All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans

Nutrition Research - Tập 31 - Trang 262-269 - 2011
Janet Zand1, Frank Lanza2, Harsha K. Garg3, Nathan S. Bryan1,3
1Neogenis Laboratories, Inc, Austin, TX 78746, USA
2Houston Institute for Clinical Research, Houston, TX 77074, USA
3Texas Therapeutics Institute at the Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler St 530C, Houston, TX 77030, USA

Tài liệu tham khảo

Murad, 2006, Shattuck lecture. Nitric oxide and cyclic GMP in cell signaling and drug development, N Engl J Med, 355, 2003, 10.1056/NEJMsa063904 Schachinger, 2000, Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease, Circulation, 101, 1899, 10.1161/01.CIR.101.16.1899 Halcox, 2002, Prognostic value of coronary vascular endothelial dysfunction, Circulation, 106, 653, 10.1161/01.CIR.0000025404.78001.D8 Bugiardini, 2004, Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms, Circulation, 109, 2518, 10.1161/01.CIR.0000128208.22378.E3 Lerman, 2005, Endothelial function: cardiac events, Circulation, 111, 363, 10.1161/01.CIR.0000153339.27064.14 Kleinbongard, 2003, Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals, Free Radic Biol Med, 35, 790, 10.1016/S0891-5849(03)00406-4 Kleinbongard, 2006, Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans, Free Radic Biol Med, 40, 295, 10.1016/j.freeradbiomed.2005.08.025 Schulman, 2006, L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial, Jama, 295, 58, 10.1001/jama.295.1.58 Bode-Boger, 2005, Organic nitrates in cardiovascular disease, Cell Mol Biol (Noisy-le-grand), 51, 307 Parker, 2003, Therapy with nitrates: increasing evidence of vascular toxicity, J Am Coll Cardiol, 42, 1835, 10.1016/j.jacc.2003.08.019 Nakamura, 1999, Long-term nitrate use may be deleterious in ischemic heart disease: a study using the databases from two large-scale postinfarction studies, American Heart Journal, 138, 577, 10.1016/S0002-8703(99)70163-8 Kanamasa, 2002, Long-term, continuous treatment with both oral and transdermal nitrates increases cardiac events in healed myocardial infarction patients, Angiology, 53, 399, 10.1177/000331970205300405 2009, 238 Hord, 2009, Food sources of nitrates and nitrites: the physiologic context for potential health benefits, Am J Clin Nutr, 90, 1, 10.3945/ajcn.2008.27131 Spiegelhalder, 1976, Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds, Food Cosmet Toxicol, 14, 545, 10.1016/S0015-6264(76)80005-3 Duncan, 1995, Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate [see comments], Nat Med, 1, 546, 10.1038/nm0695-546 Lundberg, 1994, Intragastric nitric oxide production in humans: measurements in expelled air, Gut, 35, 1543, 10.1136/gut.35.11.1543 Lundberg, 2004, Inorganic nitrate is a possible source for systemic generation of nitric oxide, Free Radic Biol Med, 37, 395, 10.1016/j.freeradbiomed.2004.04.027 Benjamin, 1994, Stomach NO synthesis, Nature, 368, 502, 10.1038/368502a0 Kapil, 2010, Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO, Hypertension, 56, 274, 10.1161/HYPERTENSIONAHA.110.153536 Larsen, 2006, Effects of dietary nitrate on blood pressure in healthy volunteers, N Engl J Med, 355, 2792, 10.1056/NEJMc062800 Webb, 2008, Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite, Hypertension, 51, 784, 10.1161/HYPERTENSIONAHA.107.103523 Stokes, 2009, Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction, Am J Physiol Heart Circ Physiol, 296, H1281, 10.1152/ajpheart.01291.2008 Bryan, 2007, Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury, Proc Natl Acad Sci U S A, 104, 19144, 10.1073/pnas.0706579104 Lundberg, 2008, The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics, Nat Rev Drug Discov, 7, 156, 10.1038/nrd2466 Bailey, 2011, Dietary supplement use in the United States, 2003-2006, J Nutr, 141, 261, 10.3945/jn.110.133025 Bryan, 2007, Methods to detect nitric oxide and its metabolites in biological samples, Free Radic Biol Med, 43, 645, 10.1016/j.freeradbiomed.2007.04.026 Vanhatalo, 2010, Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise, Am J Physiol Regul Integr Comp Physiol, 10.1152/ajpregu.00206.2010 Feelisch, 2008, Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems, J Biol Chem, 283, 33927, 10.1074/jbc.M806654200 Tang, 2009, Nitric oxide bioactivity of traditional Chinese medicines used for cardiovascular indications, Free Radic Biol Med, 47, 835, 10.1016/j.freeradbiomed.2009.06.024 Bartsch, 1993, Inhibition of nitrosation, Basic Life Sci, 61, 27 Esper, 2006, Endothelial dysfunction: a comprehensive appraisal, Cardiovasc Diabetol, 5, 4, 10.1186/1475-2840-5-4 Ignarro, 2002, Nitric oxide as a unique signaling molecule in the vascular system: a historical overview, J Physiol Pharmacol, 53, 503 Herman, 2005, Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis, Eur Heart J, 26, 1945, 10.1093/eurheartj/ehi333 Taddei, 2001, Age-related reduction of NO availability and oxidative stress in humans, Hypertension, 38, 274, 10.1161/01.HYP.38.2.274 Egashira, 1993, Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans, Circulation, 88, 77, 10.1161/01.CIR.88.1.77 Gerhard, 1996, Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans, Hypertension, 27, 849, 10.1161/01.HYP.27.4.849 Lundberg, 2009, Nitrate and nitrite in biology, nutrition and therapeutics, Nat Chem Biol, 5, 865, 10.1038/nchembio.260 Carlstrom, 2010, Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice, Proc Natl Acad Sci U S A, 10.1073/pnas.1008872107 Shanthi, 1994, Hypolipidemic activity of tincture of Crataegus in rats, Indian J Biochem Biophys, 31, 143 Sadovsky, 2009, Prescription omega-3-acid ethyl esters for the treatment of very high triglycerides, Postgrad Med, 121, 145, 10.3810/pgm.2009.07.2020 Bryan, 2008, Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase–deficient mice, Free Radic Biol Med, 45, 468, 10.1016/j.freeradbiomed.2008.04.040 Shiva, 2007, Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer, J Exp Med, 204, 2089, 10.1084/jem.20070198 Sobko, 2005, Gastrointestinal bacteria generate nitric oxide from nitrate and nitrite, Nitric Oxide, 13, 272, 10.1016/j.niox.2005.08.002 World Health Organization: Report on diet, nutrition and the prevention of chronic diseases. 2003.