Akio Kawamura1, Masao Saitoh2, Motoki Yonekawa1, Takashi Horie1, Hiroko Ohizumi2, Tohru Tamaki1, Kazutaka Kukita1, Jun‐ichi Meguro1
1Department of Surgery and
2Department of Gastroenterology, Sapporo Hokuyu Hospital, Sapporo, Japan
Tóm tắt
Abstract: Leukocytapheresis (LCAP) is widely used for the treatment of immunological diseases. We studied a new treatment of LCAP using a nonwoven polyester fiber filter. In a basic study, 30–70% of leukocytes were removed. Also, 30–68% of the leukocyte subsets were removed. Sixteen inflammatory bowel disease (IBD) patients, mainly with ulcerative colitis (UC), were treated by this method. Their cytokine activity was normalized in the filter and in the peripheral blood. Eleven of 12 patients with UC were induced to remission. Four patients with Crohn's disease (CD) exhibited improvement. The LCAP using a nonwoven polyester fiber filter was very efficient for treating the patients with IBD. Also, it will be a very useful treatment for immunological diseases and extracorporeal immunomodulation.
