Gut microbiota in older subjects: variation, health consequences and dietary intervention prospects

Proceedings of the Nutrition Society - Tập 73 Số 4 - Trang 441-451 - 2014
Eibhlís M. O’Connor1, Eileen O’Herlihy2, Paul W. O’Toole3,2
1Department of Life Sciences, University of Limerick, Ireland
2School of Microbiology, University College Cork, Ireland
3Alimentary Pharmabiotic Centre, University College Cork, Ireland

Tóm tắt

Alterations in intestinal microbiota composition and function have been linked to conditions including functional gastrointestinal disorders, obesity and diabetes. The gut microbiome encodes metabolic capability in excess of that encoded by the human genome, and bacterially produced enzymes are important for releasing nutrients from complex dietary ingredients. Previous culture-based studies had indicated that the gut microbiota of older people was different from that of younger adults, but the detailed findings were contradictory. Small-scale studies had also shown that the microbiota composition could be altered by dietary intervention or supplementation. We showed that the core microbiota and aggregate composition in 161 seniors was distinct from that of younger persons. To further investigate the reasons for this variation, we analysed the microbiota composition of 178 elderly subjects for whom the dietary intake data were available. The data revealed distinct microbiota composition groups, which overlapped with distinct dietary patterns that were governed by where people lived: at home, in rehabilitation or in long-term residential care. These diet–microbiota separations correlated with cluster analysis of NMR-derived faecal metabolites and shotgun metagenomic data. Major separations in the microbiota correlated with selected clinical measurements. It should thus be possible to programme the microbiota to enrich bacterial species and activities that promote healthier ageing. A number of other studies have investigated the effect of certain dietary components and their ability to modulate the microbiota composition to promote health. This review will discuss dietary interventions conducted thus far, especially those in elderly populations and highlight their impact on the intestinal microbiota.

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Tài liệu tham khảo

Gibson, 1995, Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics, J Nutr, 125, 1401, 10.1093/jn/125.6.1401

10.1038/nature11450

10.1073/pnas.0605374104

10.1111/j.1749-6632.2000.tb06651.x

10.1038/nrmicro2859

10.1038/nature09944

10.1016/0006-291X(85)91878-9

10.1016/S0271-5317(01)00354-2

10.1073/pnas.1005963107

10.1371/journal.pone.0036957

10.2337/db11-1019

10.1126/science.1237439

10.1371/journal.pbio.0060280

10.1128/AEM.70.10.6113-6122.2004

10.1079/BJN19900150

10.1038/nature11552

10.1371/journal.pone.0025200

10.2337/db06-1491

10.1038/ncomms2852

10.1038/nature12503

10.1101/gr.126516.111

10.1073/pnas.0804812105

10.1128/AEM.70.6.3575-3581.2004

10.4161/gmic.22157

10.4161/gmic.19411

10.1371/journal.pbio.0050177

10.1038/nature12480

10.1016/j.tem.2006.11.006

10.3945/jn.112.166322

10.1016/j.anaerobe.2012.04.014

10.1038/oby.2009.167

Macfarlane, 2008, Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics, J Appl Microbiol, 104, 305

10.1111/j.1758-2229.2009.00116.x

10.1017/S0007114507730751

10.1038/nature12820

10.1126/science.1110591

10.1126/science.1229000

10.1126/scitranslmed.3000322

10.1152/physrev.00045.2009

10.1128/AEM.68.1.219-226.2002

10.3945/ajcn.110.010132

10.1016/j.idairyj.2009.11.010

10.1073/pnas.1306070110

10.1016/j.tim.2010.03.008

10.1038/nature07540

10.1101/gr.126573.111

10.3322/caac.20107

10.1016/j.chom.2013.07.007

10.1210/er.2005-0009

10.1371/journal.pone.0015046

10.1111/j.1753-4887.2012.00505.x

10.1017/S0029665110000091

10.1186/1475-2859-10-S1-S10

10.1111/j.1365-2036.2008.03911.x

10.1038/nature11582

10.1016/j.copbio.2012.08.005

10.1038/nature08821

10.1038/ijo.2008.155

Salminen, 2012, Probiotics and prebiotics: health claim substantiation, Microb Ecol Health Dis, 23

10.3945/jn.112.166132

10.1111/j.1751-7915.2008.00064.x

10.2337/db06-0812

10.1016/j.cell.2006.02.017

10.1126/science.1224820

10.1038/nature11400

10.1136/gut.2005.073817

10.1016/j.chom.2008.02.015

10.1371/journal.pone.0035240

10.1038/ismej.2007.3

10.1053/j.gastro.2012.01.034

Zoetendal, 1998, Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria, Appl Environ Microbiol, 64, 3854, 10.1128/AEM.64.10.3854-3859.1998

10.1111/j.1365-2672.2007.03400.x

10.1016/j.phrs.2009.11.001

10.1159/000354907

10.1038/nature05414

10.1126/science.1241214

10.1152/ajpgi.00154.2011

10.1053/j.gastro.2012.06.031

10.1099/0022-1317-51-5-448

10.5582/bst.2011.v5.4.139

10.1038/msb.2010.46

10.1038/nature11234

10.1038/nrgastro.2012.152

10.1016/j.bpg.2003.10.008

10.1111/j.1651-2227.2008.01060.x

10.1073/pnas.0706625104

10.4291/wjgp.v2.i6.138

10.1017/S0007114511004697

10.1038/nature12198

10.1073/pnas.1000097107

10.1017/S0007114510003363

10.1136/gutjnl-2012-302167

10.1017/S0007114508019880

10.1097/MCO.0b013e3283638eb3

10.3945/jn.112.158766

Vulevic, 2008, Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers, Am J Clin Nutr, 88, 1438, 10.3945/ajcn.2008.26242

10.1186/1475-2891-6-42

10.3389/fmicb.2011.00149

10.1371/journal.pone.0084689

10.1017/S0007114510001303

10.1016/j.numecd.2010.09.007

10.1038/nature11053

10.1371/journal.pone.0020944

10.1038/nature11319

10.3945/jn.112.169672

10.1073/pnas.1002601107

10.1111/j.1462-2920.2009.01900.x

10.1371/journal.pone.0010667

10.1007/s11357-011-9217-5

10.1128/AEM.72.2.1027-1033.2006

10.1038/nrgastro.2012.44

10.1093/ajcn/65.5.1397

10.1128/AEM.71.10.6438-6442.2005

10.1371/journal.pone.0034242

10.1038/4441022a

10.1038/nature12506

10.1126/science.1208344

10.1038/nm.2015

10.4161/cbt.5.10.3296

10.1038/ismej.2010.118

10.1007/978-3-642-30144-5_88

10.1017/S0007114508055608

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Proceedings of the Nutrition Society

Tập 73 Số 4

441-451

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