MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors

Blood - Tập 125 - Trang 1302-1313 - 2015
Li-Sheng Wang1,2, Ling Li1, Liang Li1, Su Chu1, Keh-Dong Shiang3, Min Li3, Hui-Yan Sun2, Jun Xu2, Feng-Jun Xiao2, Guihua Sun4, John J. Rossi4, YinWei Ho1, Ravi Bhatia1
1Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope National Medical Center, Duarte, CA
2Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China; and
3Department of Information Sciences, Duarte, CA
4Department of Molecular and Cellular Biology, City of Hope National Medical Center, Duarte, CA

Tóm tắt

Key Points miR-486-5p is expressed in megakaryocyte-erythroid progenitors and regulates growth and survival by regulating FOXO1 and AKT. miR-486-5p is overexpressed in CML progenitors and enhances their growth, survival, and response to tyrosine kinase inhibitors.

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