Analysis of FOXO1 mutations in diffuse large B-cell lymphoma

Blood - Tập 121 Số 18 - Trang 3666-3674 - 2013
Diane L. Trinh1,2, David W. Scott3, Ryan D. Morin4,5, María Méndez-Lago1, Jianghong An1, Steven J.M. Jones1,4,5, Andrew J. Mungall1, Yongjun Zhao1, Jacqueline E. Schein1, Christian Steidl3,6, Joseph M. Connors3, Randy D. Gascoyne3,6, Marco A. Marra1,2
1Canada’s Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada
2Department of Medical Genetics, University of British Columbia, Vancouver, Canada
3Centre for Lymphoid Cancer, Department of Experimental Therapeutics, British Columbia Cancer Agency, Vancouver, Canada
4Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
5Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada; and
6Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada

Tóm tắt

Key Points Recurrent mutations in FOXO1 affect the DNA binding domain and the T24 phosphorylation site, which disrupt interactions with 14-3-3. Presence of FOXO1 mutations is associated with decreased OS, particularly in DLBCL patients of the low-risk R-IPI categories.

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