Chimpanzee Reservoirs of Pandemic and Nonpandemic HIV-1
Tóm tắt
Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus (SIV) thus far identified only in captive members of the chimpanzee subspecies
Từ khóa
Tài liệu tham khảo
C. P. Groves, in Mammalian Species of the World: A Taxonomic and Geographic Reference, D. E. Wilson, D. M. Reader, Eds. (Smithsonian Institution Press, Washington, DC, ed. 2, 1993), pp. 243–277.
Materials and methods are available as supporting material on Science Online.
In contrast to plasma samples from uninfected humans which exhibit false positive Western blot reactivity to HIV-1 p24 in as many as 10 to 15% of individuals (www.fda.gov/cber/products/hiv1cam052898.htm) we have found no such nonspecific cross-reactivity of chimpanzee immunoglobulin extracted by the RNA later method from over 2000 fecal specimens.
F. Van Heuverswyn et al . 13th Conference on Retroviruses and Opportunistic Infections Abstract 132 available at www.retroconference.org/2006/Abstracts/26513.htm (2006).
We thank the Cameroonian Ministries of Health Environment and Forestry and Research for permission to perform this study; J. Dupain C. Neel and M. Epanda (Projet Grands Singes); L. Usongo D. Dontego F. Espedi and B. Tshikangwa (World Wildlife Fund); and G. Etoga and D. M'bohand (Ministry of Environment and Forestry) for assistance in the field. This work was supported in part by the NIH (grants R01 AI50529 R01 AI58715 and P30 AI 27767) the Bristol Myers Freedom to Discover Program the Institut de Recherche pour le Développement and the Howard Hughes Medical Institute. New SIVcpz Ptt sequences are available at GenBank under accession numbers DQ370366-DQ370419 and DQ373063-DQ373066; chimpanzee mtDNA sequences are available under DQ367532-DQ367613 and DQ370307-DQ370365.