Polymorphisms of the cytomegalovirus glycoprotein B genotype in patients with Posner-Schlossman syndrome

British Journal of Ophthalmology - Tập 106 Số 9 - Trang 1240-1244 - 2022
Ruyi Zhai1,2,3,4, Zhujian Wang5, Qilian Sheng1,2,3,4, Xintong Fan1,2,3,4, Xiangmei Kong6, Xinghuai Sun1,2,3,4,7
1Department of Ophthalmology and Vision Science, Eye & ENT Hospital, Fudan University, Shanghai, China
2Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China
3NHC Key Laboratory of Myopia (Fudan University), Shanghai, China
4Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, China
5Department of Clinical Laboratory, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China
6Department of Ophthalmology and Vision Science, Fudan University Eye Ear Nose and Throat Hospital Department of Ophthalmology, Shanghai 200032, China
7State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China

Tóm tắt

AimsThe aim of this observational study was to report the distribution of glycoprotein B (gB) genotypes in the eyes of cytomegalovirus (CMV) positive patients with Posner-Schlossman syndrome (PSS), and to investigate their clinical characteristics and outcomes.MethodsWe collected aqueous humour samples from 165 patients clinically diagnosed with PSS between 2017 and 2019. PCR was performed to analyse the CMV DNA and identify the gB genotypes in the samples. Clinical characteristics and responses to antiviral treatment were compared among patients with different gB genotypes.ResultsCMV DNA was detected in 94 (56.97%) of the 165 aqueous humour specimens analysed. Owing to the quantity requirement for CMV gB genotype analysis, results could be obtained from only 14 specimens. CMV gB type 1 was detected in 11 samples (78.6%), whereas CMV gB type 3 was detected in three samples (21.4%). No other gB genotypes or mixed genotypes were detected. Overall, 9.1% (1/11) of the patients in the gB type 1 group and 66.7% (2/3) of the patients in the gB type 3 group had bilateral attacks (p=0.093). The concentration of anti-CMV immunoglobulin G (IgG) in the type 1 group was 0.94±0.79 s/co (ratio of aqueous humour CMV IgG/serum CMV IgG to aqueous humour albumin concentration/serum albumin concentration), whereas that in the type 3 group was 0.67±0.71 s/co.ConclusionGenotype 1 was the most prevalent genotype in the aqueous humour of CMV-infected patients with PSS. Bilateral attack was predominant among patients with gB genotype 3. CMV gB gene may be related to the pathogenicity of CMV virus strain in patients with PSS.

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British Journal of Ophthalmology

Tập 106 Số 9

1240-1244

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