Use of multiple dipole analysis for the classification of benign rolandic epilepsy
Tóm tắt
The clinical literature has suggested that while the clinical features and presentation of benign rolandic epilepsy in children (BREC) are known, the neuronal mechanism of the epileptic focus is poorly understood. Classification of clinical subtypes is usually made by determining whether there are supplementary clinical signs of brain damage, in which case the epilepsy is classified as non-benign or "atypical". Studies of EEG findings in BREC have suggested that the source of the epilepsy is in the Rolandic fissure. We investigated dipole source modelling in 24 children, comparing the results of one and two dipole models. The results indicate that atypical BREC patients have a more complex distribution of dipoles and that single dipole fits may be more predictive of typical BREC than multiple dipole fits. The implications of these results are discussed.
Tài liệu tham khảo
Aicardi, J. Epileptic syndromes in childhood. Epilepsia, 1988, 29, Supp. 3, s1-s5.
Aicardi, J. & Chevrie, J. J. Atypical benign partial epilepsy of childhood. Developmental Medicine and Child Neurology, 1982, 24, 281–292.
Beaussart, M. Benign rolandic epilepsy of children with rolandic (centro-temporal) paroxysmal foci: A clinical entity. Study of 221 cases. Epilepsia, 1972, 13, 795–811.
Beydoun, A., Garofalo, E. A., Drury, I. Comparison between Typical and Atypical cases of benign rolandic epilepsy. Epilepsia, 1989, 30:5, 656.
Blom, S., Heijbel, J., & Bergfors, P. G. Benign epilepsy of children with centro-temporal EEG foci. Prevalence and follow-up study of 40 patients. Epilepsia, 1972, 13, 609–619.
Gregory, D., Wong, P.K.H. Topographic analysis of the centrotemporal discharges in benign rolandic epilepsy of childhood. Epilepsia, 1984, 25(6):705–711.
Heijbel, J., Blom, S., Rasmuson, M. Benign epilepsy of childhood with centrotemporal EEG foci. A genetic study. Epilepsia, 1975, 16, 285–293.
Nelder, J. A., & Mead, R. Computer Journal, 1965, 7, 308.
O'Donohoe,, N. V. Epilepsies of Childhood, 2nd edition. Butterworths: London, 1985.
Stok, C. J. The inverse problem in EEG and MEG with application to visual evoked responses. Doctoral dissertation, University of Twente. Druk: Krips Repro Meppel, 1986.
Wong, P. K. H. Stability of source estimates in rolandic spikes. Brain Topography, 1989, 2:1/2, 31–36.
Wong, P. K. H., Bencivenga, R., & Gregory, D. Statistical classification of spikes in benign rolandic epilepsy. Brain Topography, 1988, 1:2, 123–129.
Wong, P. K. H., & Weinberg, H. Source estimation of scalp EEG focus. In G. Pfurtscheller and F. H. Lopes da Silva (Eds.), Functional Brain Imaging, pp. 89–95. Hans Huber: Toronto, 1988.