regulation of cytokine gene expression in the immune system., Biotechniques, 66, 10.2144/Oct0208
Ohmori, 2001, Requirement for STAT1 in LPS-induced gene expression in macrophages., J Leukoc Biol, 69, 598, 10.1189/jlb.69.4.598
Vakkila, 2008, Coordinate NF-kappaB and STAT1 activation promotes development of myeloid type 1 dendritic cells., Scand J Immunol, 67, 260, 10.1111/j.1365-3083.2007.02068.x
Taniguchi, 2001, IRF family of transcription factors as regulators of host defense., Annu Rev Immunol, 19, 623, 10.1146/annurev.immunol.19.1.623
Shuai, 2003, Regulation of JAK-STAT signalling in the immune system., Nat Rev Immunol, 3, 900, 10.1038/nri1226
Jiang, 2000, IL-4/IL-13 signaling beyond JAK/STAT., J Allergy Clin Immunol, 105, 1063, 10.1067/mai.2000.107604
Donnelly, 1999, The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes., J Interferon Cytokine Res, 19, 563, 10.1089/107999099313695
O'Shea, 2004, A new modality for immunosuppression: targeting the JAK/STAT pathway., Nat Rev Drug Discov, 3, 555, 10.1038/nrd1441
Greten, 2004, IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer., Cell, 118, 285, 10.1016/j.cell.2004.07.013
Karin, 2005, NF-kappaB: linking inflammation and immunity to cancer development and progression., Nat Rev Immunol, 5, 749, 10.1038/nri1703
Luedde, 2007, Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma., Cancer Cell, 11, 119, 10.1016/j.ccr.2006.12.016
Maeda, 2005, IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis., Cell, 121, 977, 10.1016/j.cell.2005.04.014
Pikarsky, 2004, NF-kappaB functions as a tumour promoter in inflammation-associated cancer., Nature, 431, 461, 10.1038/nature02924
Lawrence, 2007, Cancer: sex, cytokines, and cancer., Science, 317, 51, 10.1126/science.1146052
Balkwill, 2005, Smoldering and polarized inflammation in the initiation and promotion of malignant disease., Cancer Cell, 7, 211, 10.1016/j.ccr.2005.02.013
Lin, 2007, A cytokine-mediated link between innate immunity, inflammation, and cancer., J Clin Invest, 117, 1175, 10.1172/JCI31537
Dinapoli, 1996, The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduce expression of the inducible nitric oxide synthase gene., J Exp Med, 183, 1323, 10.1084/jem.183.4.1323
Biswas, 2006, A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation)., Blood, 107, 2112, 10.1182/blood-2005-01-0428
Hagemann, 2006, Ovarian cancer cells polarize macrophages toward a tumor-associated phenotype., J Immunol, 176, 5023, 10.4049/jimmunol.176.8.5023
Hagemann, 2008, “Re-educating” tumor-associated macrophages by targeting NF-kappaB., J Exp Med, 205, 1261, 10.1084/jem.20080108
Saccani, 2006, p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance., Cancer Res, 66, 11432, 10.1158/0008-5472.CAN-06-1867
Bohuslav, 1998, Regulation of an essential innate immune response by the p50 subunit of NF-kappaB., J Clin Invest, 102, 1645, 10.1172/JCI3877
Colombo, 2005, Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion., Cancer Res, 65, 9113, 10.1158/0008-5472.CAN-05-2714
Guiducci, 2005, Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection., Cancer Res, 65, 3437, 10.1158/0008-5472.CAN-04-4262
Swann, 2008, Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis., Proc Natl Acad Sci U S A, 105, 652, 10.1073/pnas.0708594105
Fong, 2008, An antiinflammatory role for IKKbeta through the inhibition of “classical” macrophage activation., J Exp Med, 205, 1269, 10.1084/jem.20080124
Hagemann, 2005, Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK., J Immunol, 175, 1197, 10.4049/jimmunol.175.2.1197
Kawai, 2005, Pathogen recognition with Toll-like receptors., Curr Opin Immunol, 17, 338, 10.1016/j.coi.2005.02.007
Thomas, 2006, Contribution of interferon-beta to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharide., J Biol Chem, 281, 31119, 10.1074/jbc.M604958200
Tomczak, 2003, NF-kappa B is required within the innate immune system to inhibit microflora-induced colitis and expression of IL-12 p40., J Immunol, 171, 1484, 10.4049/jimmunol.171.3.1484
Balkwill, 1987, Evidence for tumour necrosis factor/cachectin production in cancer., Lancet, 2, 1229, 10.1016/S0140-6736(87)91850-2
Nawroth, 1988, Tumor necrosis factor/cachectin-induced intravascular fibrin formation in meth A fibrosarcomas., J Exp Med, 168, 637, 10.1084/jem.168.2.637
Wu, 2004, Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18., J Immunol, 172, 3243, 10.4049/jimmunol.172.5.3243
Ghassabeh, 2006, Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo during different pathologies., Blood, 108, 575, 10.1182/blood-2005-04-1485
Mantovani, 2005, Macrophage polarization comes of age., Immunity, 23, 344, 10.1016/j.immuni.2005.10.001
Elgert, 1998, Tumor-induced immune dysfunction: the macrophage connection., J Leukoc Biol, 64, 275, 10.1002/jlb.64.3.275
Tu, 2008, Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice., Cancer Cell, 14, 408, 10.1016/j.ccr.2008.10.011
Andersson, 2001, Novel candidate genes for atherosclerosis are identified by representational difference analysis-based transcript profiling of cholesterol-loaded macrophages., Pathobiology, 69, 304, 10.1159/000064637
Thomas, 2000, Critical role of C/EBPdelta and C/EBPbeta factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1beta in articular chondrocytes., Eur J Biochem, 267, 6798, 10.1046/j.1432-1033.2000.01778.x
Wadleigh, 2000, Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages., J Biol Chem, 275, 6259, 10.1074/jbc.275.9.6259
Klimp, 2001, Expression of cyclooxygenase-2 and inducible nitric oxide synthase in human ovarian tumors and tumor-associated macrophages., Cancer Res, 61, 7305
Banerjee, 2006, Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells., Proc Natl Acad Sci U S A, 103, 3274, 10.1073/pnas.0511113103
Lawrence, 2001, Possible new role for NF-kappaB in the resolution of inflammation., Nat Med, 7, 1291, 10.1038/nm1201-1291
Tsan, 2004, Endogenous ligands of Toll-like receptors., J Leukoc Biol, 76, 514, 10.1189/jlb.0304127
Kuang, 2007, Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes., Blood, 110, 587, 10.1182/blood-2007-01-068031
Chen, 2007, Toll-like receptors in inflammation, infection and cancer., Int Immunopharmacol, 7, 1271, 10.1016/j.intimp.2007.05.016
Vaupel, 2006, Impact of hemoglobin levels on tumor oxygenation: the higher, the better?, Strahlenther Onkol, 182, 63, 10.1007/s00066-006-1543-7
Burke, 2003, Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy., Am J Pathol, 163, 1233, 10.1016/S0002-9440(10)63483-9
Murdoch, 2004, Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues., Blood, 104, 2224, 10.1182/blood-2004-03-1109
Rius, 2008, NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha., Nature, 453, 807, 10.1038/nature06905