Topologic mixing on a microfluidic chip

Applied Physics Letters - Tập 84 Số 12 - Trang 2193-2195 - 2004
Hao Chen1, Jens‐Christian Meiners1
1Department of Physics and Biophysics Research Division, University of Michigan, Ann Arbor, Michigan 48109-1120

Tóm tắt

Mixing two liquids on a microfluidic chip is notoriously hard because the small dimensions and velocities on the chip effectively prevent turbulence. We present a topological mixing scheme that exploits the laminarity of the flow to repeatedly fold the flow and exponentially increase the concentration gradients to obtain fast and efficient mixing by diffusion. It is based on helical flow channels with opposite chiralities that split, rotate, and recombine the fluid stream in a topology reminiscent of a series of Möbius bands. This geometry is realized in a simple six-stage, two-layer elastomer structure with a footprint of 400 μm×300 μm per stage that mixes two solutions efficiently at Reynolds numbers between 0.1 and 2. This represents more than an order of magnitude reduction in the size of microfluidic mixers that can be manufactured in standard multilayer soft lithography techniques.

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Tài liệu tham khảo

2000, Science, 288, 113, 10.1126/science.288.5463.113

2002, Science, 298, 580, 10.1126/science.1076996

2002, Electrophoresis, 23, 1531, 10.1002/1522-2683(200205)23:10<1531::AID-ELPS1531>3.0.CO;2-D

2002, Science, 295, 647, 10.1126/science.1066238

2000, J. Microelectromech. Syst., 9, 190, 10.1109/84.846699

2003, Nat. Mater., 2, 265, 10.1038/nmat863

1999, Anal. Commun., 36, 213, 10.1039/a902237f

2003, AIChE J., 49, 566, 10.1002/aic.690490304

2001, Anal. Chem., 73, 1240, 10.1021/ac001132d

1998, Anal. Chem., 70, 4974, 10.1021/ac980656z

2003, Anal. Chem., 75, 5287, 10.1021/ac034179i

2003, Angew. Chem., Int. Ed., 42, 768, 10.1002/anie.200390203

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Thông tin xuất bản

Applied Physics Letters

Tập 84 Số 12

2193-2195

Thông tin tác giả