Id2 represses E2A-mediated activation of IL-10 expression in T cells

Blood - Tập 123 - Trang 3420-3428 - 2014
Frederick Masson1,2, Margherita Ghisi3, Joanna R. Groom1,2, Axel Kallies1,2, Cyril Seillet1,2, Ricky W. Johnstone3,4, Stephen L. Nutt1,2, Gabrielle T. Belz1,2
1Division of Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia;
2Department of Medical Biology, University of Melbourne, Melbourne, Australia
3Peter MacCallum Cancer Centre, Melbourne, Australia; and
4Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia

Tóm tắt

Key Points

Loss of Id2 in T cells results in overexpression of IL-10 during influenza infection and GVHD and protects against GVHD immunopathology. Id2 represses the direct E2A-mediated activation of the Il10 locus in effector T cells.


Tài liệu tham khảo

Markey, 2008, Impact of cytokine gene polymorphisms on graft-vs-host disease., Tissue Antigens, 72, 507, 10.1111/j.1399-0039.2008.01139.x Lin, 2003, Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation., N Engl J Med, 349, 2201, 10.1056/NEJMoa022060 Lin, 2005, Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between IL-10 genotype of patient and IL-10 receptor beta genotype of donor., Blood, 106, 3995, 10.1182/blood-2004-11-4338 Sun, 2009, Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10., Nat Med, 15, 277, 10.1038/nm.1929 Perona-Wright, 2012, Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response., Proc Natl Acad Sci USA, 109, 18535, 10.1073/pnas.1119133109 Moore, 2001, Interleukin-10 and the interleukin-10 receptor., Annu Rev Immunol, 19, 683, 10.1146/annurev.immunol.19.1.683 Fahey, 2010, Opposing positive and negative regulation of T cell activity during viral persistence., Curr Opin Immunol, 22, 348, 10.1016/j.coi.2010.03.004 Tussiwand, 2012, Compensatory dendritic cell development mediated by BATF-IRF interactions., Nature, 490, 502, 10.1038/nature11531 Apetoh, 2010, The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27., Nat Immunol, 11, 854, 10.1038/ni.1912 Li, 2012, BATF-JUN is critical for IRF4-mediated transcription in T cells., Nature, 490, 543, 10.1038/nature11530 Motomura, 2011, The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells., Nat Immunol, 12, 450, 10.1038/ni.2020 Iwasaki, 2013, Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+ T cells., Eur J Immunol, 43, 1063, 10.1002/eji.201242942 Cretney, 2011, The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells., Nat Immunol, 12, 304, 10.1038/ni.2006 Sun, 2011, CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs., Nat Immunol, 12, 327, 10.1038/ni.1996 Lee, 2009, A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells., Mol Immunol, 46, 613, 10.1016/j.molimm.2008.07.037 Cannarile, 2006, Transcriptional regulator Id2 mediates CD8+ T cell immunity., Nat Immunol, 7, 1317, 10.1038/ni1403 Masson, 2013, Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation., J Immunol, 190, 4585, 10.4049/jimmunol.1300099 Knell, 2013, Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells., J Immunol, 190, 1501, 10.4049/jimmunol.1200750 Kee, 2009, E and ID proteins branch out., Nat Rev Immunol, 9, 175, 10.1038/nri2507 Seillet, 2013, CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3., Blood, 121, 1574, 10.1182/blood-2012-07-445650 Hogquist, 1994, T cell receptor antagonist peptides induce positive selection., Cell, 76, 17, 10.1016/0092-8674(94)90169-4 Hennet, 1995, T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination., Proc Natl Acad Sci USA, 92, 12070, 10.1073/pnas.92.26.12070 Kamanaka, 2006, Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse., Immunity, 25, 941, 10.1016/j.immuni.2006.09.013 Mittrücker, 1997, Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function., Science, 275, 540, 10.1126/science.275.5299.540 Belz, 2000, A previously unrecognized H-2D(b)-restricted peptide prominent in the primary influenza A virus-specific CD8(+) T-cell response is much less apparent following secondary challenge., J Virol, 74, 3486, 10.1128/JVI.74.8.3486-3493.2000 Mielke, 2013, TCF-1 controls ILC2 and NKp46+RORγt+ innate lymphocyte differentiation and protection in intestinal inflammation., J Immunol, 191, 4383, 10.4049/jimmunol.1301228 Spolski, 2009, IL-21 mediates suppressive effects via its induction of IL-10., J Immunol, 182, 2859, 10.4049/jimmunol.0802978 Saraiva, 2009, Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose., Immunity, 31, 209, 10.1016/j.immuni.2009.05.012 Stumhofer, 2007, Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10., Nat Immunol, 8, 1363, 10.1038/ni1537 D’Cruz, 2012, Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response., Eur J Immunol, 42, 2031, 10.1002/eji.201242497 Blazar, 1998, Interleukin-10 dose-dependent regulation of CD4+ and CD8+ T cell-mediated graft-versus-host disease., Transplantation, 66, 1220, 10.1097/00007890-199811150-00018 Blazar, 1995, Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts., Blood, 85, 842, 10.1182/blood.V85.3.842.bloodjournal853842 Mumm, 2011, IL-10 elicits IFNγ-dependent tumor immune surveillance., Cancer Cell, 20, 781, 10.1016/j.ccr.2011.11.003 O’Garra, 2008, Strategies for use of IL-10 or its antagonists in human disease., Immunol Rev, 223, 114, 10.1111/j.1600-065X.2008.00635.x van der Stoep, 2004, E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII)., Blood, 104, 2849, 10.1182/blood-2004-03-0790 Lazorchak, 2006, E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells., Mol Cell Biol, 26, 810, 10.1128/MCB.26.3.810-821.2006 Sun, 2011, Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus., PLoS Pathog, 7, e1002173, 10.1371/journal.ppat.1002173 Cui, 2011, An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells., Immunity, 35, 792, 10.1016/j.immuni.2011.09.017