Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation

Blood - Tập 123 - Trang 3664-3671 - 2014
Philippe Armand1, Haesook T. Kim2, Brent R. Logan3,4, Zhiwei Wang3, Edwin P. Alyea1, Matt E. Kalaycio5, Richard T. Maziarz6, Joseph H. Antin1, Robert J. Soiffer1, Daniel J. Weisdorf7, J. Douglas Rizzo3, Mary M. Horowitz3, Wael Saber3
1Department of Medical Oncology and
2Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
3Center for International Blood and Marrow Transplant Research, Department of Medicine
4Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI
5Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic, Cleveland, OH
6Center for Hematologic Malignancies, Knight Cancer Institute, Oregon Health & Science University, Portland, OR
7Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN

Tóm tắt

Key Points The DRI successfully stratified patients in a very large allogeneic transplantation registry cohort. The DRI was refined by using this cohort to build a more inclusive and conditioning intensity–independent index.

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