The lipin family: mutations and metabolism

Current Opinion in Lipidology - Tập 20 Số 3 - Trang 165-170 - 2009
Karen Reue1,2,3,4
1Departments of Human Genetics and Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
2e-mail: [email protected]
3fax: +1 310 794 5446
4to Karen Reue, Department of Human Genetics, Gonda 6506A, 695 Charles E. Young Drive South, Los Angeles, CA 90095, USA Tel: +1 310 794 5631

Tóm tắt

Từ khóa


Tài liệu tham khảo

Garg, 2004, Acquired and inherited lipodystrophies, N Engl J Med, 350, 1220, 10.1056/NEJMra025261

Smyth, 2006, Diabetes and obesity: the twin epidemics, Nat Med, 12, 75, 10.1038/nm0106-75

Lusis, 2008, Metabolic syndrome: from epidemiology to systems biology, Nat Rev Genet, 9, 819, 10.1038/nrg2468

Carman, 2009, Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis, J Biol Chem, 284, 2593, 10.1074/jbc.R800059200

Carman, 2007, Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae, J Biol Chem, 282, 37293, 10.1074/jbc.R700038200

Langner, 1989, The fatty liver dystrophy (fld) mutation. A new mutant mouse with a developmental abnormality in triglyceride metabolism and associated tissue-specific defects in lipoprotein lipase and hepatic lipase activities, J Biol Chem, 264, 7994, 10.1016/S0021-9258(18)83141-6

Langner, 1991, Characterization of the peripheral neuropathy in neonatal and adult mice that are homozygous for the fatty liver dystrophy (fld) mutation, J Biol Chem, 266, 11955, 10.1016/S0021-9258(18)99050-2

Péterfy, 2001, Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin, Nat Genet, 27, 121, 10.1038/83685

Huffman, 2002, Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin, Proc Natl Acad Sci U S A, 99, 1047, 10.1073/pnas.022634399

Reue, 2008, Thematic review series: glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism, J Lipid Res, 49, 2493, 10.1194/jlr.R800019-JLR200

Donkor, 2007, Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns, J Biol Chem, 282, 3450, 10.1074/jbc.M610745200

Han, 2006, The Saccharomyces cerevisiae lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme, J Biol Chem, 281, 9210, 10.1074/jbc.M600425200

Harris, 2007, Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1, J Biol Chem, 282, 277, 10.1074/jbc.M609537200

Bou Khalil, 2008, The level and compartmentalization of phosphatidate phosphatase-1 (lipin-1) control the assembly and secretion of hepatic very low density lipoproteins, J Lipid Res, 50, 47, 10.1194/jlr.M800204-JLR200

Péterfy, 2005, Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis, J Biol Chem, 280, 32883, 10.1074/jbc.M503885200

Finck, 2006, Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway, Cell Metab, 4, 199, 10.1016/j.cmet.2006.08.005

Phan, 2004, Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro, J Biol Chem, 279, 29558, 10.1074/jbc.M403506200

Phan, 2005, Lipin, a lipodystrophy and obesity gene, Cell Metab, 1, 73, 10.1016/j.cmet.2004.12.002

Zeharia, 2008, Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood, Am J Hum Genet, 83, 1, 10.1016/j.ajhg.2008.09.002

Grimsey, 2008, Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2, J Biol Chem, 283, 29166, 10.1074/jbc.M804278200

Sirvent, 2008, New insights into mechanisms of statin-associated myotoxicity, Curr Opin Pharmacol, 8, 333, 10.1016/j.coph.2007.12.010

Higashida, 2008, Potential role of lipin-1 in exercise-induced mitochondrial biogenesis, Biochem Biophys Res Commun, 374, 587, 10.1016/j.bbrc.2008.07.079

El-Shanti, 2007, Chronic recurrent multifocal osteomyelitis: a concise review and genetic update, Clin Orthop Relat Res, 462, 11, 10.1097/BLO.0b013e3180986d73

Ferguson, 2005, Homozygous mutations in LPIN2 are responsible for the syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia (Majeed syndrome), J Med Genet, 42, 551, 10.1136/jmg.2005.030759

Majeed, 2001, The syndrome of chronic recurrent multifocal osteomyelitis and congenital dyserythropoietic anaemia. Report of a new family and a review, Eur J Pediatr, 160, 705, 10.1007/s004310100799

Milhavet, 2008, The infevers autoinflammatory mutation online registry: update with new genes and functions, Hum Mutat, 29, 803, 10.1002/humu.20720

Miranda, 2007, Human subcutaneous adipose tissue LPIN1 expression in obesity, type 2 diabetes mellitus, and human immunodeficiency virus–associated lipodystrophy syndrome, Metabolism, 56, 1518, 10.1016/j.metabol.2007.06.019

Suviolahti, 2006, Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism, Hum Mol Genet, 15, 377, 10.1093/hmg/ddi448

Yao-Borengasser, 2006, Lipin expression is attenuated in adipose tissue of insulin-resistant human subjects and increases with peroxisome proliferator-activated receptor gamma activation, Diabetes, 55, 2811, 10.2337/db05-1688

Lindegaard, 2006, Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophy, Int J Obes, 31, 449, 10.1038/sj.ijo.0803434

Donkor, 2008, Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men, J Clin Endocrinol Metab, 93, 233, 10.1210/jc.2007-1535

Croce, 2007, Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss, Diabetes, 56, 2395, 10.2337/db07-0480

Mlinar, 2008, Decreased lipin 1{beta} expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome, Eur J Endocrinol, 159, 833, 10.1530/EJE-08-0387

Fawcett, 2008, Evaluating the role of LPIN1 variation on insulin resistance, body weight and human lipodystrophy in UK populations, Diabetes, 57, 2527, 10.2337/db08-0422

Wiedmann, 2008, Genetic variants within the LPIN1 gene, encoding lipin, are influencing phenotypes of the metabolic syndrome in humans, Diabetes, 57, 209, 10.2337/db07-0083

Loos, 2007, Association of lipin 1 gene polymorphisms with measures of energy and glucose metabolism, Obesity (Silver Spring), 15, 2723, 10.1038/oby.2007.324

Kang, 2008, LPIN1 genetic variation is associated with rosiglitazone response in type 2 diabetic patients, Mol Genet Metab, 95, 96, 10.1016/j.ymgme.2008.06.011

Ong, 2008, Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men, Am J Hypertens, 21, 539, 10.1038/ajh.2008.21

Aulchenko, 2007, LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition, Diabetes, 56, 3020, 10.2337/db07-0338

Nadra, 2008, Phosphatidic acid mediates demyelination in Lpin1 mutant mice, Genes Dev, 22, 1647, 10.1101/gad.1638008

Andresen, 2002, The role of phosphatidic acid in the regulation of the Ras/MEK/Erk signaling cascade, FEBS Lett, 531, 65, 10.1016/S0014-5793(02)03483-X

Chen, 2008, Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion, Arterioscler Thromb Vasc Biol, 28, 1738, 10.1161/ATVBAHA.108.171538

Manmontri, 2008, Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically, J Lipid Res, 49, 1056, 10.1194/jlr.M800013-JLR200

Kim, 2007, A conserved phosphatase cascade that regulates nuclear membrane biogenesis, Proc Natl Acad Sci U S A, 104, 6596, 10.1073/pnas.0702099104

Zhang, 2008, Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis, J Lipid Res, 49, 1519, 10.1194/jlr.M800061-JLR200

Koh, 2008, Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein α and peroxisome proliferator-activated receptor γ2, J Biol Chem, 50, 34896, 10.1074/jbc.M804007200

Waki, 2007, The small molecule harmine is an antidiabetic cell-type specific regulator of PPARγ expression, Cell Metab, 5, 357, 10.1016/j.cmet.2007.03.010

van Harmelen, 2007, A role of lipin in human obesity and insulin resistance: relation to adipocyte glucose transport and GLUT4 expression, J Lipid Res, 48, 201, 10.1194/jlr.M600272-JLR200

Gowri, 2007, Lipin1 regulation by estrogen in uterus and liver: implications for diabetes and fertility, Endocrinology, 148, 3685, 10.1210/en.2006-1728

Lu, 2008, LPS and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3T3-L1 adipocytes, Am J Physiol Endocrinol Metab, 295, E1502, 10.1152/ajpendo.90323.2008

Gropler, 2009, Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice, J Biol Chem, 284, 6763, 10.1074/jbc.M807882200