Adrenal secretion during major depression in 8- to 16-year-olds, I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation

Psychological Medicine - Tập 26 Số 2 - Trang 245-256 - 1996
Ian M. Goodyer1, J. Herbert1, P. M. E. Altham1, John Pearson1, SANDRA M. SECHER1, H. M. Shiers1
1Developmental Psychiatry Section, Department of Psychiatry, Department of Anatomy, MRC Cambridge Centre for Brain Repair and the Statistical Laboratory, University of Cambridge

Tóm tắt

SynopsisThe association between basal cortisol, dehydroepiandrosterone (DHEA), its sulphate (DHEAS) and major depression was investigated in 8- to 16-year-olds. Eighty-two subjects with major depression, 25 non-depressed psychiatric cases and 40 community controls were systematically assessed for current mental state and hormone levels at 08.00, 12.00 and 20.00 h, assayed from salivary samples collected over a 48 h period. The average mean of the two time points was compared between the three groups. Evening cortisol hypersecretion and morning DHEA hyposecretion were significantly, and independently, associated with major depression. High evening cortisol (> 0·594 ng/ml) and low morning DHEA (< 0·200 ng/ml) identified subgroups of depressives with different types of adrenal hormone dysregulation. The association between high evening cortisol or low morning DHEA and MDD was not affected by either age or gender.

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Tài liệu tham khảo

10.1210/jcem-60-5-947

Kutcher, 1989, Parameters of adolescent depression, Psychiatric Clinics of North America, 12, 895, 10.1016/S0193-953X(18)30403-9

10.1016/0006-3223(89)90102-9

1987, Diagnostic and Statistical Manual of Mental Disorders

10.1016/S0002-7138(09)60602-6

Aitkin, 1989, Statistical Modelling in GLIM

10.1016/0301-0082(92)90025-A

Osran, 1993, Adrenal androgens and cortisol in major depression, American Journal of Psychiatry, 150, 806, 10.1176/ajp.150.5.806

Akina, 1992, The incidence on non-classical 21-hydroxylase deficiency in hirsute adolescent girls, Gynecological Endocrinology, 6, 99, 10.3109/09513599209046392

10.1097/00004583-199105000-00009

10.1097/00019616-199311000-00005

10.1210/endo-129-6-3174

10.1097/00004583-198811000-00011

10.1017/S0954579400005538

Walker, 1982, Immunoassay of Steroids in Saliva, 308

Guazzo E. , Kirkpatrick P. J. , Goodyer I. M. , Shiers H. M. & Herbert J. (1995). Cortisol, dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) in the cerebrospinal fluid of man: relation to blood levels and the effects of age. Journal of Clinical Endocrinology and Metabolism (in the press).

10.1016/0306-4530(94)90064-7

Reynolds, 1983, National normative and reliability data for the revised children's manifest anxiety scale, School Psychology Review, 12, 324, 10.1080/02796015.1983.12085047

10.1001/archpsyc.1983.01790100074010

Goodyer, 1991, Life Experiences, Development and Child Psychopathology

10.1097/00004583-199203000-00017

10.1016/0306-4530(91)90032-O

10.1159/000182306

Puig-Antich, 1989, Cortisol secretion in prepubertal children with major depressive disorder. Episode and recovery, Archives of General Psychiatry, 46, 801, 10.1001/archpsyc.1989.01810090043008

10.1210/jcem-56-4-668

10.1017/S0033291700034656

10.1097/00004583-198811000-00014

Spratt, 1993, Differential changes in serum concentrations of androgens and estrogens (in relation with cortisol) in postmenopausal women with acute illness, Journal of Clinical Endocrinology and Metabolism, 76, 1542

10.1016/0006-3223(91)90067-V

10.1111/j.1469-7610.1988.tb00719.x

Goodyer, 1995, The Depressed Child and Adolescent: Developmental and Clinical Perspectives

Kolvin, 1991, The Newcastle Child Depression Project Diagnosis and Classification of Depression, British Journal of Psychiatry, 159, 9, 10.1192/S0007125000292106

Kutcher, 1995, The Depressed and Adolescent – Developmental and Clinical Perspectives, 195

10.1007/978-1-4899-3242-6

10.1016/0300-9629(93)90022-V

10.1001/archpsyc.1985.01790300064008

Sapolsky, 1991, Stress, Neurobiology and Neuroendocrinology, 293

10.1055/s-2007-1013493

Rosenberg, 1979, Conceiving the Self

Tanner, 1978, Foetus into Man: From Conception to Maturity

Wu, 1992, Pregnenolone sulphate: a positive allosteric modulator at the N-methyl-D-aspartate receptor, Molecular Pharmacology, 40, 333

10.1111/j.1600-0447.1989.tb01295.x

Barrat-Connor, 1990, The Biologic Role of Dihydroepiandrosterone, 281, 10.1515/9783110847383-018

10.1192/bjp.163.3.369

10.1007/978-1-4899-4475-7

10.1016/0165-1781(91)90060-3

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Psychological Medicine

Tập 26 Số 2

245-256

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