Dementia incidence continues to increase with age in the oldest old: The 90+ study

Annals of Neurology - Tập 67 Số 1 - Trang 114-121 - 2010
María M. Corrada1,2, Ron Brookmeyer3, Annlia Paganini‐Hill1,4, Daniel J. Berlau1,2, Claudia H. Kawas5,1,2
1Department of Neurology, University of California, Irvine, CA
2Institute for Memory Impairment and Neurological Disorders, University of California, Irvine, CA
3Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
4Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA
5Department of Neurobiology and Behavior, University of California, Irvine, CA

Tóm tắt

AbstractObjectiveThe oldest old are the fastest growing segment of the US population, and accurate estimates of dementia incidence in this group are crucial for healthcare planning. Although dementia incidence doubles every 5 years from ages 65 to 90 years, it is unknown if this exponential increase continues past age 90 years. Here, we estimate age‐ and sex‐specific incidence rates of all‐cause dementia in people aged 90 years and older, including estimates for centenarians.MethodsParticipants are from The 90+ Study, a population‐based longitudinal study of aging and dementia. Three hundred thirty nondemented participants aged 90 years and older at baseline were followed between January 2003 and December 2007. Age‐ and sex‐specific incidence rates of all‐cause dementia were estimated by person‐years analysis.ResultsThe overall incidence rate of all‐cause dementia was 18.2% (95% confidence interval [CI], 15.3–21.5) per year and was similar for men and women (risk ratio, 0.94; 95% CI, 0.65–1.37). Rates increased exponentially with age from 12.7% per year in the 90–94‐year age group, to 21.2% per year in the 95–99‐year age group, to 40.7% per year in the 100+‐year age group. The doubling time based on a Poisson regression was 5.5 years.InterpretationIncidence of all‐cause dementia is very high in people aged 90 years and older and continues to increase exponentially with age in both men and women. Projections of the number of people with dementia should incorporate this continuing increase of dementia incidence after age 90 years. Our results foretell the growing public health burden of dementia in an increasingly aging population. ANN NEUROL 2010;67:114–121

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Annals of Neurology

Tập 67 Số 1

114-121

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