Alterations in Brain Norepinephrine Metabolism Induced by Environmental Stimuli Previously Paired with Inescapable Shock

American Association for the Advancement of Science (AAAS) - Tập 209 Số 4461 - Trang 1138-1140 - 1980
Geraldine Cassens1, Mark Roffman1, Alvin Kuruc1, Paul J. Orsulak1, Joseph J. Schildkraut1
1Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston 02115.

Tóm tắt

Footshock stress produced an immediate increase in brain concentrations of 3-methoxy-4-hydroxyphenylglycol sulfate (MHPG-SO 4 ), a major metabolite of the neurotransmitter norepinephrine, in the rat brain. Twenty-four hours after footshock stress, when concentrations had returned to baseline, increases in MHPG-SO 4 and emotional behavior could be elicited by previously neutral environmental stimuli that had been paired with the stress.

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Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 209 Số 4461

1138-1140

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