A common challenge in older adults: Classification, overlap, and therapy of depression and dementia

Alzheimer's & Dementia - Tập 13 - Trang 59-71 - 2017
Thomas Leyhe1, Charles F. Reynolds2, Tobias Melcher1, Christoph Linnemann1, Stefan Klöppel3, Kaj Blennow4, Henrik Zetterberg4,5, Bruno Dubois6, Simone Lista7,8, Harald Hampel6,8
1Center of Old Age Psychiatry, Psychiatric University Hospital, Basel, Switzerland
2Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
3Department of Psychiatry and Psychotherapy, Center for Geriatric Medicine and Gerontology, Department of Neurology, University Medical Center Freiburg, Freiburg, Germany
4Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
5University College London Institute of Neurology, London, UK
6Sorbonne Universités, Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) & Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France
7IHU-A-ICM—Paris Institute of Translational Neurosciences, Pitié-Salpêtrière University Hospital, Paris, France
8AXA Research Fund & UPMC Chair, Paris, France

Tóm tắt

AbstractLate‐life depression is frequently associated with cognitive impairment. Depressive symptoms are often associated with or even precede a dementia syndrome. Moreover, depressive disorders increase the risk of persistence for mild cognitive impairment and dementia. Here, we present both the current state of evidence and future perspectives regarding the integration and value of clinical assessments, neuropsychological, neurochemical, and neuroimaging biomarkers for the etiological classification of the dementia versus the depression syndrome and for the prognosis of depression relating to dementia risk. Finally, we summarize the existing evidence for both pharmacotherapy and psychotherapy of depression in demented patients. There is an urgent need for large‐scale collaborative research to elucidate the role and interplay of clinical and biological features in elderly individuals with depressive disorders who are at elevated risk for developing dementia. To overcome barriers for successful drug development, we propose the introduction of the precision medicine paradigm to this research field.

Tài liệu tham khảo

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Alzheimer's & Dementia

Tập 13

59-71

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