The 2016 revision of the World Health Organization classification of lymphoid neoplasms

Swerdlow Swerdlow, WHO classification of tumours of haematopoietic and lymphoid tissues. Campo, 2011, The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications., Blood, 117, 5019, 10.1182/blood-2011-01-293050 Nieto, 2009, Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach., Blood, 114, 33, 10.1182/blood-2009-01-197368 Landgren, 2009, B-cell clones as early markers for chronic lymphocytic leukemia., N Engl J Med, 360, 659, 10.1056/NEJMoa0806122 Rawstron, 2010, Different biology and clinical outcome according to the absolute numbers of clonal B-cells in monoclonal B-cell lymphocytosis (MBL)., Cytometry B Clin Cytom, 78, S19, 10.1002/cyto.b.20533 Vardi, 2013, Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL., Blood, 121, 4521, 10.1182/blood-2012-12-471698 Morabito, 2013, Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: a comparison of cellular, cytogenetic, molecular, and clinical features., Clin Cancer Res, 19, 5890, 10.1158/1078-0432.CCR-13-0622 Xochelli, 2014, Clonal B-cell lymphocytosis exhibiting immunophenotypic features consistent with a marginal-zone origin: is this a distinct entity?, Blood, 123, 1199, 10.1182/blood-2013-07-515155 Bruscaggin, 2014, Molecular lesions of signalling pathway genes in clonal B-cell lymphocytosis with marginal zone features., Br J Haematol, 167, 718, 10.1111/bjh.13052 Gibson, 2011, Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis., Haematologica, 96, 1144, 10.3324/haematol.2011.042333 Gradowski, 2012, Chronic lymphocytic leukemia/small lymphocytic lymphoma with cyclin D1 positive proliferation centers do not have CCND1 translocations or gains and lack SOX11 expression., Am J Clin Pathol, 138, 132, 10.1309/AJCPIVKZRMPF93ET Gibson, Proliferation centres of chronic lymphocytic leukaemia/small lymphocytic lymphoma have enhanced expression of MYC protein, which does not result from rearrangement or gain of the MYC gene [published online ahead of print November 16, 2015]., Br J Haematol Giné, 2010, Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia (“accelerated” chronic lymphocytic leukemia) with aggressive clinical behavior., Haematologica, 95, 1526, 10.3324/haematol.2010.022277 Ciccone, 2012, Proliferation centers in chronic lymphocytic leukemia: correlation with cytogenetic and clinicobiological features in consecutive patients analyzed on tissue microarrays., Leukemia, 26, 499, 10.1038/leu.2011.247 Falchi, 2014, Correlation between FDG/PET, histology, clinical characteristics, and survival in 332 patients with chronic lymphocytic leukemia., Blood, 123, 2783, 10.1182/blood-2013-11-536169 Jegalian, 2011, Follicular lymphoma in situ: clinical implications and comparisons with partial involvement by follicular lymphoma., Blood, 118, 2976, 10.1182/blood-2011-05-355255 Pillai, 2013, Follicular lymphoma-like B cells of uncertain significance (in situ follicular lymphoma) may infrequently progress, but precedes follicular lymphoma, is associated with other overt lymphomas and mimics follicular lymphoma in flow cytometric studies., Haematologica, 98, 1571, 10.3324/haematol.2013.085506 Mamessier, 2014, Early lesions of follicular lymphoma: a genetic perspective., Haematologica, 99, 481, 10.3324/haematol.2013.094474 Schmidt, 2014, Increasing genomic and epigenomic complexity in the clonal evolution from in situ to manifest t(14;18)-positive follicular lymphoma., Leukemia, 28, 1103, 10.1038/leu.2013.307 Tellier, 2014, Human t(14;18)positive germinal center B cells: a new step in follicular lymphoma pathogenesis?, Blood, 123, 3462, 10.1182/blood-2013-12-545954 Roulland, 2014, t(14;18) translocation: a predictive blood biomarker for follicular lymphoma., J Clin Oncol, 32, 1347, 10.1200/JCO.2013.52.8190 Liu, 2013, Follicular lymphomas in children and young adults: a comparison of the pediatric variant with usual follicular lymphoma., Am J Surg Pathol, 37, 333, 10.1097/PAS.0b013e31826b9b57 Louissaint, 2012, Pediatric-type nodal follicular lymphoma: an indolent clonal proliferation in children and adults with high proliferation index and no BCL2 rearrangement., Blood, 120, 2395, 10.1182/blood-2012-05-429514 Martin-Guerrero, 2013, Recurrent loss of heterozygosity in 1p36 associated with TNFRSF14 mutations in IRF4 translocation negative pediatric follicular lymphomas., Haematologica, 98, 1237, 10.3324/haematol.2012.073916 Salaverria, 2011, Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults., Blood, 118, 139, 10.1182/blood-2011-01-330795 Karube, 2007, CD10-MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features., Blood, 109, 3076, 10.1182/blood-2006-09-045989 Schmatz, 2011, Primary follicular lymphoma of the duodenum is a distinct mucosal/submucosal variant of follicular lymphoma: a retrospective study of 63 cases., J Clin Oncol, 29, 1445, 10.1200/JCO.2010.32.9193 Takata, 2013, Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics [published correction appears in Mod Pathol. 2013;26(8):1152]., Mod Pathol, 26, 22, 10.1038/modpathol.2012.127 Katzenberger, 2009, A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36., Blood, 113, 1053, 10.1182/blood-2008-07-168682 Jares, 2012, Molecular pathogenesis of mantle cell lymphoma., J Clin Invest, 122, 3416, 10.1172/JCI61272 Carvajal-Cuenca, 2012, In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior., Haematologica, 97, 270, 10.3324/haematol.2011.052621 Tiacci, 2011, BRAF mutations in hairy-cell leukemia., N Engl J Med, 364, 2305, 10.1056/NEJMoa1014209 Waterfall, 2014, High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias., Nat Genet, 46, 8, 10.1038/ng.2828 Treon, 2012, MYD88 L265P somatic mutation in Waldenström’s macroglobulinemia., N Engl J Med, 367, 826, 10.1056/NEJMoa1200710 Swerdlow, The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing., Virchows Arch Hamadeh, 2015, MYD88 L265P mutation analysis helps define nodal lymphoplasmacytic lymphoma., Mod Pathol, 28, 564, 10.1038/modpathol.2014.120 Hamadeh, 2014, Gamma heavy chain disease lacks the MYD88 L265p mutation associated with lymphoplasmacytic lymphoma., Haematologica, 99, e154, 10.3324/haematol.2014.108688 Treon, 2014, Somatic mutations in MYD88 and CXCR4 are determinants of clinical presentation and overall survival in Waldenstrom macroglobulinemia., Blood, 123, 2791, 10.1182/blood-2014-01-550905 Roccaro, 2014, C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma., Blood, 123, 4120, 10.1182/blood-2014-03-564583 Schmidt, 2015, MYD88 L265P and CXCR4 mutations in lymphoplasmacytic lymphoma identify cases with high disease activity., Br J Haematol, 169, 795, 10.1111/bjh.13361 Wang, 2011, SF3B1 and other novel cancer genes in chronic lymphocytic leukemia., N Engl J Med, 365, 2497, 10.1056/NEJMoa1109016 Puente, 2011, Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia., Nature, 475, 101, 10.1038/nature10113 Quesada, 2011, Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia., Nat Genet, 44, 47, 10.1038/ng.1032 Villamor, 2013, NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome., Leukemia, 27, 1100, 10.1038/leu.2012.357 Puente, 2015, Non-coding recurrent mutations in chronic lymphocytic leukaemia., Nature, 526, 519, 10.1038/nature14666 Queirós, 2015, A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact., Leukemia, 29, 598, 10.1038/leu.2014.252 Fabbri, 2011, Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation., J Exp Med, 208, 1389, 10.1084/jem.20110921 Jeromin, 2014, SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients., Leukemia, 28, 108, 10.1038/leu.2013.263 Rossi, 2013, Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia., Blood, 121, 1403, 10.1182/blood-2012-09-458265 Baliakas, 2015, Recurrent mutations refine prognosis in chronic lymphocytic leukemia., Leukemia, 29, 329, 10.1038/leu.2014.196 Foà, 2013, A mechanism-driven treatment for chronic lymphocytic leukemia?, N Engl J Med, 369, 85, 10.1056/NEJMe1303054 Beà, 2013, Landscape of somatic mutations and clonal evolution in mantle cell lymphoma., Proc Natl Acad Sci USA, 110, 18250, 10.1073/pnas.1314608110 Kridel, 2012, Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma., Blood, 119, 1963, 10.1182/blood-2011-11-391474 Salaverria, 2013, CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma., Blood, 121, 1394, 10.1182/blood-2012-08-452284 Green, 2015, Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation., Proc Natl Acad Sci USA, 112, E1116, 10.1073/pnas.1501199112 Okosun, 2014, Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma., Nat Genet, 46, 176, 10.1038/ng.2856 Pastore, 2015, Integration of gene mutations in risk prognostication for patients receiving first-line immunochemotherapy for follicular lymphoma: a retrospective analysis of a prospective clinical trial and validation in a population-based registry., Lancet Oncol, 16, 1111, 10.1016/S1470-2045(15)00169-2 Loeffler, 2015, Genomic and epigenomic co-evolution in follicular lymphomas., Leukemia, 29, 456, 10.1038/leu.2014.209 Bödör, 2013, EZH2 mutations are frequent and represent an early event in follicular lymphoma., Blood, 122, 3165, 10.1182/blood-2013-04-496893 Young, 2015, B-cell receptor signaling in diffuse large B-cell lymphoma., Semin Hematol, 52, 77, 10.1053/j.seminhematol.2015.01.008 Roschewski, 2014, Diffuse large B-cell lymphoma-treatment approaches in the molecular era., Nat Rev Clin Oncol, 11, 12, 10.1038/nrclinonc.2013.197 Scott, 2014, Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue., Blood, 123, 1214, 10.1182/blood-2013-11-536433 Scott, 2015, Prognostic significance of diffuse large B-cell lymphoma cell of origin determined by digital gene expression in formalin-fixed paraffin-embedded tissue biopsies., J Clin Oncol, 33, 2848, 10.1200/JCO.2014.60.2383 Masqué-Soler, 2013, Molecular classification of mature aggressive B-cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens., Blood, 122, 1985, 10.1182/blood-2013-06-508937 Mareschal, Accurate classification of germinal center B-cell-like/activated B-cell-like diffuse large B-cell lymphoma using a simple and rapid reverse transcriptase-multiplex ligation-dependent probe amplification assay: a CALYM Study., J Mol Diagn Karube, 2015, MYC alterations in diffuse large B-cell lymphomas., Semin Hematol, 52, 97, 10.1053/j.seminhematol.2015.01.009 Swerdlow, 2014, Diagnosis of ‘double hit’ diffuse large B-cell lymphoma and B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and Burkitt lymphoma: when and how, FISH versus IHC., Hematology Am Soc Hematol Educ Program, 2014, 90, 10.1182/asheducation-2014.1.90 Johnson, 2012, Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone., J Clin Oncol, 30, 3452, 10.1200/JCO.2011.41.0985 Molina, 2014, Young patients with non-germinal center B-cell-like diffuse large B-cell lymphoma benefit from intensified chemotherapy with ACVBP plus rituximab compared with CHOP plus rituximab: analysis of data from the Groupe d’Etudes des Lymphomes de l’Adulte/Lymphoma Study Association phase III trial LNH 03-2B., J Clin Oncol, 32, 3996, 10.1200/JCO.2013.54.9493 Pasqualucci, 2015, The genetic landscape of diffuse large B-cell lymphoma., Semin Hematol, 52, 67, 10.1053/j.seminhematol.2015.01.005 Intlekofer, 2014, Precision therapy for lymphoma--current state and future directions., Nat Rev Clin Oncol, 11, 585, 10.1038/nrclinonc.2014.137 Dojcinov, 2011, Age-related EBV-associated lymphoproliferative disorders in the Western population: a spectrum of reactive lymphoid hyperplasia and lymphoma., Blood, 117, 4726, 10.1182/blood-2010-12-323238 Nicolae, 2015, EBV-positive large B-cell lymphomas in young patients: a nodal lymphoma with evidence for a tolerogenic immune environment., Blood, 126, 863, 10.1182/blood-2015-02-630632 Said, 2015, The expanding spectrum of EBV+ lymphomas., Blood, 126, 827, 10.1182/blood-2015-06-648097 Dojcinov, 2010, EBV positive mucocutaneous ulcer--a study of 26 cases associated with various sources of immunosuppression., Am J Surg Pathol, 34, 405, 10.1097/PAS.0b013e3181cf8622 Hart, 2014, EBV-positive mucocutaneous ulcer in organ transplant recipients: a localized indolent posttransplant lymphoproliferative disorder., Am J Surg Pathol, 38, 1522, 10.1097/PAS.0000000000000282 Love, 2012, The genetic landscape of mutations in Burkitt lymphoma., Nat Genet, 44, 1321, 10.1038/ng.2468 Richter, 2012, Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing., Nat Genet, 44, 1316, 10.1038/ng.2469 Schmitz, 2012, Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics., Nature, 490, 116, 10.1038/nature11378 Sander, 2012, Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis., Cancer Cell, 22, 167, 10.1016/j.ccr.2012.06.012 Salaverria, 2014, A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma., Blood, 123, 1187, 10.1182/blood-2013-06-507996 Ferreiro, 2015, Post-transplant molecularly defined Burkitt lymphomas are frequently MYC-negative and characterized by the 11q-gain/loss pattern., Haematologica, 100, e275, 10.3324/haematol.2015.124305 Dave, 2006, Molecular diagnosis of Burkitt’s lymphoma., N Engl J Med, 354, 2431, 10.1056/NEJMoa055759 Hummel, 2006, A biologic definition of Burkitt’s lymphoma from transcriptional and genomic profiling., N Engl J Med, 354, 2419, 10.1056/NEJMoa055351 Campo, 2015, MYC in DLBCL: partners matter., Blood, 126, 2439, 10.1182/blood-2015-10-671362 Momose, 2015, The diagnostic gray zone between Burkitt lymphoma and diffuse large B-cell lymphoma is also a gray zone of the mutational spectrum., Leukemia, 29, 1789, 10.1038/leu.2015.34 Gebauer, 2013, ID3 mutations are recurrent events in double-hit B-cell lymphomas., Anticancer Res, 33, 4771 Kluin, High grade B-cell lymphoma. Lemonnier, 2012, Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters., Blood, 120, 1466, 10.1182/blood-2012-02-408542 Sakata-Yanagimoto, 2014, Somatic RHOA mutation in angioimmunoblastic T cell lymphoma., Nat Genet, 46, 171, 10.1038/ng.2872 Cairns, 2012, IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma., Blood, 119, 1901, 10.1182/blood-2011-11-391748 Nicolae, 2013, Peripheral T-cell lymphomas of follicular T-helper cell derivation with Hodgkin/Reed-Sternberg cells of B-cell lineage: both EBV-positive and EBV-negative variants exist., Am J Surg Pathol, 37, 816, 10.1097/PAS.0b013e3182785610 Moroch, 2012, Follicular peripheral T-cell lymphoma expands the spectrum of classical Hodgkin lymphoma mimics., Am J Surg Pathol, 36, 1636, 10.1097/PAS.0b013e318268d9ff Balagué, 2007, Epstein-Barr virus negative clonal plasma cell proliferations and lymphomas in peripheral T-cell lymphomas: a phenomenon with distinctive clinicopathologic features., Am J Surg Pathol, 31, 1310, 10.1097/PAS.0b013e3180339f18 Iqbal, 2014, Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma., Blood, 123, 2915, 10.1182/blood-2013-11-536359 Wang, 2014, GATA-3 expression identifies a high-risk subset of PTCL, NOS with distinct molecular and clinical features., Blood, 123, 3007, 10.1182/blood-2013-12-544809 Palomero, 2014, Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas., Nat Genet, 46, 166, 10.1038/ng.2873 Agnelli, 2012, Identification of a 3-gene model as a powerful diagnostic tool for the recognition of ALK-negative anaplastic large-cell lymphoma., Blood, 120, 1274, 10.1182/blood-2012-01-405555 Piccaluga, 2013, Molecular profiling improves classification and prognostication of nodal peripheral T-cell lymphomas: results of a phase III diagnostic accuracy study., J Clin Oncol, 31, 3019, 10.1200/JCO.2012.42.5611 Attygalle, 2014, Peripheral T-cell and NK-cell lymphomas and their mimics; taking a step forward - report on the Lymphoma Workshop of the XVIth meeting of the European Association for Haematopathology and the Society for Hematopathology., Histopathology, 64, 171, 10.1111/his.12251 Crescenzo, 2015, Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma [published correction appears in Cancer Cell. 2015;27(5):744]., Cancer Cell, 27, 516, 10.1016/j.ccell.2015.03.006 Parilla Castellar, 2014, ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes., Blood, 124, 1473, 10.1182/blood-2014-04-571091 King, 2016, Morphologic features of ALK-negative anaplastic large cell lymphomas with DUSP22 rearrangements., Am J Surg Pathol, 40, 36, 10.1097/PAS.0000000000000500 Parrilla Castellar, 2014, ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes., Blood, 124, 1473, 10.1182/blood-2014-04-571091 Feldman, 2011, Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing., Blood, 117, 915, 10.1182/blood-2010-08-303305 Karai, 2013, Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis., Am J Surg Pathol, 37, 1173, 10.1097/PAS.0b013e318282d01e Saggini, 2010, A variant of lymphomatoid papulosis simulating primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma. Description of 9 cases., Am J Surg Pathol, 34, 1168, 10.1097/PAS.0b013e3181e75356 Kempf, 2013, Angioinvasive lymphomatoid papulosis: a new variant simulating aggressive lymphomas., Am J Surg Pathol, 37, 1, 10.1097/PAS.0b013e3182648596 Thompson, 2010, Effusion-associated anaplastic large cell lymphoma of the breast: time for it to be defined as a distinct clinico-pathological entity., Haematologica, 95, 1977, 10.3324/haematol.2010.026237 Keech, 1997, Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant., Plast Reconstr Surg, 100, 554, 10.1097/00006534-199708000-00065 Miranda, 2014, Breast implant-associated anaplastic large-cell lymphoma: long-term follow-up of 60 patients., J Clin Oncol, 32, 114, 10.1200/JCO.2013.52.7911 Clemens, 2016, Complete surgical excision is essential for the management of patients with breast implant-associated anaplastic large-cell lymphoma., J Clin Oncol, 34, 160, 10.1200/JCO.2015.63.3412 Laurent, 2016, Breast implant associated anaplastic large cell lymphoma: two distinct clinicopathological variants with different outcomes., Ann Oncol, 27, 306, 10.1093/annonc/mdv575 Swerdlow, 2014, Cytotoxic T-cell and NK-cell lymphomas: current questions and controversies., Am J Surg Pathol, 38, e60, 10.1097/PAS.0000000000000295 Perry, 2013, Indolent T-cell lymphoproliferative disease of the gastrointestinal tract., Blood, 122, 3599, 10.1182/blood-2013-07-512830 Petrella, 2007, Indolent CD8-positive lymphoid proliferation of the ear: a distinct primary cutaneous T-cell lymphoma?, Am J Surg Pathol, 31, 1887, 10.1097/PAS.0b013e318068b527 Macon, 2001, Hepatosplenic alphabeta T-cell lymphomas: a report of 14 cases and comparison with hepatosplenic gammadelta T-cell lymphomas., Am J Surg Pathol, 25, 285, 10.1097/00000478-200103000-00002 Toro, 2003, Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma., Blood, 101, 3407, 10.1182/blood-2002-05-1597 Guitart, 2012, Cutaneous γδ T-cell lymphomas: a spectrum of presentations with overlap with other cytotoxic lymphomas., Am J Surg Pathol, 36, 1656, 10.1097/PAS.0b013e31826a5038 Rodríguez-Pinilla, 2013, TCR-γ expression in primary cutaneous T-cell lymphomas., Am J Surg Pathol, 37, 375, 10.1097/PAS.0b013e318275d1a2 Endly, 2013, Indolent course of cutaneous gamma-delta T-cell lymphoma., J Cutan Pathol, 40, 896 Koskela, 2012, Somatic STAT3 mutations in large granular lymphocytic leukemia., N Engl J Med, 366, 1905, 10.1056/NEJMoa1114885 Jerez, 2012, STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia., Blood, 120, 3048, 10.1182/blood-2012-06-435297 Bergmann, 2014, Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia., Genes Chromosomes Cancer, 53, 309, 10.1002/gcc.22141 Kiel, 2014, Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia., Blood, 124, 1460, 10.1182/blood-2014-03-559542 Rajala, 2013, Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia., Blood, 121, 4541, 10.1182/blood-2012-12-474577 Nicolae, 2014, Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas., Leukemia, 28, 2244, 10.1038/leu.2014.200 Küçük, 2015, Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells., Nat Commun, 6, 6025, 10.1038/ncomms7025 Deleeuw, 2007, Whole-genome analysis and HLA genotyping of enteropathy-type T-cell lymphoma reveals 2 distinct lymphoma subtypes., Gastroenterology, 132, 1902, 10.1053/j.gastro.2007.03.036 Tan, 2011, Nuclear expression of MATK is a novel marker of type II enteropathy-associated T-cell lymphoma., Leukemia, 25, 555, 10.1038/leu.2010.295 Tomita, 2015, Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan., Mod Pathol, 28, 1286, 10.1038/modpathol.2015.85 Chan, 2011, Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent γδ T-cell receptor expression., Am J Surg Pathol, 35, 1557, 10.1097/PAS.0b013e318222dfcd Rodríguez Pinilla, 2009, Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma expresses follicular T-cell markers., Am J Surg Pathol, 33, 81, 10.1097/PAS.0b013e31818e52fe Garcia-Herrera, 2008, Primary cutaneous small/medium CD4+ T-cell lymphomas: a heterogeneous group of tumors with different clinicopathologic features and outcome., J Clin Oncol, 26, 3364, 10.1200/JCO.2008.16.1307 Grogg, 2008, Primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma: a clonal T-cell lymphoproliferative disorder with indolent behavior., Mod Pathol, 21, 708, 10.1038/modpathol.2008.40 Beltraminelli, 2009, Primary cutaneous CD4+ small-/medium-sized pleomorphic T-cell lymphoma: a cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance? 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