Human CNS cultures exposed to HIV-1 gp120 reproduce dendritic injuries of HIV-1-associated dementia
Tóm tắt
HIV-1-associated dementia remains a common subacute to chronic central nervous system degeneration in adult and pediatric HIV-1 infected populations. A number of viral and host factors have been implicated including the HIV-1 120 kDa envelope glycoprotein (gp120). In human post-mortem studies using confocal scanning laser microscopy for microtubule-associated protein 2 and synaptophysin, neuronal dendritic pathology correlated with dementia. In the present study, primary human CNS cultures exposed to HIV-1 gp120 at 4 weeks in vitro suffered gliosis and dendritic damage analogous to that described in association with HIV-1-associated dementia.
Tài liệu tham khảo
Ellis RJ, Deutsch R, Heaton RK, Marcotte TD, McCutchan JA, Nelson JA, Abramson I, Thal LJ, Atkinson JH, Wallace MR, Grant I: Neurocognitive impairment is an independent risk factor for death in HIV infection. San Diego HIV Neurobehavioral Research Center Group. Arch Neurol. 1997, 54: 416-424.
Clifford DB: Human immunodeficiency virus-associated dementia. Arch Neurol. 2000, 57: 321-324. 10.1001/archneur.57.3.321.
Kaul M, Garden GA, Lipton SA: Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature. 2001, 410: 988-994. 10.1038/35073667.
Sacktor N, McDermott MP, Marder K, Schifitto G, Selnes OA, McArthur JC, Stern Y, Albert S, Palumbo D, Kieburtz K, De Marcaida JA, Cohen B, Epstein L: HIV-associated cognitive impairment before and after the advent of combination therapy. J Neurovirol. 2002, 8: 136-142.
McArthur JC, Hoover DR, Bacellar H, Miller EN, Cohen BA, Becker JT, Graham NM, McArthur JH, Selnes OA, Jacobson LP: Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS Cohort Study. Neurology. 1993, 43: 2245-2252.
Dore GJ, Correll PK, Li Y, Kaldor JM, Cooper DA, Brew BJ: Changes to AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS. 1999, 13: 1249-1253. 10.1097/00002030-199907090-00015.
Ferrando S, van Gorp W, McElhiney M, Goggin K, Sewell M, Rabkin J: Highly active antiretroviral treatment in HIV infection: benefits for neuropsychological function. AIDS. 1998, 12: F65-F70. 10.1097/00002030-199808000-00002.
Sacktor NC, Lyles RH, Skolasky RL, Anderson DE, McArthur JC, McFarlane G, Selnes OA, Becker JT, Cohen B, Wesch J, Miller EN: Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men. Multicenter AIDS Cohort Study (MACS). Neurology. 1999, 52: 1640-1647.
Major EO, Rausch D, Marra C, Clifford D: HIV-associated dementia. Science. 2000, 288: 440-442. 10.1126/science.288.5465.439d.
Lipton SA: Treating AIDS dementia. Science. 1997, 276: 1629-1630. 10.1126/science.276.5319.1629b.
Walsh K, Thompson W, Megyesi J, Wiley CA, Hammond R: HIV-/AIDS Neuropathology in a canadian teaching centre. Can J Neurol Sci. 2003, in press:
Masliah E, Ge N, Achim CL, Hansen LA, Wiley CA: Selective neuronal vulnerability in HIV encephalitis. J Neuropathol Exp Neurol. 1992, 51: 585-593.
Everall IP, Glass JD, McArthur J, Spargo E, Lantos P: Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia. Acta Neuropathol (Berl). 1994, 88: 538-544. 10.1007/s004010050196.
Masliah E, Achim CL, Ge N, DeTeresa R, Terry RD, Wiley CA: Spectrum of human immunodeficiency virus-associated neocortical damage. Ann Neurol. 1992, 32: 321-329.
Everall IP, Heaton RK, Marcotte TD, Ellis RJ, McCutchan JA, Atkinson JH, Grant I, Mallory M, Masliah E: Cortical synaptic density is reduced in mild to moderate human immunodeficiency virus neurocognitive disorder. HNRC Group. HIV Neurobehavioral Research Center. Brain Pathol. 1999, 9: 209-217.
Dreyer EB, Kaiser PK, Offermann JT, Lipton SA: HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science. 1990, 248: 364-367.
Kaiser PK, Offermann JT, Lipton SA: Neuronal injury due to HIV-1 envelope protein is blocked by anti-gp120 antibodies but not by anti-CD4 antibodies. Neurology. 1990, 40: 1757-1761.
Lipton SA, Sucher NJ, Kaiser PK, Dreyer EB: Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron. 1991, 7: 111-118. 10.1016/0896-6273(91)90079-F.
Catani MV, Corasaniti MT, Navarra M, Nistico G, Finazzi-Agro A, Melino G: gp120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors. J Neurochem. 2000, 74: 2373-2379. 10.1046/j.1471-4159.2000.0742373.x.
Kaul M, Lipton SA: Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proc Natl Acad Sci U S A. 1999, 96: 8212-8216. 10.1073/pnas.96.14.8212.
Pandey V, Bolsover SR: Immediate and neurotoxic effects of HIV protein gp120 act through CXCR4 receptor. Biochem Biophys Res Commun. 2000, 274: 212-215. 10.1006/bbrc.2000.3113.
Catani MV, Corasaniti MT, Ranalli M, Amantea D, Litovchick A, Lapidot A, Melino G: The Tat antagonist neomycin B hexa-arginine conjugate inhibits gp-120-induced death of human neuroblastoma cells. J Neurochem. 2003, 84: 1237-1245. 10.1046/j.1471-4159.2003.01620.x.
Nath A, Haughey NJ, Jones M, Anderson C, Bell JE, Geiger JD: Synergistic neurotoxicity by human immunodeficiency virus proteins Tat and gp120: protection by memantine. Ann Neurol. 2000, 47: 186-194. 10.1002/1531-8249(200002)47:2<186::AID-ANA8>3.3.CO;2-V.
Corder EH, Robertson K, Lannfelt L, Bogdanovic N, Eggertsen G, Wilkins J, Hall C: HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy. Nat Med. 1998, 4: 1182-1184. 10.1038/2677.
Zemlyak I, Brooke SM, Sapolsky RM: Protection against gp120-induced neurotoxicity by an array of estrogenic steroids. Brain Res. 2002, 958: 272-276. 10.1016/S0006-8993(02)03558-8.
Brooke SM, Sapolsky RM: Effects of glucocorticoids in the gp120-induced inhibition of glutamate uptake in hippocampal cultures. Brain Res. 2003, 972: 137-141. 10.1016/S0006-8993(03)02517-4.
Scorziello A, Florio T, Bajetto A, Schettini G: Intracellular signalling mediating HIV-1 gp120 neurotoxicity. Cell Signal. 1998, 10: 75-84. 10.1016/S0898-6568(97)00093-4.
Bruce-Keller AJ: Microglial-neuronal interactions in synaptic damage and recovery. J Neurosci Res. 1999, 58: 191-201. 10.1002/(SICI)1097-4547(19991001)58:1<191::AID-JNR17>3.3.CO;2-5.
Giulian D, Vaca K, Noonan CA: Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science. 1990, 250: 1593-1596.
Giulian D, Wendt E, Vaca K, Noonan CA: The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes. Proc Natl Acad Sci U S A. 1993, 90: 2769-2773.
Chao CC, Hu S, Molitor TW, Shaskan EG, Peterson PK: Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol. 1992, 149: 2736-2741.
Boje KM, Arora PK: Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 1992, 587: 250-256. 10.1016/0006-8993(92)91004-X.
Brooke SM, Sapolsky RM: Glucocorticoid exacerbation of gp120 neurotoxicity: role of microglia. Exp Neurol. 2002, 177: 151-158. 10.1006/exnr.2002.7956.
Dugas N, Lacroix C, Kilchherr E, Delfraissy JF, Tardieu M: Role of CD23 in astrocytes inflammatory reaction during HIV-1 related encephalitis. 2001, 15: 96-107.
Pozzoli G, Tringali G, Dello Russo C., Vairano M, Preziosi P, Navarra P: HIV-1 Gp120 protein modulates corticotropin releasing factor synthesis and release via the stimulation of its mRNA from the rat hypothalamus in vitro: involvement of inducible nitric oxide synthase. J Neuroimmunol. 2001, 118: 268-276. 10.1016/S0165-5728(01)00351-4.
Howard SA, Nakayama AY, Brooke SM, Sapolsky RM: Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures. Exp Neurol. 1999, 158: 164-170. 10.1006/exnr.1999.7080.
Brandimarti R, Khan MZ, Fatatis A, Meucci O: Regulation of cell cycle proteins by chemokine receptors: A novel pathway in human immunodeficiency virus neuropathogenesis?. J Neurovirol. 2004, 10 (Suppl 1): 108-112. 10.1080/13550280490268287.
Hammond RR, Iskander S, Achim CL, Hearn S, Nassif J, Wiley CA: A reliable primary human CNS culture protocol for morphological studies of dendritic and synaptic elements. J Neurosci Methods. 2002, 118: 189-198. 10.1016/S0165-0270(02)00126-7.
Martin FC, Wiley CA: A serum-free, pyruvate-free medium that supports neonatal neural/glial cultures. J Neurosci Res. 1995, 41: 246-258.
White MG, Hammond RR, Sanders VJ, Bonaroti EA, Mehta AP, Wang G, Wiley CA, Achim CL: Neuron-enriched second trimester human cultures: growth factor response and in vivo graft survival. Cell Transplant. 1999, 8: 59-73.
Masliah E, Heaton RK, Marcotte TD, Ellis RJ, Wiley CA, Mallory M, Achim CL, McCutchan JA, Nelson JA, Atkinson JH, Grant I: Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC Group. The HIV Neurobehavioral Research Center. Ann Neurol. 1997, 42: 963-972.
McArthur JC, Sacktor N, Selnes O: Human immunodeficiency virus-associated dementia. Semin Neurol. 1999, 19: 129-150.
Adle-Biassette H, Chretien F, Wingertsmann L, Hery C, Ereau T, Scaravilli F, Tardieu M, Gray F: Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage. Neuropathol Appl Neurobiol. 1999, 25: 123-133. 10.1046/j.1365-2990.1999.00167.x.
Dawson VL, Dawson TM, Uhl GR, Snyder SH: Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proc Natl Acad Sci U S A. 1993, 90: 3256-3259.
Cai L, Cherian MG, Iskander S, Leblanc M, Hammond RR: Metallothionein induction in human CNS in vitro: neuroprotection from ionizing radiation. Int J Radiat Biol. 2000, 76: 1009-1017. 10.1080/09553000050051025.