G Protein Activation of a Hormone-Stimulated Phosphatase in Human Tumor Cells

American Association for the Advancement of Science (AAAS) - Tập 256 Số 5060 - Trang 1215-1217 - 1992
Ming Gui Pan1,2, Tullio Florio2, Philip A. Stork1,2
1Department of Cell Biology and Anatomy, Oregon Health Sciences University, L474, 3181 SW Sam Jackson Park Road, Portland, OR 97201
2The Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, L474, 3181 SW Sam Jackson Park Road, Portland, OR 97201.

Tóm tắt

The growth-inhibiting peptide hormone somatostatin stimulates phosphotyrosine phosphatase activity in the human pancreatic cell line MIA PaCa-2. This hormonal activation was mediated by a pertussis toxin-sensitive guanosine 5′-triphosphate-binding protein (G protein) in the membranes of these cells. Activation of this G protein by somatostatin stimulated the dephosphorylation of exogenous epidermal growth factor receptor prepared from A-431 cells in vitro. This pathway may mediate the antineoplastic action of somatostatin in these cells and in human tumors and could represent a general mechanism of G protein coupling that is utilized by normal cells in the hormonal control of cell growth.

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