Inflammation and insulin resistance

FEBS Letters - Tập 582 - Trang 97-105 - 2008
Carl de Luca1, Jerrold M. Olefsky1
1University of California at San Diego, Department of Medicine (0673), 225 Stein Clinical Research Building, 9500 Gilman Drive, La Jolla, CA 92093, USA

Tóm tắt

Obesity‐induced chronic inflammation is a key component in the pathogenesis of insulin resistance and the Metabolic syndrome. In this review, we focus on the interconnection between obesity, inflammation and insulin resistance. Pro‐inflammatory cytokines can cause insulin resistance in adipose tissue, skeletal muscle and liver by inhibiting insulin signal transduction. The sources of cytokines in insulin resistant states are the insulin target tissue themselves, primarily fat and liver, but to a larger extent the activated tissue resident macrophages. While the initiating factors of this inflammatory response remain to be fully determined, chronic inflammation in these tissues could cause localized insulin resistance via autocrine/paracrine cytokine signaling and systemic insulin resistance via endocrine cytokine signaling all of which contribute to the abnormal metabolic state.

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FEBS Letters

Tập 582

97-105

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