Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference

Hepatology - Tập 37 - Trang 1202-1219 - 2003
Brent A. Neuschwander-Tetri1, Stephen H. Caldwell1
1From the Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St. Louis, MO and the Division of GI/Hepatology, University of Virginia Health Sciences Center, Charlottesville, VA.

Tài liệu tham khảo

Ludwig, 1980, Mayo Clinic Proc, 55, 434 Farrell, 2002, Semin Liver Dis, 22, 185, 10.1055/s-2002-30106 Dixon, 2002, Gastroenterology, 122, 841, 10.1016/S0016-5085(02)80152-4 Cairns, 1983, Clin Sci, 65, 645, 10.1042/cs0650645 Dixon, 2001, Gastroenterology, 121, 91, 10.1053/gast.2001.25540 Rashid, 2000, J Pediatr Gastroenterol Nutr, 30, 48, 10.1097/00005176-200001000-00017 Manton, 2000, Med J Aust, 173, 476, 10.5694/j.1326-5377.2000.tb139299.x Matteoni, 1999, Gastroenterology, 116, 1413, 10.1016/S0016-5085(99)70506-8 Saadeh, 2002, Gastroenterology, 123, 745, 10.1053/gast.2002.35354 Lee, 1995, Hepatology, 21, 1742 Bacon, 1994, Gastroenterology, 107, 1103, 10.1016/0016-5085(94)90235-6 Contos, 2001, Liver Transpl, 7, 363, 10.1053/jlts.2001.23011 Powell, 1990, Hepatology, 11, 74, 10.1002/hep.1840110114 Caldwell, 1999, Hepatology, 29, 664, 10.1002/hep.510290347 Poonawala, 2000, Hepatology, 32, 689, 10.1053/jhep.2000.17894 Ong, 2001, Liver Transpl, 7, 797, 10.1053/jlts.2001.24644 Mathiesen, 1999, Scand J Gastroenterol, 34, 85, 10.1080/00365529950172880 Daniel, 1999, Am J Gastroenterol, 94, 3010, 10.1111/j.1572-0241.1999.01451.x Clark, 2002, Gastroenterology, 122, 1649, 10.1053/gast.2002.33573 Sorbi, 2000, Am J Gastroenterol, 95, 3206, 10.1111/j.1572-0241.2000.03293.x Byron, 1996, Hepatology, 24, 813, 10.1002/hep.510240410 Hilden, 1977, Scand J Gastroenterol, 12, 593, 10.3109/00365527709181339 Bellentani, 2000, Ann Intern Med, 132, 112, 10.7326/0003-4819-132-2-200001180-00004 Wanless, 1990, Hepatology, 12, 1106, 10.1002/hep.1840120505 Andersen, 1984, Int J Obes Relat Metab Disord, 8, 97 Andersen, 1984, Int J Obes Relat Metab Disord, 8, 107 Ratziu, 2000, Gastroenterology, 118, 1117, 10.1016/S0016-5085(00)70364-7 García-Monzón, 2000, J Hepatol, 33, 716, 10.1016/S0168-8278(00)80301-3 Braillon, 1985, Gut, 26, 133, 10.1136/gut.26.2.133 Klain, 1989, Hepatology, 10, 873, 10.1002/hep.1840100521 Lee, 1989, Hum Pathol, 20, 594, 10.1016/0046-8177(89)90249-9 Marchesini, 1999, Am J Med, 107, 450, 10.1016/S0002-9343(99)00271-5 Falchuk, 1980, Gastroenterology, 78, 535, 10.1016/0016-5085(80)90869-0 Silverman, 1989, Pathol Annual, 24, 275 Silverman, 1990, Am J Gastroenterol, 85, 1349 Angulo, 1999, Hepatology, 30, 1356, 10.1002/hep.510300604 Saksena, 2002, Hepatology, 36, 222a Nanji, 1986, Enzyme, 36, 266, 10.1159/000469304 : Obesity and cryptogenic cirrhosis. In: , , eds. Falk Symposium: Steatohepatitis (ASH and NASH). Volume 121. Norwell, MA: Kluwer Academic Publishers, 2001;151. Propst, 1995, Dig Dis Sci, 40, 1805, 10.1007/BF02212706 Sasaki, 1989, Diabetes Res Clin Pract, 7, 33, 10.1016/0168-8227(89)90042-9 Hilden, 1973, Acta Med Scand, 194, 485, 10.1111/j.0954-6820.1973.tb19478.x Nair, 2002, Hepatology, 36, 774, 10.1053/jhep.2002.33713 2002, Hepatology, 36, 150 Bugianesi, 2002, Gastroenterology, 123, 134, 10.1053/gast.2002.34168 Ratziu, 2002, Hepatology, 35, 1485, 10.1053/jhep.2002.33324 Ong, 2002, [Letter; Comment] Gastroenterology, 123, 375, 10.1053/gast.2002.34453 Strauss, 2000, J Pediatr, 136, 727 Dulloo, 2002, Science, 297, 780, 10.1126/science.1074923 Bachman, 2002, Science, 297, 843, 10.1126/science.1073160 Caldwell, 2002, Am J Gastroenterol, 97, 1496, 10.1111/j.1572-0241.2002.05795.x Santos, 2001, Gastroenterology, 120, a117, 10.1016/S0016-5085(08)80575-6 Squires, 2000, Hepatology, 32, 418a, 10.1053/jhep.2000.9408 Kemmer, 2001, Gastroenterology, 120, a117, 10.1016/S0016-5085(08)80576-8 Weston, 2002, Hepatology, 36, 405a Perry, 2000, J Appl Physiol, 89, 636, 10.1152/jappl.2000.89.2.636 Struben, 2000, Am J Med, 108, 9, 10.1016/S0002-9343(99)00315-0 Willner, 2001, Am J Gastroenterol, 96, 2957, 10.1111/j.1572-0241.2001.04667.x Lee, 1998, Korean J Intern Med, 13, 12 Banerji, 1999, J Clin Endocrinol Metab, 84, 137 Pagano, 2002, Hepatology, 35, 367, 10.1053/jhep.2002.30690 Chitturi, 2002, Hepatology, 35, 373, 10.1053/jhep.2002.30692 Cortez-Pinto, 1999, Clin Nutr, 18, 353, 10.1016/S0261-5614(99)80015-6 Knobler, 1999, QJM, 92, 73, 10.1093/qjmed/92.2.73 Ikai, 1995, J Hum Hypertens, 9, 101 Lobo, 2000, Ann Intern Med, 132, 989, 10.7326/0003-4819-132-12-200006200-00010 Kuczmarski, 1989, Am J Clin Nutr, 50, 1150, 10.1093/ajcn/50.5.1150 Powell, 1989, Gastroenterology, 97, 1022, 10.1016/0016-5085(89)91513-8 Garg, 2000, Am J Med, 108, 143, 10.1016/S0002-9343(99)00414-3 De Craemer, 1995, Hepatology, 22, 744, 10.1002/hep.1840220309 Caldwell, 1999, J Hepatol, 31, 430, 10.1016/S0168-8278(99)80033-6 Sanyal, 2001, Gastroenterology, 120, 1183, 10.1053/gast.2001.23256 Bohan, 2000, Hepatology, 32, 387a Pessayre, 2001, Semin Liver Dis, 21, 57, 10.1055/s-2001-12929 Wasserman, 2001, Semin Liver Dis, 21, 115, 10.1055/s-2001-12934 Van Steenbergen, 1995, Int J Obes Relat Metab Disord, 19, s27 Vila, 2000, Biochem Biophys Res Commun, 278, 800, 10.1006/bbrc.2000.3828 Mansouri, 1997, Gastroenterology, 113, 599, 10.1053/gast.1997.v113.pm9247482 Cotrim, 1999, Liver, 19, 299, 10.1111/j.1478-3231.1999.tb00053.x Redlich, 1990, Gastroenterology, 99, 748, 10.1016/0016-5085(90)90964-3 Cotrim, 2002, Hepatology, 36, 983a Chitturi, 2001, Semin Liver Dis, 21, 27, 10.1055/s-2001-12927 Simon, 1984, N Engl J Med, 311, 167, 10.1056/NEJM198407193110308 Cai, 2000, Am J Gastroenterol, 95, 277, 10.1111/j.1572-0241.2000.01708.x Pinto, 1995, J Hepatol, 23, 95, 10.1016/0168-8278(95)80316-5 Cote, 2002, N Engl J Med, 346, 811, 10.1056/NEJMoa012035 Dahl, 1971, Br Med J, 1, 625, 10.1136/bmj.1.5750.625 Cassagnou, 1996, Am J Gastroenterol, 91, 1291 Partin, 1974, Gastroenterology, 67, 107, 10.1016/S0016-5085(19)32931-2 Prati, 2002, Ann Intern Med, 137, 1, 10.7326/0003-4819-137-1-200207020-00006 Saltiel, 2001, Cell, 104, 517, 10.1016/S0092-8674(01)00239-2 Rothman, 1991, Science, 254, 573, 10.1126/science.1948033 Magnusson, 1992, J Clin Invest, 90, 1323, 10.1172/JCI115997 Kim, 2001, Proc Natl Acad Sci U S A, 98, 7522, 10.1073/pnas.121164498 Hotamisligil, 1995, J Clin Invest, 95, 2409, 10.1172/JCI117936 Uysal, 1997, Nature, 389, 610, 10.1038/39335 Yuan, 2001, Science, 293, 1673, 10.1126/science.1061620 Hundal, 2002, J Clin Invest, 109, 1321, 10.1172/JCI0214955 Barzilai, 1997, J Clin Invest, 100, 3105, 10.1172/JCI119865 Saxena, 2002, Hepatology, 35, 762, 10.1053/jhep.2002.32029 Ikejima, 2002, Gastroenterology, 122, 1399, 10.1053/gast.2002.32995 Steppan, 2001, Nature, 409, 307, 10.1038/35053000 Kondo, 2002, Diabetes, 51, 2325, 10.2337/diabetes.51.7.2325 Berg, 2001, Nat Med, 7, 947, 10.1038/90992 Hasegawa, 2001, Aliment Pharmacol Ther, 15, 1667, 10.1046/j.1365-2036.2001.01083.x Robertson, 2001, Am J Physiol, 281, g1135 Nanji, 2001, J Pharmacol Exp Ther, 299, 638 Fisher, 2002, J Biol Chem, 277, 17377, 10.1074/jbc.R100068200 Mensenkamp, 2001, Arterioscler Thromb Vasc Biol, 21, 1366, 10.1161/hq0801.093864 Davidson, 2000, Annu Rev Nutr, 20, 169, 10.1146/annurev.nutr.20.1.169 Leung, 2000, J Biol Chem, 275, 7515, 10.1074/jbc.275.11.7515 Bernard, 2000, Diabetologia, 43, 995, 10.1007/s001250051481 Bjorkegren, 2002, J Biol Chem, 277, 5476, 10.1074/jbc.M108514200 Charlton, 2002, Hepatology, 35, 898, 10.1053/jhep.2002.32527 Garg, 2002, J Clin Endocrinol Metab, 87, 3019, 10.1210/jcem.87.7.8736 Agarwal, 2002, Nat Genet, 31, 21, 10.1038/ng880 Agarwal, 2002, J Clin Endocrinol Metab, 87, 408 Shackleton, 2000, Nat Genet, 24, 153, 10.1038/72807 Shimano, 1996, J Clin Invest, 98, 1575, 10.1172/JCI118951 Yahagi, 2002, J Biol Chem, 277, 19353, 10.1074/jbc.M201584200 Arioglu Oral, 2002, N Engl J Med, 346, 570, 10.1056/NEJMoa012437 Dianzani, 1954, Biochim Biophys Acta, 14, 514, 10.1016/0006-3002(54)90232-2 Dianzani, 1957, Biochem J, 65, 116, 10.1042/bj0650116 Vendemiale, 2001, Hepatology, 33, 808, 10.1053/jhep.2001.23060 Cortez-Pinto, 1999, JAMA, 282, 1659, 10.1001/jama.282.17.1659 Baffy, 2002, Hepatology, 35, 753, 10.1053/jhep.2002.32028 Grove, 1997, Hepatology, 26, 143, 10.1002/hep.510260119 Valenti, 2002, Gastroenterology, 122, 274, 10.1053/gast.2002.31065 Day, 2002, J Hepatol, 36, 21, 10.1016/S0168-8278(02)80059-9 Järveläinen, 2001, Hepatology, 33, 1148, 10.1053/jhep.2001.24236 Koteish, 2001, Semin Liver Dis, 21, 89, 10.1055/s-2001-12932 Cohen, 2001, J Clin Invest, 108, 1113, 10.1172/JCI200113914 Heiman, 1997, Endocrinology, 138, 3859, 10.1210/endo.138.9.5366 Masuzaki, 2001, Science, 294, 2166, 10.1126/science.1066285 Lu, 2001, Proc Natl Acad Sci U S A, 98, 5560, 10.1073/pnas.091016398 Angulo, 2002, N Engl J Med, 346, 1221, 10.1056/NEJMra011775 Klein, 2002, Gastroenterology, 123, 882, 10.1053/gast.2002.35514 Pouliot, 1994, Am J Cardiol, 73, 460, 10.1016/0002-9149(94)90676-9 Brodkin, 1995, Occup Environ Med, 52, 679, 10.1136/oem.52.10.679 Redlich, 1997, Ann Intern Med, 127, 410, 10.7326/0003-4819-127-5-199709010-00014 Saksena, 1999, Hepatology, 30, 436a Bertram, 1990, S Afr Med J, 78, 15 Eden, 2002, Ann Intern Med, 137, 208, 10.7326/0003-4819-137-3-200208060-00015 Tuomilehto, 2001, N Engl J Med, 344, 1343, 10.1056/NEJM200105033441801 Jones, 2000, N Engl J Med, 343, 632, 10.1056/NEJM200008313430907 van Baak, 1999, Int J Obes Relat Metab Disord, 23, s11, 10.1038/sj.ijo.0800879 Hoppeler, 1999, Int J Obes Relat Metab Disord, 23, s7, 10.1038/sj.ijo.0800878 Eriksson, 1986, Acta Med Scand, 220, 83, 10.1111/j.0954-6820.1986.tb02733.x Ueno, 1997, J Hepatol, 27, 103, 10.1016/S0168-8278(97)80287-5 Keeffe, 1987, Dig Dis Sci, 32, 441, 10.1007/BF01296300 Palmer, 1990, Gastroenterology, 99, 1408, 10.1016/0016-5085(90)91169-7 Rozental, 1967, Am J Dig Dis, 12, 198, 10.1007/BF02233443 Drenick, 1970, N Engl J Med, 282, 829, 10.1056/NEJM197004092821502 Andersen, 1991, J Hepatol, 12, 224, 10.1016/0168-8278(91)90942-5 Vajro, 1994, J Pediatr, 125, 239, 10.1016/S0022-3476(94)70202-0 Vajro, 2000, J Pediatr, 136, 739, 10.1016/S0022-3476(00)26774-7 Kraus, 2002, N Engl J Med, 347, 1483, 10.1056/NEJMoa020194 Spieth, 2000, Arch Pediatr Adolesc Med, 154, 947, 10.1001/archpedi.154.9.947 Vessby, 2000, Br J Nutr, 83, s91, 10.1017/S000711450000101X Kurihara, 1994, Clin Ther, 16, 830 Nanji, 1995, Gastroenterology, 109, 547, 10.1016/0016-5085(95)90344-5 Lokesh, 1992, JPEN J Parenter Enteral Nutr, 16, 316, 10.1177/0148607192016004316 Lanza-Jacoby, 1992, JPEN J Parenter Enteral Nutr, 16, 353, 10.1177/0148607192016004353 Kolanowski, 1999, Drug Safety, 20, 119, 10.2165/00002018-199920020-00003 Harrison, 2002, Hepatology, 36, 406a Mun, 2001, Gastroenterology, 120, 669, 10.1053/gast.2001.22430 Luyckx, 1998, Int J Obes Relat Metab Disord, 22, 222, 10.1038/sj.ijo.0800571 Silverman, 1995, Am J Clin Pathol, 104, 23, 10.1093/ajcp/104.1.23 Ackerman, 1979, Surg Gynecol Obstetr, 149, 8 Drenick, 1982, Gastroenterology, 82, 535, 10.1016/S0016-5085(82)80403-4 Laurin, 1996, Hepatology, 23, 1464, 10.1002/hep.510230624 Guma, 1997, Hepatology, 26, 387a, 10.1016/S0168-8278(97)80057-8 Ceriani, 1998, Hepatology, 28, 386a Mendez-Sanchez, 2002, Hepatology, 36, 412a Antosiewicz, 1994, Exp Mol Pathol, 60, 173, 10.1006/exmp.1994.1016 Soltys, 2001, Hepatology, 34, 13, 10.1053/jhep.2001.25452 Lavine, 2000, J Pediatr, 136, 734, 10.1016/S0022-3476(00)05040-X Alvaro, 1995, Dig Dis Sci, 40, 1592, 10.1007/BF02285216 Lu, 1998, Gastroenterology, 114, 403, 10.1016/S0016-5085(98)70494-9 Colell, 1997, Hepatology, 26, 699 Abdelmalek, 2001, Am J Gastroenterol, 96, 2711, 10.1111/j.1572-0241.2001.04129.x Gulbahar, 2000, Gastroenterology, 118, a1444, 10.1016/S0016-5085(00)81671-6 Brown, 2001, N Engl J Med, 345, 1583, 10.1056/NEJMoa011090 Venkataramanan, 2000, Drug Metab Dispos, 28, 1270 Fu, 1998, Gastroenterology, 114, a1243, 10.1016/S0016-5085(98)85042-7 Azuma, 2001, Int Immunopharmacol, 1, 1867, 10.1016/S1567-5769(01)00112-6 Villa, 1997, Pharm Rev, 49, 99 Facchini, 2002, Gastroenterology, 122, 931, 10.1053/gast.2002.32403 DeFronzo, 1999, Ann Intern Med, 131, 281, 10.7326/0003-4819-131-4-199908170-00008 Caldwell, 2001, Am J Gastroenterol, 96, 519, 10.1111/j.1572-0241.2001.03553.x Acosta, 2001, Gastroenterology, 120, a546, 10.1016/S0016-5085(08)82715-1 Neuschwander-Tetri, 2002, Hepatology, 36, 379a Galli, 2002, Gastroenterology, 122, 1924, 10.1053/gast.2002.33666 Azuma, 2002, Hepatology, 36, 406a Sanyal, 2002, Hepatology, 36, a382 Vamecq, 1999, Lancet, 354, 141, 10.1016/S0140-6736(98)10364-1 Ribon, 1998, Proc Natl Acad Sci U S A, 95, 14751, 10.1073/pnas.95.25.14751 Kelly, 1999, Diabetes Care, 22, 288, 10.2337/diacare.22.2.288 Lenhard, 1997, Biochem Pharmacol, 54, 801, 10.1016/S0006-2952(97)00229-3 Aubert, 1997, Biochem Biophys Res Commun, 238, 606, 10.1006/bbrc.1997.7348 Arioglu, 2000, Ann Intern Med, 133, 263, 10.7326/0003-4819-133-4-200008150-00009 Lin, 2000, Nat Med, 6, 998, 10.1038/79697 Coyle, 1999, Gastroenterology, 116, a1198 Urso, 2002, Lancet, 359, 355, 10.1016/S0140-6736(02)07566-9 Marchesini, 2001, Lancet, 358, 893, 10.1016/S0140-6736(01)06042-1 Zhou, 2001, J Clin Invest, 108, 1167, 10.1172/JCI13505 Chiasson, 2002, Lancet, 359, 2072, 10.1016/S0140-6736(02)08905-5 Santomauro, 1999, Diabetes, 48, 1836, 10.2337/diabetes.48.9.1836 Nestler, 2000, J Pediatr Endocrinol, 13, 1295 Saibara, 1999, Lancet, 353, 1802, 10.1016/S0140-6736(05)75907-9 Basaranoglu, 1999, J Hepatol, 31, 384, 10.1016/S0168-8278(99)80243-8 Horlander, 2001, Gastroenterology, 120, a544, 10.1016/S0016-5085(08)82704-7 Nair, 2002, Hepatology, 36, 409a, 10.1053/jhep.2002.33713 Phillips, 2002, Ann Intern Med, 137, 581, 10.7326/0003-4819-137-7-200210010-00009 Mensenkamp, 2001, J Hepatol, 35, 816, 10.1016/S0168-8278(01)00249-5 Czaja, 1997, Liver Transplant Surg, 3, 185, 10.1002/lt.500030215 Molloy, 1997, Liver Transplant Surg, 3, 177, 10.1002/lt.500030212 Carson, 1997, Liver Transplant Surg, 3, 174, 10.1002/lt.500030211 Kim, 1996, Transplantation, 62, 1802, 10.1097/00007890-199612270-00021 Cassarino, 1998, Biochem Biophys Res Commun, 248, 168, 10.1006/bbrc.1998.8866 Cassarino, 2003, Hepatology, 37, 244, 10.1002/hep.510370203 Brunt, 1999, Am J Gastroenterol, 94, 2467, 10.1111/j.1572-0241.1999.01377.x Sozo, 2001, Gastroenterology, 120, a118, 10.1016/S0016-5085(08)80578-1 , , . Abnormal hydrogen breath test in patients with NASH [Abstract]. AASLD Syllabus Single Topic Conference Nonalcoholic Steatohepatitis, September 20-22, 2002. Atlanta, GA. Al-Osaimi, 2002, Hepatology, 36, 408a, 10.1016/S0168-8278(01)00281-1 Guillausseau, 2001, Ann Intern Med, 134, 721, 10.7326/0003-4819-134-9_Part_1-200105010-00008 Caldwell, 2002, Am J Gastroenterol, 97, 2058, 10.1111/j.1572-0241.2002.05922.x Diehl, 1988, Gastroenterology, 95, 1056, 10.1016/0016-5085(88)90183-7 Nagore, 1988, Liver, 8, 281, 10.1111/j.1600-0676.1988.tb01005.x Tumiel, 1994, Hepatology, 20, 409a Tajiri, 1997, J Clin Gastroenterol, 25, 538, 10.1097/00004836-199710000-00012 Bonkovsky, 1999, J Hepatol, 31, 421, 10.1016/S0168-8278(99)80032-4 George, 1998, Gastroenterology, 114, 311, 10.1016/S0016-5085(98)70482-2 Younossi, 1999, Hepatology, 30, 847, 10.1002/hep.510300407 Siegelman, 2001, Semin Liver Dis, 21, 71, 10.1055/s-2001-12930 Franzese, 1997, Dig Dis Sci, 42, 1428, 10.1023/A:1018850223495 Obinata, 1996, Adv Exp Med Biol, 403, 607, 10.1007/978-1-4899-0182-8_67 Day, 1998, [Editorial] Gastroenterology, 114, 842, 10.1016/S0016-5085(98)70599-2