Autoantibodies to Zona Pellucida: A Possible Cause for Infertility in Women

American Association for the Advancement of Science (AAAS) - Tập 197 Số 4308 - Trang 1082-1084 - 1977
C. Alex Shivers1, Bonnie S. Dunbar1
1Department of Zoology, University of Tennessee, Knoxville 37916

Tóm tắt

Human and pig ovaries were tested by agar gel diffusion and found to contain several cross-reacting (common) antigens. At least one common antigen was located in the zona pellucida as determined by indirect immunofluorescence. Serum samples from 22 infertile women were tested on pig eggs by immunofluorescence, and six of these samples produced strong and nine produced moderate reactions with the zona pellucida. The autoantibodies may be responsible for infertility in these women.

Từ khóa


Tài liệu tham khảo

AUSTIN C.R. MAMMALIAN EGG (1961).

BARROS, C, POLYSPERMY-PREVENTING MECHANISMS IN GOLDEN-HAMSTER EGG, JOURNAL OF EXPERIMENTAL ZOOLOGY 180: 251 (1972).

BRADEN, AWH, THE REACTION OF THE ZONA PELLUCIDA TO SPERM PENETRATION, AUSTRALIAN JOURNAL OF BIOLOGICAL SCIENCES 7: 391 (1954).

DUDKIEWICZ, A.B., INHIBITION OF IMPLANTATION IN GOLDEN-HAMSTER BY ZONA-PRECIPITATING ANTIBODY, FERTILITY AND STERILITY 26: 686 (1975).

GARAVAGNO, A, SOME CHARACTERISTICS OF ZONA PELLUCIDA ANTIGEN IN HAMSTER, JOURNAL OF EXPERIMENTAL ZOOLOGY 189: 37 (1974).

GLASS L.E. ADV BIOSCIENCES 6 (1970).

GLASS, L.E., IMMUNOLOGICAL APPROACH TO CONTRACEPTION - LOCALIZATION OF ANTIEMBRYO AND ANTIZONA PELLUCIDA SERUM DURING MOUSE PREIMPLANTATION DEVELOPMENT, FERTILITY AND STERILITY 25: 484 (1974).

GOLDBERG, E, IMMUNOLOGICAL APPROA 7: 202 (1974).

GWATKIN, RBL, STUDIES ON ZONA PELLUCIDA OF MOUSE EGG, JOURNAL OF REPRODUCTION AND FERTILITY 6: 325 (1963).

HANADA, A, PENETRATION OF ZONA-FREE EGGS BY SPERMATOZOA OF DIFFERENT SPECIES, BIOLOGY OF REPRODUCTION 6: 300 (1972).

JILEK, F, ANTIBODIES AGAINST MOUSE OVARIES AND THEIR EFFECT ON FERTILIZATION INVITRO AND INVIVO IN MOUSE, JOURNAL OF REPRODUCTION AND FERTILITY 42: 377 (1975).

JONES, W.R., IMMUNOLOGICAL APPROA 7: 376 (1974).

MINTZ B ADV BIOSCIENCES 6 (1970).

OIKAWA, T, BLOCK OF HAMSTER FERTILIZATION BY ANTIOVARY ANTIBODY, JOURNAL OF REPRODUCTION AND FERTILITY 45: 487 (1975).

OWNBY, C.L., ANTIGENS OF HAMSTER OVARY AND EFFECTS OF ANTI-OVARY SERUM ON EGGS, BIOLOGY OF REPRODUCTION 6: 310 (1972).

ROSE, N.R., CLINICAL & EXPERIMENTAL IMMUNOLOGY 23: 175 (1976).

SACCO A.G. COMMUNICATION.

SACCO, A.G., ANTIGENS OF RABBIT OVARY, OVIDUCT AND UTERUS, JOURNAL OF REPRODUCTION AND FERTILITY 32: 403 (1973).

SACCO, A.G., LOCALIZATION OF TISSUE-SPECIFIC ANTIGENS IN RABBIT OVARY, OVIDUCT AND UTERUS BY FLUORESCENT-ANTIBODY TECHNIQUE, JOURNAL OF REPRODUCTION AND FERTILITY 32: 415 (1973).

SACCO, A.G., COMPARISON OF ANTIGENS IN OVARY, OVIDUCT AND UTERUS OF RABBIT AND OTHER MAMMALIAN SPECIES, JOURNAL OF REPRODUCTION AND FERTILITY 32: 421 (1973).

SHIVERS, C.A., IMMUNOLOGICAL APPROA 7: 223 (1974).

10.1126/science.178.4066.1211

STEVENS, V.C., IMMUNOLOGICAL APPROA 7: 357 (1976).

TALWAR G.P. CONTRACEPTION 13 (1976).

TSUNODA, Y, EFFECT OF ANTI-RAT OVARY ANTISERUM ON FERTILIZATION OF RAT, MOUSE AND HAMSTER EGGS INVIVO AND INVITRO, BIOLOGY OF REPRODUCTION 14: 354 (1976).

Yanagimachi, R., Proceedings of the National Academy of Sciences of the United States of America 73: 2405 (1976).

YANAGIMACHI, R, PENETRATION OF GUINEA-PIG SPERMATOZOA INTO HAMSTER EGGS IN-VITRO, JOURNAL OF REPRODUCTION AND FERTILITY 28: 477 (1972).

Thông tin
Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 197 Số 4308

1082-1084

Thông tin tác giả