Involvement of the brain type of ryanodine receptor in T‐cell proliferation

FEBS Letters - Tập 352 Số 2 - Trang 206-210 - 1994
Yoji Hakamata1, Seiichiro Nishimura1, Junichi Nakai2, Yasuyo Nakashima1, Toru Kita1, Keiji Imoto2
1Department of Geriatric Medicine, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606-01, Japan
2Department of Medical Chemistry, Kyoto University Faculty of Medicine, Sakyo-ku, Kyoto 606-01, Japan

Tóm tắt

Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T‐lymphocyte cells. Fura‐2 measurements revealed that the RYR in T‐cells functions as a ryanodine‐sensitive, caffeine‐insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T‐cells when added together with FK506.

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FEBS Letters

Tập 352 Số 2

206-210

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