Antihyperlipidemic Effects of Salvia officinalis L. Leaf Extract in Patients with Hyperlipidemia: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial

Phytotherapy Research - Tập 25 Số 12 - Trang 1849-1853 - 2011
Saeed Kianbakht1,2, Behrooz Abasi3, M. Perham4, Farid Dabaghian5
1Department of Pharmacology and Applied Medicine, Research Institute of Medicinal Plants, ACECR, Karaj, Iran
2Dr S. Kianbakht, Research Institute of Medicinal Plants, Research Complex of Iranian Academic Center for Education, Culture and Research (ACECR), Kavosh Boulevard, Supa Boulevard, 55th Kilometer of Tehran-Gazvin Freeway, Pouleh Kordan, Karaj, Iran.
3Diabetes Clinic, Karaj, Iran
4Department of Endocrinology, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran
5Research Institute for Islamic and Complementary Medicine, Tehran University of Medical Sciences, Tehran, Iran

Tóm tắt

Hyperlipidemia is a common metabolic disorder contributing to morbidities and mortalities due to cardiovascular and cerebrovascular diseases. Conventional antihyperlipidemic drugs have limited efficacies and important side effects, so that alternative lipid lowering agents are needed. Salvia officinalis L. (sage) leaves have PPAR γ agonistic, pancreatic lipase and lipid absorption inhibitory, antioxidant, lipid peroxidation inhibitory and antiinflammatory effects. Thus, in this randomized double‐blind placebo‐controlled clinical trial with 67 hyperlipidemic (hypercholesterolemic and/or hypertriglyceridemic) patients aged 56.4 ± 30.3 years (mean ± SD), the effects of taking sage leaf extract (one 500 mg capsule every 8 h for 2 months) on fasting blood levels of lipids, creatinine and liver enzymes including SGOT and SGPT were evaluated in 34 patients and compared with the placebo group (n = 33). The extract lowered the blood levels of total cholesterol (p < 0.001), triglyceride (p = 0.001), LDL (p = 0.004) and VLDL (p = 0.001), but increased the blood HDL levels (p < 0.001) without any significant effects on the blood levels of SGOT, SGPT and creatinine (p > 0.05) compared with the placebo group at the endpoint. No adverse effects were reported. The results suggest that sage may be effective and safe in the treatment of hyperlipidemia. Copyright © 2011 John Wiley & Sons, Ltd.

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Phytotherapy Research

Tập 25 Số 12

1849-1853

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