Ziv Shulman1, Alexander D. Gitlin1, Jason S. Weinstein2, Begoña Lainez2, Enric Esplugues3, Richard A. Flavell3,4, Joseph Craft3,2, Michel C. Nussenzweig4,1
1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
2Department of Internal Medicine (Rheumatology), School of Medicine, Yale University, New Haven, CT 06520, USA.
3Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA
4Howard Hughes Medical Institute (HHMI).
Tóm tắt
T and B cells' intricate molecular dance
Generating high-affinity antibodies to fight infection is no easy task. To do so requires multiple steps, including T cells interacting with antibody-producing B cells in lymph nodes. These interactions select B cells expressing high-affinity antibodies for further proliferation, ensuring that the immune response generates high-affinity antibodies in large quantities. Shulman
et al.
use fluorescent live-cell imaging in mice to determine the molecular details of these interactions. They find that T cells engage B cells in short-lived mobile contacts during selection. These contacts cause T cells to flux calcium and produce proteins called cytokines, which probably drive B cells to proliferate and produce high-affinity antibodies.
Science
, this issue p.
1058
