Longitudinal grey-matter and glutamatergic losses in first-episode schizophrenia

British Journal of Psychiatry - Tập 191 Số 4 - Trang 325-334 - 2007
Jean Théberge1, Kate E. Williamson2, Naoko Aoyama3, Dick Drost1, Rahul Manchanda4, Ashok Malla5, Sarah Northcott4, Ravi S. Menon6, Richard W. J. Neufeld7, Nagalingam Rajakumar8, William Pavlosky9, Maria Densmore10, Betsy Schaefer11, Peter Williamson12
1Department of Diagnostic Imaging, St Joseph's Health Care, Lawson Health Research Institute, Department of Medical Biophysics and Department of Psychiatry, University of Western Ontario, London, Ontario
2Lawson Health Research Institute and Department of Psychiatry, University of Western Ontario, London, Ontario
3Lawson Health Research Institute and Department of Medical Biophysics, University of Western Ontario, London, Ontario
4Department of Psychiatry, University of Western Ontario, London, Ontario
5Department of Psychiatry, McGill University, Montreal, Quebec
6Departments of Medical Biophysics and Psychiatry, University of Western Ontario and Centre for Functional and Metabolic Mapping, Robarts Research Institute London Ontario
7Departments of Psychology and Psychiatry, University of Western Ontario
8Departments of Medical Biophysics Psychiatry and Anatomy and Cell Biology University of Western Ontario, London, Ontario
9Department of Diagnostic Imaging, St Joseph's Health Care, London, Ontario
10Lawson Health Research Institute and Department of Psychiatry, University of Western Ontario
11Department of Psychiatry, University of Western Ontario
12Lawson Health Research Institute and Departments of Psychiatry and Medical Biophysics, University of Western Ontario, London, Ontario, Canada

Tóm tắt

BackgroundProgressive volumetric changes in the brains of people with schizophrenia have been attributed to a number of factors.AimsTo determine whether glutamatergic changes in patients with schizophrenia correlated with grey-matter losses during the first years of illness.MethodLeft anterior cingulate and thalamic glutamatergic metabolite levels and grey-matter volumes were examined in 16 patients with first-episode schizophrenia before and after 10 months and 30 months of antipsychotic treatment and in 16 healthy participants on two occasions 30 months apart.ResultsHigher than normal glutamine levels were found in the anterior cingulate and thalamus of never-treated patients. Thalamic levels of glutamine were significantly reduced after 30 months. Limited grey-matter reductions were seen in patients at 10 months followed by widespread grey-matter loss at 30 months. Parietal and temporal lobe grey-matter loss was correlated with thalamic glutamine loss.ConclusionsElevated glutamine levels in never-treated patients followed by decreased thalamic glutamine and grey-matter loss in connected regions could indicate either neurodegeneration or a plastic response to reduced subcortical activity.

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British Journal of Psychiatry

Tập 191 Số 4

325-334

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