Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation

Blood - Tập 123 - Trang 3664-3671 - 2014
Philippe Armand1, Haesook T. Kim2, Brent R. Logan3,4, Zhiwei Wang3, Edwin P. Alyea1, Matt E. Kalaycio5, Richard T. Maziarz6, Joseph H. Antin1, Robert J. Soiffer1, Daniel J. Weisdorf7, J. Douglas Rizzo3, Mary M. Horowitz3, Wael Saber3
1Department of Medical Oncology and
2Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
3Center for International Blood and Marrow Transplant Research, Department of Medicine
4Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI
5Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic, Cleveland, OH
6Center for Hematologic Malignancies, Knight Cancer Institute, Oregon Health & Science University, Portland, OR
7Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN

Tóm tắt

Key Points The DRI successfully stratified patients in a very large allogeneic transplantation registry cohort. The DRI was refined by using this cohort to build a more inclusive and conditioning intensity–independent index.

Tài liệu tham khảo

Weisdorf, 2008, Classification of HLA-matching for retrospective analysis of unrelated donor transplantation: revised definitions to predict survival., Biol Blood Marrow Transplant, 14, 748, 10.1016/j.bbmt.2008.04.003 Sorror, 2005, Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT., Blood, 106, 2912, 10.1182/blood-2005-05-2004 Armand, 2012, A disease risk index for patients undergoing allogeneic stem cell transplantation., Blood, 120, 905, 10.1182/blood-2012-03-418202 Slack, 2013, Reduced toxicity conditioning and allogeneic stem cell transplantation in adults using fludarabine, carmustine, melphalan, and antithymocyte globulin: outcomes depend on disease risk index but not age, comorbidity score, donor type, or human leukocyte antigen mismatch., Biol Blood Marrow Transplant, 19, 1167, 10.1016/j.bbmt.2013.05.001 Thanarajasingam, 2013, Outcome and prognostic factors for patients who relapse after allogeneic hematopoietic stem cell transplantation., Biol Blood Marrow Transplant, 19, 1713, 10.1016/j.bbmt.2013.09.011 Horowitz, 2008, The role of registries in facilitating clinical research in BMT: examples from the Center for International Blood and Marrow Transplant Research., Bone Marrow Transplant, 42, S1, 10.1038/bmt.2008.101 Armand, 2012, Classifying cytogenetics in patients with acute myelogenous leukemia in complete remission undergoing allogeneic transplantation: a Center for International Blood and Marrow Transplant Research study., Biol Blood Marrow Transplant, 18, 280, 10.1016/j.bbmt.2011.07.024 Armand, 2010, Multicenter validation study of a transplantation-specific cytogenetics grouping scheme for patients with myelodysplastic syndromes., Bone Marrow Transplant, 45, 877, 10.1038/bmt.2009.253 Harrell, 1984, Regression modelling strategies for improved prognostic prediction., Stat Med, 3, 143, 10.1002/sim.4780030207 Armand, 2007, Impact of cytogenetics on outcome of de novo and therapy-related AML and MDS after allogeneic transplantation., Biol Blood Marrow Transplant, 13, 655, 10.1016/j.bbmt.2007.01.079 Grimwade, 2010, Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials., Blood, 116, 354, 10.1182/blood-2009-11-254441 Greenberg, 1997, International scoring system for evaluating prognosis in myelodysplastic syndromes., Blood, 89, 2079, 10.1182/blood.V89.6.2079 Parimon, 2006, A risk score for mortality after allogeneic hematopoietic cell transplantation., Ann Intern Med, 144, 407, 10.7326/0003-4819-144-6-200603210-00007 Anasetti, 2012, Peripheral-blood stem cells versus bone marrow from unrelated donors., N Engl J Med, 367, 1487, 10.1056/NEJMoa1203517 Mohty, 2010, Reduced-intensity versus conventional myeloablative conditioning allogeneic stem cell transplantation for patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation., Blood, 116, 4439, 10.1182/blood-2010-02-266551 Postow, 2011, Philadelphia chromosome is not an adverse prognostic factor in acute lymphoblastic leukemia after myeloablative allogeneic hematopoietic stem cell transplantation [abstract]., Biol Blood Marrow Transplant, 17, S244, 10.1016/j.bbmt.2010.12.276 Gooley, 2010, Reduced mortality after allogeneic hematopoietic-cell transplantation., N Engl J Med, 363, 2091, 10.1056/NEJMoa1004383