The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity

Nature Medicine - Tập 19 Số 2 - Trang 232-237 - 2013
Adam Collison1,2, Luke Hatchwell1,2, Nicole M. Verrills3, Peter Wark4,2, Ana Pereira de Siqueira1,2, Melinda Tooze4,2, Helen Carpenter3, Anthony S. Don5, Jonathan C. Morris6, Nives Zimmermann7, Nathan W. Bartlett8, Marc E. Rothenberg7, Sebastian L. Johnston8, Paul S. Foster2, Joërg Mattes1,9,2
1Experimental and Translational Respiratory Group, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia
2Priority Research Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia
3Discipline of Medical Biochemistry, School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, Australia
4Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia
5Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia
6School of Chemistry, University of New South Wales, Sydney, Australia
7Department of Pediatrics, Division of Allergy and Immunology, Children's Hospital Medical Center, University of Cincinnati, Cincinnati, USA
8Section of Airway Disease Infection, National Heart and Lung Institute, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, UK
9Paediatric Respiratory and Sleep Medicine Unit, Newcastle Children's Hospital, Kaleidoscope, Newcastle, Australia

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