Genome-wide DNA demethylation in mammals

Genome Biology - Tập 11 - Trang 1-4 - 2010
Lionel A Sanz1, Satya K Kota1, Robert Feil1
1Institute of Molecular Genetics, CNRS UMR-5535 and University of Montpellier, Montpellier, France

Tóm tắt

The cytidine deaminase AID and elongator-complex proteins contribute to the extensive removal of DNA methylation in mammalian primordial germ cells and in the paternal pronucleus of the zygote.

Tài liệu tham khảo

Sasaki H, Matsui Y: Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat Rev Genet. 2008, 9: 129-140. 10.1038/nrg2295. Popp C, Dean W, Feng S, Cokus SJ, Andrews S, Pellegrini M, Jacobsen SE, Reik W: Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature. 2010, 463: 1101-1105. 10.1038/nature08829. Bhutani N, Brady JJ, Damian M, Sacco A, Corbel SY, Blau HM: Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature. 2010, 463: 1042-1047. 10.1038/nature08752. Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y: A role for the elongator complex in zygotic paternal genome demethylation. Nature. 2010, 463: 554-558. 10.1038/nature08732. Gehring M, Huh JH, Hsieh TF, Penterman J, Choi Y, Harada JJ, Goldberg RB, Fisher RL: DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele specific demethylation. Cell. 2006, 124: 495-506. 10.1016/j.cell.2005.12.034. Morgan HD, Dean W, Coker HA, Reik W, Petersen-Mahrt SK: Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming. J Biol Chem. 2004, 279: 52353-52360. 10.1074/jbc.M407695200. Svejstrup JQ: Elongator complex: how many roles does it play?. Curr Opin Cell Biol. 2007, 19: 331-336. 10.1016/j.ceb.2007.04.005. Rai K, Huggins IJ, James SR, Karpf AR, Jones DA, Cairns BR: DNA demethylation in Zebrafish involves the coupling of a deaminase, a glycosylase, and Gadd45. Cell. 2008, 135: 1201-1212. 10.1016/j.cell.2008.11.042. Hendrich B, Hardeland U, Ng HH, Jiricny J, Bird A: The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites. Nature. 1999, 401: 301-304. 10.1038/45843. Santos F, Peters AH, Otte AP, Reik W, Dean W: Dynamic chromatin modifications characterise the first cell cycle in mouse embryos. Dev Biol. 2005, 280: 225-236. 10.1016/j.ydbio.2005.01.025. Hajkova P, Ancelin K, Waldmann T, Lacoste N, Lange UC, Cesari F, Lee C, Almouzni G, Schneider R, Surani MA: Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature. 2008, 452: 877-881. 10.1038/nature06714.