In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

Environmental Health Perspectives - Tập 118 Số 4 - Trang 485-492 - 2010
Richard Judson1, Keith A. Houck1, Robert J. Kavlock1, Thomas B. Knudsen1, Matthew T. Martin1, Holly M. Mortensen1, David M. Reif1, Daniel M. Rotroff1, Imran Shah1, Ann M. Richard1, David J. Dix1
1National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

10.1016/j.reprotox.2008.10.001

10.1111/j.1432-1033.1988.tb14026.x

10.1016/0041-008X(88)90026-9

Centers for Disease Control and Prevention, 2005, Third National Report on Human Exposure to Environmental Chemicals

10.1002/bdrb.20147

10.1126/science.1154619

Curado MP, 2007, Cancer Incidence in Five Continents, Vol IX, IARC Sci Publ, 160, 1

10.1016/j.mce.2009.02.017

10.1080/10408440802209804

10.1093/toxsci/kfl103

FDA, 2008, Guidance for Industry, Diabetes Mellitus: Developing Drugs and Therapeutic Biologics for Treatment and Prevention

10.1073/pnas.0701361104

10.1016/0016-5085(87)90273-3

10.1289/ehp.0900758

International Programme on Chemical Safety. 2005. The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification: 2004 Available: http://www.inchem.org/documents/pds/pdsother/class.pdf [accessed 23 November 2009].

10.1038/bjc.1983.268

10.1289/ehp.0800168

10.3748/wjg.14.5945

10.1093/nar/30.1.42

10.1111/j.1539-6924.2008.01168.x

Kemp CJ, 1989, Genetic variation in liver tumor susceptibility, plasma testosterone levels, and androgen receptor binding in six inbred strains of mice, Cancer Res, 49, 5044

10.1080/713608372

10.1016/j.reprotox.2009.03.016

10.1016/0020-711X(92)90294-B

10.1158/1078-0432.CCR-05-0798

10.1081/GNC-120038005

10.1016/j.taap.2003.11.031

10.1289/ehp.0800074

10.1093/toxsci/kfp080

10.1289/ehp.01109437

Morris HP, 1956, Influence of sex and sex hormones on development of hepatomas and other hepatic lesions in strain AX C rats ingesting 2-diacetylaminofluorene, J Natl Cancer Inst, 16, 927

National Research Council, 2007, Toxicity Testing in the 21st Century: A Vision and a Strategy

10.1093/toxsci/kfm255

10.1002/hep.22637

10.4161/auto.6822

10.1016/j.taap.2006.08.011

U.S. EPA (Environmental Protection Agency). 2008a. TOXCST: Research Chemical Inventory for EPA’s ToxCast Program: Structure-Index File Available: http://www.epa.gov/ncct/dsstox/sdf_toxcst.html [accessed 8 August 2008].

U.S. EPA (Environmental Protection Agency). 2008b. ToxCast Program Available: http://www.epa.gov/ncct/toxcast/ [accessed 8 August 2008].

U.S. EPA (Environmental Protection Agency). 2008c. EPA Toxicity Reference Database Available: http://www.epa.gov/NCCT/toxrefdb/ [accessed 4 June 2009].

U.S. EPA (Environmental Protection Agency). 2009. Pesticide Reregistration Status Available: http://www.epa.gov/oppsrrd1/reregistration/status.htm [accessed 4 June 2009].

10.1111/j.1365-2605.2007.00861.x