A critical role of autocrine sonic hedgehog signaling in human CD138+ myeloma cell survival and drug resistance

Blood - Tập 124 - Trang 2061-2071 - 2014
Zhiqiang Liu1, Jingda Xu1, Jin He1, Yuhuan Zheng1, Haiyan Li1, Yong Lu1, Jianfei Qian1, Pei Lin1, Donna M. Weber1, Jing Yang1, Qing Yi1
1Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Tóm tắt

Key Points

CD138+ MM cells are a major source of SHH. Autocrine SHH enhances MM drug resistance.


Tài liệu tham khảo

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