Weak Agonistic LPS Restores Intestinal Immune Homeostasis

Herfarth, 2005, Inflammatory bowel disease, Endoscopy, 37, 42, 10.1055/s-2004-826083 Jostins, 2012, Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease, Nature, 491, 119, 10.1038/nature11582 Abegunde, 2016, Environmental risk factors for inflammatory bowel diseases: Evidence based literature review, World J. Gastroenterol., 22, 6296, 10.3748/wjg.v22.i27.6296 Duboc, 2013, Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases, Gut, 62, 531, 10.1136/gutjnl-2012-302578 Peyrin-Biroulet, 2017, Systematic review of tumor necrosis factor antagonists in extraintestinal manifestations in inflammatory bowel disease, Clin. Gastroenterol. Hepatol., 15, 25, 10.1016/j.cgh.2016.06.025 Bragazzi, 2017, Public health awareness of autoimmune diseases after the death of a celebrity, Clin. Rheumatol., 36, 1911, 10.1007/s10067-016-3513-5 Gronbach, 2014, Endotoxicity of lipopolysaccharide as a determinant of T-cell-mediated colitis induction in mice, Gastroenterology, 146, 765, 10.1053/j.gastro.2013.11.033 d’Hennezel, 2017, Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling, mSystems, 2, e00046-17, 10.1128/mSystems.00046-17 Alexander, 2001, Bacterial lipopolysaccharides and innate immunity, J. Endotoxin Res., 7, 167 Steimle, 2016, Structure and function: Lipid A modifications in commensals and pathogens, Int. J. Med. Microbiol., 306, 290, 10.1016/j.ijmm.2016.03.001 Silipo, 2012, Structural characterization of two lipopolysaccharide O-antigens produced by the endofungal bacterium Burkholderia sp. HKI-402 (B4), Carbohydr. Res., 347, 95, 10.1016/j.carres.2011.10.038 Molinaro, 2015, Chemistry of lipid A: at the heart of innate immunity, Chemistry, 21, 500, 10.1002/chem.201403923 Park, 2009, The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex, Nature, 458, 1191, 10.1038/nature07830 Foster, 2007, Gene-specific control of inflammation by TLR-induced chromatin modifications, Nature, 447, 972, 10.1038/nature05836 Cavaillon, 2006, Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis, Crit. Care, 10, 233, 10.1186/cc5055 Biswas, 2009, Endotoxin tolerance: new mechanisms, molecules and clinical significance, Trends Immunol., 30, 475, 10.1016/j.it.2009.07.009 Wolk, 2003, Multiple mechanisms of reduced major histocompatibility complex class II expression in endotoxin tolerance, J. Biol. Chem., 278, 18030, 10.1074/jbc.M207714200 Wolk, 2000, Impaired antigen presentation by human monocytes during endotoxin tolerance, Blood, 96, 218, 10.1182/blood.V96.1.218 Steimle, 2016, Molecular Mechanisms of Induction of Tolerant and Tolerogenic Intestinal Dendritic Cells in Mice, J. Immunol. Res., 2016, 1958650 Waidmann, 2003, Bacteroides vulgatus protects against Escherichia coli-induced colitis in gnotobiotic interleukin-2-deficient mice, Gastroenterology, 125, 162, 10.1016/S0016-5085(03)00672-3 Müller, 2008, Intestinal colonization of IL-2 deficient mice with non-colitogenic B. vulgatus prevents DC maturation and T-cell polarization, PLoS ONE, 3, e2376, 10.1371/journal.pone.0002376 Steimle, 2016, Symbiotic gut commensal bacteria act as host cathepsin S activity regulators, J. Autoimmun., 75, 82, 10.1016/j.jaut.2016.07.009 Coyne, 2014, Evidence of extensive DNA transfer between bacteroidales species within the human gut, MBio, 5, e01305, 10.1128/mBio.01305-14 Mazmanian, 2008, A microbial symbiosis factor prevents intestinal inflammatory disease, Nature, 453, 620, 10.1038/nature07008 Morrissey, 1993, CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells, J. Exp. Med., 178, 237, 10.1084/jem.178.1.237 Rigoni, 2016, RAGs and BUGS: An alliance for autoimmunity, Gut Microbes, 7, 503, 10.1080/19490976.2016.1228517 Kiesler, 2015, Experimental Models of Inflammatory Bowel Diseases, Cell. Mol. Gastroenterol. Hepatol., 1, 154, 10.1016/j.jcmgh.2015.01.006 Pellegrino, 2005, Inflammation and infection: imaging properties of 18F-FDG-labeled white blood cells versus 18F-FDG, J. Nucl. Med., 46, 1522 Kamada, 2013, Control of pathogens and pathobionts by the gut microbiota, Nat. Immunol., 14, 685, 10.1038/ni.2608 Chassaing, 2011, The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases, Gastroenterology, 140, 1720, 10.1053/j.gastro.2011.01.054 Frick, 2006, Colitogenic and non-colitogenic commensal bacteria differentially trigger DC maturation and Th cell polarization: an important role for IL-6, Eur. J. Immunol., 36, 1537, 10.1002/eji.200635840 Jacobson, 2018, The Biosynthesis of Lipooligosaccharide from Bacteroides thetaiotaomicron, MBio, 9, 10.1128/mBio.02289-17 Vatanen, 2016, Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans, Cell, 165, 1551, 10.1016/j.cell.2016.05.056 Weintraub, 1989, Structural characterization of the lipid A component of Bacteroides fragilis strain NCTC 9343 lipopolysaccharide, Eur. J. Biochem., 183, 425, 10.1111/j.1432-1033.1989.tb14945.x Matsunaga, 2011, TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules, Mol. Pharmacol., 79, 34, 10.1124/mol.110.068064 Ii, 2006, A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling, Mol. Pharmacol., 69, 1288, 10.1124/mol.105.019695 Roebuck, 1999, Regulation of interleukin-8 gene expression, J. Interferon Cytokine Res., 19, 429, 10.1089/107999099313866 Ahmed, 2014, Integrin-linked kinase modulates lipopolysaccharide- and Helicobacter pylori-induced nuclear factor κB-activated tumor necrosis factor-α production via regulation of p65 serine 536 phosphorylation, J. Biol. Chem., 289, 27776, 10.1074/jbc.M114.574541 Chen, 2005, NF-kappaB RelA phosphorylation regulates RelA acetylation, Mol. Cell. Biol., 25, 7966, 10.1128/MCB.25.18.7966-7975.2005 Bazewicz, 2019, Aldehyde dehydrogenase in regulatory T-cell development, immunity and cancer, Immunology, 156, 47, 10.1111/imm.13016 Agace, 2012, How vitamin A metabolizing dendritic cells are generated in the gut mucosa, Trends Immunol., 33, 42, 10.1016/j.it.2011.10.001 Hall, 2011, The role of retinoic acid in tolerance and immunity, Immunity, 35, 13, 10.1016/j.immuni.2011.07.002 Chavarría-Velázquez, 2018, TLR2 activation induced by H. pylori LPS promotes the differential expression of claudin-4, -6, -7 and -9 via either STAT3 and ERK1/2 in AGS cells, Immunobiology, 223, 38, 10.1016/j.imbio.2017.10.016 Nativel, 2017, Porphyromonas gingivalis lipopolysaccharides act exclusively through TLR4 with a resilience between mouse and human, Sci. Rep., 7, 15789, 10.1038/s41598-017-16190-y Hashimoto, 2017, TLR2-stimulating contaminants in glycoconjugate fractions prepared from Bacteroides fragilis, Innate Immun., 23, 449, 10.1177/1753425917714313 Zughaier, 2011, Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2, J. Leukoc. Biol., 89, 469, 10.1189/jlb.0610369 Graveline, 2007, TLR2-dependent recognition of Streptococcus suis is modulated by the presence of capsular polysaccharide which modifies macrophage responsiveness, Int. Immunol., 19, 375, 10.1093/intimm/dxm003 Wang, 2014, An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling, Nat. Commun., 5, 4432, 10.1038/ncomms5432 Hirschfeld, 1999, Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2, J. Immunol., 163, 2382, 10.4049/jimmunol.163.5.2382 Lee, 2002, Two lipoproteins extracted from Escherichia coli K-12 LCD25 lipopolysaccharide are the major components responsible for Toll-like receptor 2-mediated signaling, J. Immunol., 168, 4012, 10.4049/jimmunol.168.8.4012 Fisette, 2003, The Lip lipoprotein from Neisseria gonorrhoeae stimulates cytokine release and NF-kappaB activation in epithelial cells in a Toll-like receptor 2-dependent manner, J. Biol. Chem., 278, 46252, 10.1074/jbc.M306587200 Bachmanov, 2002, Food intake, water intake, and drinking spout side preference of 28 mouse strains, Behav. Genet., 32, 435, 10.1023/A:1020884312053 Iwasaki, 2015, Control of adaptive immunity by the innate immune system, Nat. Immunol., 16, 343, 10.1038/ni.3123 Tan, 2015, Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria, Immunity, 43, 909, 10.1016/j.immuni.2015.10.008 Kumari, 2013, Fluctuations in butyrate-producing bacteria in ulcerative colitis patients of North India, World J. Gastroenterol., 19, 3404, 10.3748/wjg.v19.i22.3404 Dasgupta, 2014, Plasmacytoid dendritic cells mediate anti-inflammatory responses to a gut commensal molecule via both innate and adaptive mechanisms, Cell Host Microbe, 15, 413, 10.1016/j.chom.2014.03.006 Ochoa-Repáraz, 2010, A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease, Mucosal Immunol., 3, 487, 10.1038/mi.2010.29 Sun, 2017, Lactobacillus paracasei modulates LPS-induced inflammatory cytokine release by monocyte-macrophages via the up-regulation of negative regulators of NF-kappaB signaling in a TLR2-dependent manner, Cytokine, 92, 1, 10.1016/j.cyto.2017.01.003 Brandenburg, 1993, Influence of the supramolecular structure of free lipid A on its biological activity, Eur. J. Biochem., 218, 555, 10.1111/j.1432-1033.1993.tb18409.x Seydel, 2000, Intrinsic conformation of lipid A is responsible for agonistic and antagonistic activity, Eur. J. Biochem., 267, 3032, 10.1046/j.1432-1033.2000.01326.x Rietschel, 1994, Bacterial endotoxin: molecular relationships of structure to activity and function, FASEB J., 8, 217, 10.1096/fasebj.8.2.8119492 Hamacher, 1986, Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution, J. Nucl. Med., 27, 235 Mannheim, 2012, Quantification accuracy and partial volume effect in dependence of the attenuation correction of a state-of-the-art small animal PET scanner, Phys. Med. Biol., 57, 3981, 10.1088/0031-9155/57/12/3981 Lange, 2016, Extensive Mobilome-Driven Genome Diversification in Mouse Gut-Associated Bacteroides vulgatus mpk, Genome Biol. Evol., 8, 1197, 10.1093/gbe/evw070 Westphal, 1965, Bacterial lipopolysaccharides: extraction with phenol-water and further applications of procedure, Carbohydr. Chem., 5, 83 Lutz, 1999, An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow, J. Immunol. Methods, 223, 77, 10.1016/S0022-1759(98)00204-X Jeon, 2012, Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon, PLoS Pathog., 8, e1002714, 10.1371/journal.ppat.1002714 Rakoff-Nahoum, 2004, Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis, Cell, 118, 229, 10.1016/j.cell.2004.07.002 Chow, 2010, A pathobiont of the microbiota balances host colonization and intestinal inflammation, Cell Host Microbe, 7, 265, 10.1016/j.chom.2010.03.004