Bench-to-bedside review: Bacterial pneumonia with influenza - pathogenesis and clinical implications

Critical Care - Tập 14 - Trang 1-8 - 2010
Koenraad F van der Sluijs1, Tom van der Poll2, René Lutter1, Nicole P Juffermans3, Marcus J Schultz3
1Departments of Pulmonology and Experimental Immunology, Academic Medical Center, Amsterdam, Netherlands
2Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, Netherlands
3Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, Amsterdam, Netherlands

Tóm tắt

Seasonal and pandemic influenza are frequently complicated by bacterial infections, causing additional hospitalization and mortality. Secondary bacterial respiratory infection can be subdivided into combined viral/bacterial pneumonia and post-influenza pneumonia, which differ in their pathogenesis. During combined viral/bacterial infection, the virus, the bacterium and the host interact with each other. Post-influenza pneumonia may, at least in part, be due to resolution of inflammation caused by the primary viral infection. These mechanisms restore tissue homeostasis but greatly impair the host response against unrelated bacterial pathogens. In this review we summarize the underlying mechanisms leading to combined viral/bacterial infection or post-influenza pneumonia and highlight important considerations for effective treatment of bacterial pneumonia during and shortly after influenza.

Tài liệu tham khảo

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