The 2016 revision of the World Health Organization classification of lymphoid neoplasms

Blood - Tập 127 - Trang 2375-2390 - 2016
Steven H. Swerdlow1, Elias Campo2, Stefano A. Pileri3, Nancy Lee Harris4, Harald Stein5, Reiner Siebert6, Ranjana Advani7, Michele Ghielmini8, Gilles A. Salles9, Andrew D. Zelenetz10, Elaine S. Jaffe11
1Division of Hematopathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA;
2Department of Pathology, Hospital Clinic, University of Barcelona, August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain;
3Haematopathology Unit, European Institute of Oncology, Milan, and Department of Experimental, Diagnostic and Specialty Medicine, Bologna University Medical School, Bologna, Italy;
4Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA;
5Pathodiagnostik, Berlin, Germany
6Institute of Human Genetics, Christian Albrechts University Kiel, Kiel, Germany
7Division of Oncology, Department of Medicine, Stanford University, Stanford, CA
8Department of Medical Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland;
9Department of Hematology, Hospices Civils de Lyon, and Université Claude Bernard Lyon-1, Lyon, France;
10Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY; and
11Hematopathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD

Tóm tắt

Abstract A revision of the nearly 8-year-old World Health Organization classification of the lymphoid neoplasms and the accompanying monograph is being published. It reflects a consensus among hematopathologists, geneticists, and clinicians regarding both updates to current entities as well as the addition of a limited number of new provisional entities. The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies. The major changes are reviewed with an emphasis on the most important advances in our understanding that impact our diagnostic approach, clinical expectations, and therapeutic strategies for the lymphoid neoplasms.

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