The complement factor H‐related proteins

Immunological Reviews - Tập 274 Số 1 - Trang 191-201 - 2016
Nicholas R. Medjeral-Thomas1, Matthew C. Pickering1
1Centre for Complement and Inflammation Research, Imperial College, London, UK

Tóm tắt

SummaryThe role of the complement factor H‐related (FHR) proteins in homeostasis, pathogen defense, and autoimmune disease has recently attracted considerable interest. We highlight the exciting research that has contributed to our understanding of the FHR protein family. Unlike factor H, a potent negative regulator of complement C3 activation, the FHR proteins appear to promote C3 activation. These data have important implications for understanding complement‐mediated diseases because, depending on the context, the balance between the actions of factor H and the FHR proteins determines the degree of complement activation.

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Tài liệu tham khảo

10.4049/jimmunol.166.11.6820

10.2215/CJN.06230614

10.1038/ni.1923

10.1016/j.it.2004.04.008

10.1074/jbc.M401318200

10.4049/jimmunol.0901141

10.1016/j.molimm.2007.11.003

10.1084/jem.154.3.856

10.1042/bj3020429

10.1016/j.imbio.2012.07.021

10.1084/jem.142.4.856

10.4049/jimmunol.179.4.2600

10.1111/1523-1747.ep12275445

10.1172/JCI112372

10.1016/j.molimm.2004.02.005

10.1084/jem.146.1.257

10.1073/pnas.73.9.3268

10.1021/bi4003452

10.1002/eji.1830171015

10.1042/bj2580927

10.1016/S0167-5699(98)01432-7

10.1084/jem.164.4.1274

10.1007/s002510050534

10.1086/318201

10.1371/journal.pone.0060352

10.1016/j.vaccine.2008.11.021

10.1111/j.1365-2249.2006.03071.x

10.1172/JCI16651

10.1016/j.it.2008.04.008

10.1182/blood-2009-02-205641

Timmann C, 1991, Two major serum components antigenically related to complement factor H are different glycosylation forms of a single protein with no factor H‐like complement regulatory functions, J Immunol, 146, 1265, 10.4049/jimmunol.146.4.1265

Skerka C, 1992, Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H‐related genes, J Immunol, 148, 3313, 10.4049/jimmunol.148.10.3313

Skerka C, 1991, Molecular cloning of a human serum protein structurally related to complement factor H, J Biol Chem, 266, 12015, 10.1016/S0021-9258(18)99058-7

10.1182/blood-2009-05-223834

10.1074/jbc.271.30.18054

10.1016/j.molimm.2013.06.001

10.1073/pnas.1219260110

10.1172/JCI68280

10.1093/ndt/gfs430

10.1016/j.it.2015.04.008

10.1093/hmg/ddq399

10.1074/jbc.272.9.5627

10.1038/sj.ejhg.5201324

10.4049/jimmunol.174.10.6250

10.1053/ajkd.2002.29873

10.1016/0167-5699(94)90155-4

10.1371/journal.pone.0078617

10.1016/S0014-5793(99)01554-9

10.1074/jbc.M007495200

10.1016/j.molimm.2009.12.005

10.1074/jbc.M112.364471

10.4049/jimmunol.1403121

10.1016/j.molimm.2008.10.029

10.1016/S0140-6736(10)60670-8

10.1038/ki.2013.348

10.1681/ASN.2012020166

10.1172/JCI71866

10.4049/jimmunol.0901702

10.1038/nature07769

10.7554/eLife.04008

10.1073/pnas.85.5.1657

10.1086/518509

10.1128/IAI.74.5.2659-2666.2006

10.4049/jimmunol.179.5.2979

10.1074/jbc.M707280200

10.1182/blood-2005-10-007252

10.1002/humu.9408

10.1007/s00467-013-2591-8

10.1016/j.molimm.2004.01.003

10.1681/ASN.2013121339

10.1182/blood-2009-05-221549

10.1182/blood-2007-02-071472

10.1182/blood-2013-05-501445

10.1371/journal.pgen.1002079

10.1126/science.1110189

10.1038/ng1890

10.1093/ndt/gfu317

10.1038/ki.2015.252

10.1038/ki.1987.72

10.1038/ng.787

10.1371/journal.pgen.1002765

10.1681/ASN.2014010096

10.1038/nri2620