Relationship between lamotrigine oral dose, serum level and its inhibitory effect on CNS: insights from transcranial magnetic stimulation

Epilepsy Research - Tập 56 - Trang 67-77 - 2003
Frithjof Tergau1, Stephan Wischer1, Hardyal S Somal2, Michael A Nitsche1, A Joe Mercer2, Walter Paulus1, Bernhard J Steinhoff1,3
1Department of Clinical Neurophysiology, University of Göttingen, Robert-Koch-Straße 40, D-37075 Göttingen, Germany
2Glaxo Wellcome Research & Development, Medical Department, Greenford, Middlesex, UK
3Epilepsiezentrum Kork, Kehl-Kork, Germany

Tài liệu tham khảo

Benetello, 2002, Therapeutic drug monitoring of lamotrigine in patients suffering from resistant partial seizures, Eur. Neurol., 48, 200, 10.1159/000066165 Brasil-Neto, 1992, Optimal focal transcranial magnetic activation of the human motor cortex: effects of coil orientation, shape of the induced current pulse, and stimulus intensity, J. Clin. Neurophysiol., 9, 132, 10.1097/00004691-199201000-00014 Catterall, 1977, Activation of the action potential Na+ ionophore by neurotoxins. An allosteric model, J. Biol. Chem., 252, 8669, 10.1016/S0021-9258(19)75273-9 Chen, 1997, Effects of phenytoin on cortical excitability in humans, Neurology, 49, 881, 10.1212/WNL.49.3.881 Cheung, 1992, An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels, Epilepsy Res., 13, 107, 10.1016/0920-1211(92)90065-2 Cohen, 1987, Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans, Clin. Pharmacol. Ther., 42, 535, 10.1038/clpt.1987.193 Della Paschoa, 2000, Pharmacokinetic–pharmacodynamic correlation of lamotrigine, flunarizine, loreclezole, CGP40116 and CGP39551 in the cortical stimulation model, Epilepsy Res., 40, 41, 10.1016/S0920-1211(00)00102-9 Di Lazzaro, 2003, Ketamine increases human motor cortex excitability to transcranial magnetic stimulation, J. Physiol., 547, 485, 10.1113/jphysiol.2002.030486 Fitton, 1995, Lamotrigine. An update of its pharmacology and therapeutic use in epilepsy, Drugs, 50, 691, 10.2165/00003495-199550040-00008 Goa, 1993, Lamotrigine. A review of its pharmacological properties and clinical efficacy in epilepsy, Drugs, 46, 152, 10.2165/00003495-199346010-00009 Jawad, 1987, Lamotrigine: single-dose pharmacokinetics and initial 1 week experience in refractory epilepsy, Epilepsy Res., 1, 194, 10.1016/0920-1211(87)90041-6 Kilpatrick, 1996, Concentration—effect and concentration—toxicity relations with lamotrigine: a prospective study, Epilepsia, 37, 534, 10.1111/j.1528-1157.1996.tb00605.x Leach, 1986, Pharmacological studies on lamotrigine, a novel potential antiepileptic drug. II. Neurochemical studies on the mechanism of action, Epilepsia, 27, 490, 10.1111/j.1528-1157.1986.tb03573.x Lees, 1993, Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neurological cultures from rat cortex, Brain Res., 612, 190, 10.1016/0006-8993(93)91660-K Löscher, 2002, New horizons in the development of antiepileptic drugs, Epilepsy Res., 50, 3, 10.1016/S0920-1211(02)00063-3 Manganotti, 1999, Cortical excitability in patients after loading doses of lamotrigine: a study with magnetic brain stimulation, Epilepsia, 40, 316, 10.1111/j.1528-1157.1999.tb00711.x Mavroudakis, 1994, Effects of diphenylhydantoin on motor potentials evoked with magnetic stimulation, Electroencephalogr. Clin. Neurophysiol., 93, 428, 10.1016/0168-5597(94)90149-X Meyer, 1999, Lamotrigine concentrations in human serum, brain tissue, and tumor tissue, Epilepsia, 40, 68, 10.1111/j.1528-1157.1999.tb01990.x Nakamura, 1996, Direct and indirect activation of human corticospinal neurons by transcranial magnetic and electrical stimulation, Neurosci. Lett., 210, 45, 10.1016/0304-3940(96)12659-8 Potschka, 2002, P-glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood–brain barrier: evidence from microdialysis experiments in rats, Neurosci. Lett., 327, 173, 10.1016/S0304-3940(02)00423-8 Ramsay, 1991, Pharmacokinetics and safety of lamotrigine (Lamictal) in patients with epilepsy, Epilepsy Res., 10, 191, 10.1016/0920-1211(91)90012-5 Strichartz, 1987, An integrated view of the molecular toxicology of sodium channel gating in excitable cells, Annu. Rev. Neurosci., 10, 237, 10.1146/annurev.ne.10.030187.001321 Tomson, 2000, Therapeutic monitoring of the new antiepileptic drugs, Eur. J. Clin. Pharmacol., 55, 697, 10.1007/s002280050001 Willow, 1982, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine, Mol. Pharmacol., 22, 627 Xiong, 1997, Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus, Epilepsy Res., 27, 187, 10.1016/S0920-1211(97)00022-3 Ziemann, 1996, Effects of antiepileptic drugs on motor cortex excitability in humans: a transcranial magnetic stimulation study, Ann. Neurol., 40, 367, 10.1002/ana.410400306 Ziemann, 1998, Transcranial magnetic stimulation: its current role in epilepsy research, Epilepsy Res., 30, 11, 10.1016/S0920-1211(97)00079-X