Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation
Tóm tắt
The association between basal cortisol, dehydroepiandrosterone (DHEA), its sulphate (DHEAS) and major depression was investigated in 8- to 16-year-olds. Eighty-two subjects with major depression, 25 non-depressed psychiatric cases and 40 community controls were systematically assessed for current mental state and hormone levels at 08.00, 12.00 and 20.00 h, assayed from salivary samples collected over a 48 h period. The average mean of the two time points was compared between the three groups. Evening cortisol hypersecretion and morning DHEA hyposecretion were significantly, and independently, associated with major depression. High evening cortisol (> 0·594 ng/ml) and low morning DHEA (< 0·200 ng/ml) identified subgroups of depressives with different types of adrenal hormone dysregulation. The association between high evening cortisol or low morning DHEA and MDD was not affected by either age or gender.
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Tài liệu tham khảo
Kutcher, 1989, Parameters of adolescent depression, Psychiatric Clinics of North America, 12, 895, 10.1016/S0193-953X(18)30403-9
1987, Diagnostic and Statistical Manual of Mental Disorders
Aitkin, 1989, Statistical Modelling in GLIM
Osran, 1993, Adrenal androgens and cortisol in major depression, American Journal of Psychiatry, 150, 806, 10.1176/ajp.150.5.806
Akina, 1992, The incidence on non-classical 21-hydroxylase deficiency in hirsute adolescent girls, Gynecological Endocrinology, 6, 99, 10.3109/09513599209046392
Walker, 1982, Immunoassay of Steroids in Saliva, 308
Guazzo E. , Kirkpatrick P. J. , Goodyer I. M. , Shiers H. M. & Herbert J. (1995). Cortisol, dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) in the cerebrospinal fluid of man: relation to blood levels and the effects of age. Journal of Clinical Endocrinology and Metabolism (in the press).
Reynolds, 1983, National normative and reliability data for the revised children's manifest anxiety scale, School Psychology Review, 12, 324, 10.1080/02796015.1983.12085047
Goodyer, 1991, Life Experiences, Development and Child Psychopathology
Puig-Antich, 1989, Cortisol secretion in prepubertal children with major depressive disorder. Episode and recovery, Archives of General Psychiatry, 46, 801, 10.1001/archpsyc.1989.01810090043008
Spratt, 1993, Differential changes in serum concentrations of androgens and estrogens (in relation with cortisol) in postmenopausal women with acute illness, Journal of Clinical Endocrinology and Metabolism, 76, 1542
Goodyer, 1995, The Depressed Child and Adolescent: Developmental and Clinical Perspectives
Kolvin, 1991, The Newcastle Child Depression Project Diagnosis and Classification of Depression, British Journal of Psychiatry, 159, 9, 10.1192/S0007125000292106
Kutcher, 1995, The Depressed and Adolescent – Developmental and Clinical Perspectives, 195
Sapolsky, 1991, Stress, Neurobiology and Neuroendocrinology, 293
Rosenberg, 1979, Conceiving the Self
Tanner, 1978, Foetus into Man: From Conception to Maturity
Wu, 1992, Pregnenolone sulphate: a positive allosteric modulator at the N-methyl-D-aspartate receptor, Molecular Pharmacology, 40, 333