Tissue-based map of the human proteome

American Association for the Advancement of Science (AAAS) - Tập 347 Số 6220 - 2015
Mathias Uhlén1,2,3, Linn Fagerberg3, Björn M. Hallström1,3, Cecilia Lindskog4, Per Oksvold3, Adil Mardinoğlu5, Åsa Sivertsson3, Caroline Kampf4, Evelina Sjöstedt4,3, Anna Asplund4, Ing‐Marie Olsson4, Karolina Edlund6, Emma Lundberg3, Sanjay Navani7, Cristina Al‐Khalili Szigyarto1, Jacob Odeberg3, Dijana Djureinovic4, Jenny Ottosson Takanen1, Sophia Hober1, Tove Alm3, Per-Henrik Edqvist4, Holger Berling1, Hanna Tegel1, Jan Mulder8, Johan Rockberg1, Peter Nilsson3, Jochen M. Schwenk3, Marica Hamsten1, Kalle von Feilitzen3, Maud Forsberg3, Lukas Persson3, Fredric Johansson3, Martin Zwahlen3, Gunnar von Heijne9, Jens Nielsen5, Fredrik Pontén4
1Department of Proteomics, KTH—Royal Institute of Technology, SE-106 91 Stockholm, Sweden.
2Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, DK-2970 Hørsholm, Denmark
3Science for Life Laboratory, KTH—Royal Institute of Technology, SE-171 21 Stockholm, Sweden.
4Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden·
5Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden
6Leibniz Research Centre for Working Environment and Human Factors (IfADo) at Dortmund TU, D-44139 Dortmund, Germany.
7Lab Surgpath, Mumbai, India
8Science for Life Laboratory, Department of Neuroscience, Karolinska Institute, SE-171 77 Stockholm, Sweden
9Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden

Tóm tắt

Protein expression across human tissues Sequencing the human genome gave new insights into human biology and disease. However, the ultimate goal is to understand the dynamic expression of each of the approximately 20,000 protein-coding genes and the function of each protein. Uhlén et al. now present a map of protein expression across 32 human tissues. They not only measured expression at an RNA level, but also used antibody profiling to precisely localize the corresponding proteins. An interactive website allows exploration of expression patterns across the human body. Science , this issue 10.1126/science.1260419

Từ khóa


Tài liệu tham khảo

10.1093/nar/gks1236

10.1093/nar/gkr1079

10.1093/nar/gkq1112

10.1093/nar/gkg091

10.1093/database/bar009

10.1021/pr300830v

10.1038/nature11247

10.1038/nbt.2152

10.1038/nature13319

10.1038/nature13302

10.1038/nrm2067

10.1093/hmg/ddu309

10.1038/msb.2008.61

10.1038/nbt1210-1248

10.1074/mcp.M113.035600

10.1096/fj.14-250555

10.1093/molehr/gau018

10.1007/s00535-014-0958-7

10.1093/nar/gkt1068

COSMIC catalogue of somatic mutations in cancer (2014); http://cancer.sanger.ac.uk/cancergenome/projects/census.

10.1038/msb.2010.106

10.1126/science.1188308

10.1038/nmeth.1701

10.1093/nar/gkm256

10.1093/bioinformatics/btn550

10.1371/journal.pcbi.1000598

10.1093/nar/gks1123

10.1038/srep02650

10.1038/nature11252

10.1038/nature11125

10.1021/pr3009308

10.1053/joca.2001.0482

10.1038/nature05874

10.1186/gb-2013-14-7-r70

10.1111/j.1365-2796.2011.02493.x

10.1038/ncomms4083

10.1002/msb.145122

Human Metabolic Atlas (2014); www.metabolicatlas.org/.

10.1016/j.tibtech.2012.02.002

10.1038/nature04209

Kampf C., Olsson I., Ryberg U., Sjöstedt E., Pontén F., Production of tissue microarrays, immunohistochemistry staining and digitalization within the human protein atlas. J. Vis. Exp. 2012, 3620 (2012).22688270

10.1093/bioinformatics/btp120

10.1038/nbt.1621

10.1093/nar/gkt1196

Database for Annotation Visualization and Integrated Discovery (DAVID) Bioinformatics Resources v6.7 (2014); http://david.abcc.ncifcrf.gov/.

10.1002/pmic.200900258

10.1093/bioinformatics/btl677

10.1186/1471-2105-10-159

10.1016/j.jmb.2004.03.016

10.1073/pnas.0711151105

E. L. Sonnhammer G. von Heijne A. Krogh A hidden Markov model for predicting transmembrane helices in protein sequences in Proceedings of the Sixth International Conference on Intelligent Systems for Molecular Biology J. Glasgow Ed. Montréal Québec 28 June to 1 July 1998 (AAAI Press Menlo Park CA 1998).

10.1110/ps.0305103

10.1016/j.jmb.2004.05.028

10.1016/j.copbio.2010.06.004

10.1093/nar/gkh048

10.1182/blood-2005-03-1338

10.1093/nar/gkt1140

Thông tin
Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 347 Số 6220

Thông tin tác giả