Prediction of Individual Brain Maturity Using fMRI

American Association for the Advancement of Science (AAAS) - Tập 329 Số 5997 - Trang 1358-1361 - 2010
Nico U.F. Dosenbach1, Binyam Nardos1, Alexander L. Cohen1, Damien A. Fair2, Jonathan D. Power1, Jessica A. Church1, Scott M. Nelson1,3, Gagan S. Wig4,1,5, Alecia C. Vogel1, Christina N. Lessov‐Schlaggar6, Kelly A. Barnes1, Joseph W. Dubis1, Eric Feczko6, Rebecca S. Coalson1,7, John R. Pruett6, Deanna M. Barch6,3,7, Steven E. Petersen8,1,3,7, Bradley L. Schlaggar8,1,9,7
1Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
2Department of Psychiatry, Oregon Health and Science University, Portland, OR 97239, USA.
3Department of Psychology, Washington University, St. Louis, MO 63130 USA
4Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
5Department of Psychology, Harvard University, Cambridge, MA 02138, USA
6Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA.
7Department of Radiology, Washington University School of Medicine, St. Louis, Mo 63110, USA.
8Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110 USA
9Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

Tóm tắt

Connectivity Map of the Brain The growing appreciation that clinically abnormal behaviors in children and adolescents may be influenced or perhaps even initiated by developmental miscues has stoked an interest in mapping normal human brain maturation. Several groups have documented changes in gray and white matter using structural and functional magnetic resonance imaging (fMRI) in cross-sectional and longitudinal studies. Dosenbach et al. (p. 1358 ) developed an index of resting-state functional connectivity (that is, how tightly neuronal activities in distinct brain regions are correlated while the subject is at rest or even asleep) from analyses of three independent data sets (each based on fMRI scans of 150 to 200 individuals from ages 6 to 35 years old). Long-range connections increased with age and short-range connections decreased, indicating that networks become sparser and sharper with brain maturation.

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American Association for the Advancement of Science (AAAS)

Tập 329 Số 5997

1358-1361

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