Circadian variation in cell division of the mouse alimentary tract, bone marrow and corneal epithelium

Wiley - Tập 191 Số 4 - Trang 479-486 - 1978
Lawrence E. Scheving1, E. Robert Burns1, John E. Pauly1, T H Tsai1
1Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72201

Tóm tắt

AbstractCircadian rhythms in DNA synthesis are described for the tongue epithelium, five different regions of the alimentary canal (gut) –esophagus, stomach, duodenum, jejunum and rectum– and bone marrow in a group of BDF1 male mice. A circadian rhythm is also described for the mitotic index in the corneal epithelium in the same mice. The data document for the first time in the same animals the dramatic variation in cell division encountered from one region of the gut to another. This variation is seen in the amplitudes of the rhythms as well as in the over‐all 24‐hour means. On the contrary, the phasings of the rhythms in the different regions of the gut are remarkably similar. In this study, where the mice were standardized to 12 hours of light (0600‐1800) alternating with 12 hours of darkness, the peak of the DNA‐synthesis rhythm occurred around the time of transition from dark to light, and the trough around the time of transition from light to dark. The implications of these findings, and those of others, to the study of cell kinetics and to cancer chemotherapy are discussed.

Từ khóa


Tài liệu tham khảo

10.1159/000141580

10.1007/BF02477020

Burns E. R., 1975, Circadian influence on the wave form of the frequency of labeled mitoses in the mouse corneal epithelium, Cell Tissue Kinet., 8, 61

Burns E. R., 1976, Effect of altered lighting regimens, time‐ limited feeding, and presence of Ehrlich ascites carcinoma on the circadian rhythm in DNA synthesis of mouse spleen, Cancer Research, 36, 1538

Chumak M. G., 1963, Mitotic cycle of epithelium cells in cornea in mice, by means of thymidine tagged with tritium, Dokl. Akad. Nauk. SSSR, 149, 960

10.1126/science.177.4043.80

Hunt T. E., 1952, Mitotic activity in the gastric glands of the rat, Anat. Rec., 112, 346

Kuhl J. F. W., 1974, Experimental chronotherapy with ara‐C: comparison of murine ara‐C tolerance on differently timed treatment schedules, Chronobiologia, 1, 316

10.1002/ar.1091000306

10.1159/000141150

Ogur M., 1970, The nucleic acids of plant tissues. I. The nucleic acid, Arch. Biochem., 25, 262

10.1038/199863a0

10.1016/0014-4827(59)90063-1

10.1083/jcb.32.3.677

Scheving L. E., 1973, Cellular mechanisms involving biorhythms with emphasis on those rhythms associated with the S and M stages of the cell cycle, Int. J. Chronobiology, 1, 269

10.1002/aja.1001350302

Scheving L. E., 1977, Can chronobiology be ignored when considering the cancer problem? In: Proceedings of the Third International Symposium on Detection and Prevention of Cancer, 1063

Scheving L. E. E. R.BurnsandJ. E.Pauly1977bCoincidence in timing between the S and M stages of the cell cycle in liver parenchymal cells in mice bearing an 8‐day Ehrlich ascites tumor (EAT). In: Proceedings of the XIIth International Conference of Chronobiology Washington D. C. August 10‐13 1975.

Casa Editrice “Il Ponte”, 427

Scheving L. E., 1977, Survival and cure of leukemic mice after optimization of treatment with cyclophosphamide and arabinosyl cytosine, Cancer Res., 37, 3648

Scheving L. E., 1975, Close reproduction by different laboratories of characteristics of circadian rhythm to 1‐β‐D‐arabinofuranosylcytosine tolerance by mice, Cancer Res., 36, 1113

10.1016/0014-4827(69)90126-8

Tvermyr E. M., 1972, Circadian rhythms in hairless mouse epidermal DNA synthesis as measured by double labeling with H3‐thymidine, Virchows Arch., Abt. B. Zellpath., 11, 45, 10.1007/BF02889385

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Wiley

Tập 191 Số 4

479-486

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