Renin inhibitors Improvements in the stability and biological activity of small peptides containing novel Leu‐Val replacements

10.1021/jm00392a015 Stein H.H., 1985, Fed. Proc., 44, 1363 10.1016/0003-2697(78)90563-8 10.1016/0014-5793(87)80834-7 10.1016/0006-291X(87)90627-9 Luly J.R., 1988, J. Med. Chem. Luly J.R. and Plattner J.J. (1986) European Patent Application 0229667. Luly J.R. Plattner J.J. Rosenberg S.H. and Fung A. (1986) European Patent Application 0189203. Luly J.R., 1987, Abstracts of the 193rd American Chemical Society Meeting, Division of Medicinal Chemistry, Denver, April 5–10, 1987 Luly J.R., 1987, Proceedings of the Tenth American Peptide Symposium Kleinert H.D., 1988, Hypertension 10.1246/cl.1985.1041 ‘Statine‐like’ refers to compounds which have an absolute stereochemistry of the carbon bearing the hydroxyl group like that of statine (4S‐amino‐3S‐hydroxy‐6‐methylheptanoic acid). This will avoid possible confusion brought on by the ‘S/R’ stereochemical convention [14]. For example the stereochemistry of C2 of inhibitor 4a is statine‐like but of theRconfiguration. 1976, Pure Appl. Chem., 45, 13