Deciphering the epidemic synergy of herpes simplex virus type 2 (HSV-2) on human immunodeficiency virus type 1 (HIV-1) infection among women in sub-Saharan Africa

Musie Ghebremichael1, Desale Habtzgi2, Elijah Paintsil3
1Harvard Medical School and Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA
2Department of Statistics, University of Akron, Akron, Ohio, USA
3Departments of Pediatrics and Pharmacology, Yale School of Medicine, New Haven, Connecticut, USA

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Looker KJ, Garnett GP, Schmid GP: An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bull World Health Organ. 2008, 86 (10): 805-812. 10.2471/BLT.07.046128. A.

Gwanzura L, McFarland W, Alexander D, Burke RL, Katzenstein D: Association between human immunodeficiency virus and herpes simplex virus type 2 seropositivity among male factory workers in Zimbabwe. J Infect Dis. 1998, 177 (2): 481-484. 10.1086/517381.

Reynolds SJ, Risbud AR, Shepherd ME, Zenilman JM, Brookmeyer RS, Paranjape RS, Divekar AD, Gangakhedkar RR, Ghate MV, Bollinger RC, et al: Recent herpes simplex virus type 2 infection and the risk of human immunodeficiency virus type 1 acquisition in India. J Infect Dis. 2003, 187 (10): 1513-1521. 10.1086/368357.

Todd J, Grosskurth H, Changalucha J, Obasi A, Mosha F, Balira R, Orroth K, Hugonnet S, Pujades M, Ross D, et al: Risk factors influencing HIV infection incidence in a rural African population: a nested case–control study. J Infect Dis. 2006, 193 (3): 458-466. 10.1086/499313.

Glynn JR, Biraro S, Weiss HA: Herpes simplex virus type 2: a key role in HIV incidence. AIDS. 2009, 23 (12): 1595-1598. 10.1097/QAD.0b013e32832e15e8.

Mbopi Keou FX, Gresenguet G, Mayaud P, Weiss HA, Gopal R, Brown DW, Hayes RJ, Mabey DC, Belec L: Genital herpes simplex virus type 2 shedding is increased in HIV-infected women in Africa. AIDS (London, England). 1999, 13 (4)): 536-537.

Schacker T, Zeh J, Hu H, Shaughnessy M, Corey L: Changes in plasma human immunodeficiency virus type 1 RNA associated with herpes simplex virus reactivation and suppression. J Infect Dis. 2002, 186 (12): 1718-1725. 10.1086/345771.

Corey L, Wald A, Celum CL, Quinn TC: The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics. J Acquir Immune Defic Syndr. 2004, 35 (5): 435-445. 10.1097/00126334-200404150-00001.

Johnson RE, Nahmias AJ, Magder LS, Lee FK, Brooks CA, Snowden CB: A seroepidemiologic survey of the prevalence of herpes simplex virus type 2 infection in the United States. N Engl J Med. 1989, 321 (1): 7-12. 10.1056/NEJM198907063210102.

Seroprevalence of herpes simplex virus type 2 among persons aged 14–49 years--United States. MMWR Morb Mortal Wkly Rep. 2005–2008, 59 (15): 456-459.

Abu-Raddad LJ, Magaret AS, Celum C, Wald A, Longini IM, Self SG, Corey L: Genital herpes has played a more important role than any other sexually transmitted infection in driving HIV prevalence in Africa. PLoS One. 2008, 3 (5): e2230-10.1371/journal.pone.0002230.

Celum C, Levine R, Weaver M, Wald A: Genital herpes and human immunodeficiency virus: double trouble. Bull World Health Organ. 2004, 82 (6): 447-453.

Wald A, Corey L: How does herpes simplex virus type 2 influence human immunodeficiency virus infection and pathogenesis?. J Infect Dis. 2003, 187 (10): 1509-1512. 10.1086/374976.

Celum C, Wald A, Lingappa JR, Magaret AS, Wang RS, Mugo N, Mujugira A, Baeten JM, Mullins JI, Hughes JP, et al: Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. N Engl J Med. 2010, 362 (5): 427-439. 10.1056/NEJMoa0904849.

Wawer MJ, Gray RH, Sewankambo NK, Serwadda D, Li X, Laeyendecker O, Kiwanuka N, Kigozi G, Kiddugavu M, Lutalo T, et al: Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda. J Infect Dis. 2005, 191 (9): 1403-1409. 10.1086/429411.

Mbopi-Keou FX, Legoff J, Gresenguet G, Si-Mohamed A, Matta M, Mayaud P, Andreoletti L, Malkin JE, Weiss H, Brown D, et al: Genital shedding of herpes simplex virus-2 DNA and HIV-1 RNA and proviral DNA in HIV-1- and herpes simplex virus-2-coinfected African women. J Acquir Immune Defic Syndr. 2003, 33 (2): 121-124. 10.1097/00126334-200306010-00001.

Ouedraogo A, Nagot N, Vergne L, Konate I, Weiss HA, Defer MC, Foulongne V, Sanon A, Andonaba JB, Segondy M, et al: Impact of suppressive herpes therapy on genital HIV-1 RNA among women taking antiretroviral therapy: a randomized controlled trial. AIDS. 2006, 20 (18): 2305-2313. 10.1097/QAD.0b013e328010238d.

Zuckerman RA, Lucchetti A, Whittington WL, Sanchez J, Coombs RW, Zuniga R, Magaret AS, Wald A, Corey L, Celum C: Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial. J Infect Dis. 2007, 196 (10): 1500-1508. 10.1086/522523.

Tanton C, Weiss HA, Rusizoka M, Legoff J, Changalucha J, Baisley K, Mugeye K, Everett D, Belec L, Clayton TC, et al: Long-term impact of acyclovir suppressive therapy on genital and plasma HIV RNA in Tanzanian women: a randomized controlled trial. J Infect Dis. 2010, 201 (9): 1285-1297. 10.1086/651696.

Ludema C, Cole SR, Poole C, Chu H, Eron JJ: Meta-analysis of randomized trials on the association of prophylactic acyclovir and HIV-1 viral load in individuals coinfected with herpes simplex virus-2. AIDS. 2011, 25 (10): 1265-1269. 10.1097/QAD.0b013e328347fa37.

Lisco A, Vanpouille C, Tchesnokov EP, Grivel JC, Biancotto A, Brichacek B, Elliott J, Fromentin E, Shattock R, Anton P, et al: Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues. Cell Host Microbe. 2008, 4 (3): 260-270. 10.1016/j.chom.2008.07.008.

Lisco A, Vanpouille C, Margolis L: A missed point in deciphering the viral synergy between herpes simplex virus and HIV. Lancet Infect Dis. 2009, 9 (9): 522-523. 10.1016/S1473-3099(09)70209-9.

Nilsen A, Mwakagile D, Marsden H, Langeland N, Matre R, Haarr L: Prevalence of, and risk factors for, HSV-2 antibodies in sexually transmitted disease patients, healthy pregnant females, blood donors and medical students in Tanzania and Norway. Epidemiol Infect. 2005, 133 (5): 915-925. 10.1017/S095026880500395X.

Ghebremichael M, Larsen U, Paintsil E: Association of age at first sex with HIV-1, HSV-2, and other sexual transmitted infections among women in northern Tanzania. Sex Transm Dis. 2009, 36 (9): 570-576. 10.1097/OLQ.0b013e3181a866b8.

Rabe-Hesketh S, Skrondal A: Classical latent variable models for medical research. Stat Methods Med Res. 2008, 17 (1): 5-32.

Schabenberger O: Growing up fast: SAS 9.2 enhancements to the GLIMMIX procedure. 2007, Orlando, FL: SAS Global Forum

Wald A, Link K: Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis. J Infect Dis. 2002, 185 (1): 45-52. 10.1086/338231.

Freeman EE, Weiss HA, Glynn JR, Cross PL, Whitworth JA, Hayes RJ: Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS. 2006, 20 (1): 73-83. 10.1097/01.aids.0000198081.09337.a7.

Brown JM, Wald A, Hubbard A, Rungruengthanakit K, Chipato T, Rugpao S, Mmiro F, Celentano DD, Salata RS, Morrison CS, et al: Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe. AIDS. 2007, 21 (12): 1515-1523. 10.1097/QAD.0b013e3282004929.

del Mar Pujades Rodriguez M, Obasi A, Mosha F, Todd J, Brown D, Changalucha J, Mabey D, Ross D, Grosskurth H, Hayes R: Herpes simplex virus type 2 infection increases HIV incidence: a prospective study in rural Tanzania. AIDS. 2002, 16 (3): 451-462. 10.1097/00002030-200202150-00018.

Kapiga SH, Bang H, Spiegelman D, Msamanga GI, Coley J, Hunter DJ, Fawzi WW: Correlates of plasma HIV-1 RNA viral load among HIV-1-seropositive women in Dar es Salaam, Tanzania. J Acquir Immune Defic Syndr. 2002, 30 (3): 316-323.

Cunningham AL, Turner RR, Miller AC, Para MF, Merigan TC: Evolution of recurrent herpes simplex lesions, An immunohistologic study. J Clin Invest. 1985, 75 (1): 226-233. 10.1172/JCI111678.

Koelle DM, Abbo H, Peck A, Ziegweid K, Corey L: Direct recovery of herpes simplex virus (HSV)-specific T lymphocyte clones from recurrent genital HSV-2 lesions. J Infect Dis. 1994, 169 (5): 956-961. 10.1093/infdis/169.5.956.

Margolis DM, Rabson AB, Straus SE, Ostrove JM: Transactivation of the HIV-1 LTR by HSV-1 immediate-early genes. Virology. 1992, 186 (2): 788-791. 10.1016/0042-6822(92)90048-T.

Ades AE, Peckham CS, Dale GE, Best JM, Jeansson S: Prevalence of antibodies to herpes simplex virus types 1 and 2 in pregnant women, and estimated rates of infection. J Epidemiol Community Health. 1989, 43 (1): 53-60. 10.1136/jech.43.1.53.