Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety

The American Journal of Clinical Nutrition - Tập 69 - Trang 842-856 - 1999
Reinhold Vieth1
1From the Department of Laboratory Medicine and Pathobiology, University of Toronto, and Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto.

Tài liệu tham khảo

Heaney, 1991, Calcium and vitamin D in human nutrition, 9 Takeuchi, 1995, Effects of dietary vitamin D intake on plasma levels of parathyroid hormone and vitamin D metabolites in healthy Japanese, Miner Electrolyte Metab, 21, 217 1989 Park, 1940, The therapy of rickets, JAMA, 115, 370, 10.1001/jama.1940.72810310011009a Blumberg, 1963, The prophylactic requirement and the toxicity of vitamin D, Pediatrics, 31, 512 Smith, 1969, Vitamin D requirements in adults. Clinical and metabolic studies on seven patients with nutritional osteomalacia, Bibl Nutr Dieta, 13, 44 Parfitt, 1982, Vitamin D and bone health in the elderly, Am J Clin Nutr, 36, 1014, 10.1093/ajcn/36.5.1014 Utiger, 1998, The need for more vitamin D, N Engl J Med, 338, 828, 10.1056/NEJM199803193381209 Thomas, 1998, Hypovitaminosis D in medical inpatients, N Engl J Med, 338, 777, 10.1056/NEJM199803193381201 Gallagher, 1998, Calciotropic hormones and bone markers in the elderly, J Bone Miner Res, 13, 475, 10.1359/jbmr.1998.13.3.475 Rao, 1983, Histologic evolution of vitamin D–depletion in patients with intestinal malabsorption or dietary deficiency, 224 Dawson-Hughes, 1997, Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older, N Engl J Med, 337, 670, 10.1056/NEJM199709043371003 Trang, 1998, Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2, Am J Clin Nutr, 68, 854, 10.1093/ajcn/68.4.854 Dawson-Hughes, 1997, Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women, Am J Clin Nutr, 65, 67, 10.1093/ajcn/65.1.67 Kinyamu, 1998, Dietary calcium and vitamin D intake in elderly women: effect on serum parathyroid hormone and vitamin D metabolites, Am J Clin Nutr, 67, 342, 10.1093/ajcn/67.2.342 Adams, 1997, Gains in bone mineral density with resolution of vitamin D intoxication, Ann Intern Med, 127, 203, 10.7326/0003-4819-127-3-199708010-00004 Marriott, 1997, Vitamin D supplementation: a word of caution, Ann Intern Med, 127, 231, 10.7326/0003-4819-127-3-199708010-00009 Dawson-Hughes, 1996, Calcium and vitamin D nutritional needs of elderly women, J Nutr, 126, 1165S, 10.1093/jn/126.suppl_4.1165S 1997, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes Gloth, 1991, Is the recommended daily allowance for vitamin D too low for the homebound elderly?, J Am Geriatr Soc, 39, 137, 10.1111/j.1532-5415.1991.tb01615.x Hathcock, 1997, Vitamins and minerals: efficacy and safety, Am J Clin Nutr, 66, 427, 10.1093/ajcn/66.2.427 Jongen, 1984, An international comparison of vitamin D metabolite measurements, Clin Chem, 30, 399, 10.1093/clinchem/30.3.399 Haddock, 1982, 25(OH)D serum levels in the normal Puerto Rican population and in subjects with tropical sprue and parathyroid disease, Puerto Rico Health Sci J, 1, 85 Haddad, 1971, Competitive protein-binding radioassay for 25-hydroxycholecalciferol, J Clin Endocrinol, 33, 992, 10.1210/jcem-33-6-992 Better, 1980, Increased incidence of nephrolithiasis in lifeguards in Israel, 467 Chapuy, 1992, Vitamin D3 and calcium to prevent hip fractures in the elderly woman, N Engl J Med, 327, 1637, 10.1056/NEJM199212033272305 Snell, 1978, Ultra-violet irradiation and 25-hydroxy-vitamin D levels in sick old people, Age Ageing, 7, 225, 10.1093/ageing/7.4.225 Davie, 1982, Vitamin D from skin: contribution to vitamin D status compared with oral vitamin D in normal and anticonvulsant-treated subjects, Clin Sci, 63, 461, 10.1042/cs0630461 Davies, 1997, The effects of simulated solar exposure upon serum vitamin D3 and 25-hydroxyvitamin D3 in healthy controls and patients with metabolic bone disease, 711 Chel, 1998, Ultraviolet irradiation corrects vitamin D deficiency and suppresses secondary hyperparathyroidism in the elderly, J Bone Miner Res, 13, 1238, 10.1359/jbmr.1998.13.8.1238 Reid, 1986, The acute biochemical effects of four proprietary calcium preparations, Aust N Z J Med, 16, 193, 10.1111/j.1445-5994.1986.tb01147.x Falkenbach, 1992, Primary prevention of osteopenia, Schweiz Med Wochenschr, 122, 1728 Matsuoka, 1990, Suntanning and cutaneous synthesis of vitamin D3, J Lab Clin Med, 116, 87 Mawer, 1984, Ultraviolet irradiation increases serum 1,25-dihydroxyvitamin D in vitamin-D-replete adults, Miner Electrolyte Metab, 10, 117 Stamp, 1977, Comparison of oral 25-hydroxycholecalciferol, vitamin D, and ultraviolet light as determinants of circulating 25-hydroxyvitamin D, Lancet, 1, 1341, 10.1016/S0140-6736(77)92553-3 Dent, 1973, Effect of chapattis and ultraviolet irradiation on nutritional rickets in an Indian immigrant, Lancet, 1, 1282, 10.1016/S0140-6736(73)91296-8 Varghese, 1989, The effect of ultraviolet B radiation treatments on calcium excretion and vitamin D metabolites in kidney stone formers, Clin Nephrol, 31, 225 Krause, 1998, Ultraviolet B and blood pressure, Lancet, 352, 709, 10.1016/S0140-6736(05)60827-6 Stamp, 1975, Factors in human vitamin D nutrition and in the production and cure of classical rickets, Proc Nutr Soc, 34, 119, 10.1079/PNS19750022 Holick, 1995, Environmental factors that influence the cutaneous production of vitamin D, Am J Clin Nutr, 61, 638S, 10.1093/ajcn/61.3.638S Holick, 1995, Noncalcemic actions of 1,25-dihydroxyvitamin D3 and clinical applications, Bone, 17, 107S, 10.1016/8756-3282(95)00195-J Lo, 1986, Indian and Pakistani immigrants have the same capacity as Caucasians to produce vitamin D in response to ultraviolet irradiation, Am J Clin Nutr, 44, 683, 10.1093/ajcn/44.5.683 Need, 1993, Effects of skin thickness, age, body fat, and sunlight on serum 25-hydroxyvitamin D, Am J Clin Nutr, 58, 882, 10.1093/ajcn/58.6.882 MacLaughlin, 1985, Aging decreases the capacity of human skin to produce vitamin D3, J Clin Invest, 76, 1536, 10.1172/JCI112134 Preece, 1975, Studies of vitamin D deficiency in man, Q J Med, 44, 575 Dlugos, 1995, Effects of the submarine environment on renal-stone risk factors and vitamin D metabolism, Undersea Hyperb Med, 22, 145 Ooms, 1995, Prevention of bone loss by vitamin D supplementation in elderly women: a randomized double-blind trial, J Clin Endocrinol Metab, 80, 1052 Lips, 1996, Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial, Ann Intern Med, 124, 400, 10.7326/0003-4819-124-4-199602150-00003 McAuley, 1997, Low vitamin D status is common among elderly Dunedin women, N Z Med J, 110, 275 Graafmans, 1997, The effect of vitamin D supplementation on the bone mineral density of the femoral neck is associated with vitamin D receptor genotype, J Bone Miner Res, 12, 1241, 10.1359/jbmr.1997.12.8.1241 Dawson-Hughes, 1991, Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women, Ann Intern Med, 115, 505, 10.7326/0003-4819-115-7-505 O'Dowd, 1993, Exogenous calciferol (vitamin D) and vitamin D endocrine status among elderly nursing home residents in the New York City area, J Am Geriatr Soc, 41, 414, 10.1111/j.1532-5415.1993.tb06950.x Dawson-Hughes, 1995, Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D, Am J Clin Nutr, 61, 1140, 10.1093/ajcn/61.5.1140 Sebert, 1995, Evaluation of a new solid formulation of calcium and vitamin D in institutionalized elderly subjects. A randomized comparative trial versus separate administration of both constituents, Rev Rhum Engl Ed, 62, 288 Van Der Klis, 1996, Changes in vitamin-D metabolites and parathyroid hormone in plasma following cholecalciferol administration to pre- and postmenopausal women in the Netherlands in early spring and to postmenopausal women in Curacao, Br J Nutr, 75, 637, 10.1079/BJN19960166 Lips, 1988, The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects, J Clin Endocrinol Metab, 67, 644, 10.1210/jcem-67-4-644 Chapuy, 1996, Biochemical effects of calcium and vitamin D supplementation in elderly, institutionalized, vitamin D-deficient patients, Rev Rhum Engl Ed, 63, 135 Freaney, 1993, Secondary hyperparathyroidism in elderly people: combined effect of renal insufficiency and vitamin D deficiency, Am J Clin Nutr, 58, 187, 10.1093/ajcn/58.2.187 McKenna, 1985, Hypovitaminosis D and elevated serum alkaline phosphatase in elderly Irish people, Am J Clin Nutr, 41, 101, 10.1093/ajcn/41.1.101 Francis, 1996, A comparison of the effects of alfacalcidol treatment and vitamin D2 supplementation on calcium absorption in elderly women with vertebral fractures, Osteoporos Int, 6, 284, 10.1007/BF01623386 Sorva, 1991, Effects of vitamin D and calcium on markers of bone metabolism in geriatric patients with low serum 25-hydroxyvitamin D levels, Calcif Tissue Int, 49, S88, 10.1007/BF02555103 Honkanen, 1990, The necessity and safety of calcium and vitamin D in the elderly, J Am Geriatr Soc, 38, 862, 10.1111/j.1532-5415.1990.tb05700.x MacLennan, 1977, Vitamin D supplements and 25-hydroxy vitamin D concentrations in the elderly, Br Med J, 2, 859, 10.1136/bmj.2.6091.859 Himmelstein, 1990, Vitamin D supplementation in elderly nursing home residents increases 25(OH)D but not 1,25(OH)2D, Am J Clin Nutr, 52, 701, 10.1093/ajcn/52.4.701 Nordin, 1985, A prospective trial of the effect of vitamin D supplementation on metacarpal bone loss in elderly women, Am J Clin Nutr, 42, 470, 10.1093/ajcn/42.3.470 Papapoulos, 1980, Metabolites of vitamin D in human vitamin-D deficiency: effect of vitamin D3 or 1,25-dihydroxycholecalciferol, Lancet, 2, 612, 10.1016/S0140-6736(80)90283-4 Tjellesen, 1986, Serum concnetration of vitamin D metabolites during treatment with vitamin D2 and D3 in normal premenopausal women, Bone Miner, 1, 407 Clements, 1992, The role of 1,25-dihydroxyvitamin D in the mechanism of acquired vitamin D deficiency, Clin Endocrinol, 37, 17, 10.1111/j.1365-2265.1992.tb02278.x Mason, 1980, A simplified assay for dihydroxylated vitamin D metabolites in human serum: application to hyper- and hypovitaminosis D, Clin Chem, 26, 444, 10.1093/clinchem/26.3.444 Gertner, 1977, 25-hydroxyvitamin D levels in patients treated with high-dosage ergo- and cholecalciferol, Clin Pathol, 30, 144, 10.1136/jcp.30.2.144 Counts, 1975, Vitamin D intoxication in an anephric child, Ann Intern Med, 82, 196, 10.7326/0003-4819-82-2-196 Hughes, 1976, Radioligand receptor assay for 25-hydroxyvitamin D2/D3 and 1 alpha, 25-dihydroxyvitamin D2/D3, J Clin Invest, 58, 61, 10.1172/JCI108459 Streck, 1979, Glucocorticoid effects in vitamin D intoxication, Arch Intern Med, 139, 974, 10.1001/archinte.1979.03630460018009 Davies, 1978, The continuing risk of vitamin-D intoxication, Lancet, 2, 621, 10.1016/S0140-6736(78)92838-6 Mawer, 1985, Vitamin D metabolism in patients intoxicated with ergocalciferol, Clin Sci, 68, 135, 10.1042/cs0680135 Allen, 1992, Calcinosis and metastatic calcification due to vitamin D intoxication. A case report and review, Horm Res, 37, 68, 10.1159/000182285 Rizzoli, 1994, Hypercalcemia and hyperosteolysis in vitamin D intoxication: effects of clodronate therapy, Bone, 15, 193, 10.1016/8756-3282(94)90707-2 Pettifor, 1995, Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity, Ann Intern Med, 122, 511, 10.7326/0003-4819-122-7-199504010-00006 Heaney, 1997, Calcium absorptive effects of vitamin D and its major metabolites, J Clin Endocrinol Metab, 82, 4111 Heikinheimo, 1992, Annual injection of vitamin D and fractures of aged bones, Calcif Tissue Int, 51, 105, 10.1007/BF00298497 Davies, 1985, A possible link between vitamin D deficiency and impaired host defence to Mycobacterium tuberculosis, Tubercle, 66, 301, 10.1016/0041-3879(85)90068-6 Matsuoka, 1992, Elevation of blood vitamin D2 levels does not impede the release of vitamin D3 from the skin, Metabolism, 41, 1257, 10.1016/0026-0495(92)90018-6 Whyte, 1979, Vitamin D bioavailability: serum 25-hydroxyvitamin D levels in man after oral, subcutaneous, intramuscular, and intravenous vitamin D administration, J Clin Endocrinol Metab, 48, 906, 10.1210/jcem-48-6-906 Stern, 1981, Demonstration that circulating 1 α, 25-dihydroxyvitamin D is loosely regulated in normal children, J Clin Invest, 68, 1374, 10.1172/JCI110386 Scragg, 1995, Serum 25-hydroxycholecalciferol concentration in newly detected hypertension, Am J Hypertens, 8, 429, 10.1016/0895-7061(94)00195-H Heikinheimo, 1991, Serum vitamin D level after an annual intramuscular injection of ergocalciferol, Calcif Tissue Int, 49, S87, 10.1007/BF02555102 Weisman, 1986, Single oral high-dose vitamin D3 prophylaxis in the elderly, J Am Geriatr Soc, 34, 515, 10.1111/j.1532-5415.1986.tb04243.x Burns, 1985, Single dose vitamin D treatment for osteomalacia in the elderly, Br Med J (Clin Res Ed), 290, 281, 10.1136/bmj.290.6464.281-a Dent, 1969, Nutritional osteomalacia, Q J Med, 38, 195 Lips, 1996, Prevention of hip fractures: drug therapy, Bone, 18, 159S, 10.1016/8756-3282(95)00497-1 Riggs, 1998, Long-term effects of calcium supplementation on serum parathyroid hormone level, bone turnover, and bone loss in elderly women, J Bone Miner Res, 13, 168, 10.1359/jbmr.1998.13.2.168 Holick, 1994, McCollum Award Lecture, 1994: Vitamin D—new horizons for the 21st century, Am J Clin Nutr, 60, 619, 10.1093/ajcn/60.4.619 Lefkowitz, 1994, Sunlight, vitamin D, and ovarian cancer mortality rates in US women, Int J Epidemiol, 23, 1133, 10.1093/ije/23.6.1133 Martinez, 1996, Calcium, vitamin D, and the occurrence of colorectal cancer among women, J Natl Cancer Inst, 88, 1375, 10.1093/jnci/88.19.1375 Tangrea, 1997, Serum levels of vitamin D metabolites and the subsequent risk of colon and rectal cancer in Finnish men, Cancer Causes Control, 8, 615, 10.1023/A:1018450531136 Garland, 1991, Can colon cancer incidence and death rates be reduced with calcium and vitamin D?, Am J Clin Nutr, 54, 193S, 10.1093/ajcn/54.1.193S Emerson, 1992, Colorectal cancer and solar radiation, Cancer Causes Control, 3, 95, 10.1007/BF00051919 Schwartz, 1992, Multiple sclerosis and prostate cancer: what do their similar geographies suggest?, Neuroepidemiology, 11, 244, 10.1159/000110937 Hanchette, 1992, Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation, Cancer, 70, 2861, 10.1002/1097-0142(19921215)70:12<2861::AID-CNCR2820701224>3.0.CO;2-G Ainsleigh, 1993, Beneficial effects of sun exposure on cancer mortality, Prev Med, 22, 132, 10.1006/pmed.1993.1010 Hayes, 1997, Vitamin D and multiple sclerosis, Proc Soc Exp Biol Med, 216, 21, 10.3181/00379727-216-44153A McAlindon, 1996, Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study, Ann Intern Med, 125, 353, 10.7326/0003-4819-125-5-199609010-00001 Rostand, 1997, Ultraviolet light may contribute to geographic and racial blood pressure differences, Hypertension, 30, 150, 10.1161/01.HYP.30.2.150 McMurray, 1990, Micronutrient status and immune function in tuberculosis, Ann N Y Acad Sci, 587, 59, 10.1111/j.1749-6632.1990.tb00134.x Muhe, 1997, Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children, Lancet, 349, 1801, 10.1016/S0140-6736(96)12098-5 Gann, 1996, Circulating vitamin D metabolites in relation to subsequent development of prostate cancer, Cancer Epidemiol Biomarkers Prev, 5, 121 Braun, 1995, Prostate cancer and prediagnostic levels of serum vitamin D metabolites (Maryland, United States), Cancer Causes Control, 6, 235, 10.1007/BF00051795 Bhattacharyya, 1973, Comparative studies on the 25-hydroxylation of vitamin D3 and dihydrotachysterol 3, J Biol Chem, 248, 2974, 10.1016/S0021-9258(19)43996-3 Clements, 1987, A new mechanism for induced vitamin D deficiency in calcium deprivation, Nature, 325, 62, 10.1038/325062a0 Tomon, 1990, Expression of 25-hydroxyvitamin D3–24-hydroxylase activity in Caco-2 cells. An in vitro model of intestinal vitamin D catabolism, Endocrinology, 126, 2868, 10.1210/endo-126-6-2868 Vieth, 1987, Low dietary calcium reduces 25-hydroxycholecalciferol in plasma of rats, J Nutr, 117, 914, 10.1093/jn/117.5.914 Clements, 1987, Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism, Clin Sci, 73, 659, 10.1042/cs0730659 Dusso, 1994, Extrarenal production of calcitriol, Semin Nephrol, 14, 144 Jacobus, 1992, Hypervitaminosis D associ ated with drinking milk, N Engl J Med, 326, 1173, 10.1056/NEJM199204303261801 Sterkel, 1998, Bone density and vitamin D intoxication, Ann Intern Med, 128, 507, 10.7326/0003-4819-128-6-199803150-00025 Kenna, 1998, Bone density and vitamin D intoxication, Ann Intern Med, 128, 507, 10.7326/0003-4819-128-6-199803150-00026 Adams, 1998, Bone density and vitamin D intoxication, Ann Intern Med, 128, 508, 10.7326/0003-4819-128-6-199803150-00027 Moon, 1992, Hypothesis: etiology of atherosclerosis and osteoporosis: are imbalances in the calciferol endocrine system implicated?, J Am Coll Nutr, 11, 567, 10.1080/07315724.1992.10718263 Jeans, 1938, The effect of vitamin D on linear growth in infancy: II. The effect of intakes above 1,800 U.S.P. units daily, J Pediatr, 13, 730, 10.1016/S0022-3476(38)80162-1 Woolliscroft, 1983, Megavitamins: fact and fancy, Dis Mon, 29, 1, 10.1016/0011-5029(83)90001-9 Eager, 1948, Intoxication with vitamin D, J Clin Endocrinol, 8, 895, 10.1210/jcem-8-11-895 Narang, 1984, Role of vitamin D in pulmonary tuberculosis, J Assoc Physicians India, 32, 185 Bell, 1988, Evidence of probable role for 25-hydroxyvitamin D in the regulation of human calcium metabolism, J Bone Miner Res, 3, 489, 10.1002/jbmr.5650030503 Barger-Lux, 1995, An investigation of sources of variation in calcium absorption efficiency (published erratum appears in J Clin Endocrinol Metab 1995;80:2068), J Clin Endocrinol Metab, 80, 406 Vieth, 1990, The mechanisms of vitamin D toxicity, Bone Miner, 11, 267, 10.1016/0169-6009(90)90023-9 Fraser, 1983, The physiological economy of vitamin D, Lancet, 1, 969, 10.1016/S0140-6736(83)92090-1 Haddad, 1993, Human plasma transport of vitamin D after its endogenous synthesis, J Clin Invest, 91, 2552, 10.1172/JCI116492 Bell, 1998, Renal and nonrenal 25-hydroxyvitamin D-1alpha-hydroxylases and their clinical significance, J Bone Miner Res, 13, 350, 10.1359/jbmr.1998.13.3.350 Silverberg, 1997, Primary hyperparathyroidism: still evolving?, J Bone Miner Res, 12, 856, 10.1359/jbmr.1997.12.5.856 Kleeman, 1987, Is the clinical expression of primary hyperparathyroidism a function of the long-term vitamin D status of the patient?, Miner Electrolyte Metab, 13, 305 Lumb, 1974, Parathyroid function in human vitamin D deficiency and vitamin D deficiency in primary hyperparathyroidism, Am J Med, 56, 833, 10.1016/0002-9343(74)90812-2 Vieth, 1991, Relevance of vitamin D metabolite concentrations in supporting the diagnosis of primary hyperparathyroidism, Surgery, 110, 1043 Johnson, 1980, Prophylactic vitamin D in the elderly, Age Ageing, 9, 121, 10.1093/ageing/9.2.121 Lockefeer, 1990, Vitamin D poisoning; real and spurious, Ned Tijdschr Geneeskd, 134, 1931 Karmali, 1990, Intermittent hypercalcaemia and vitamin D sensitivity in Hodgkin's disease, Postgrad Med J, 66, 757, 10.1136/pgmj.66.779.757