Dietary oligochitosan supplementation enhances immune status of broilers

Journal of the Science of Food and Agriculture - Tập 87 Số 1 - Trang 153-159 - 2007
Rui‐Lin Huang1,2, Zeyuan Deng1,2, Chengbo Yang2, Yulong Yin1,2, Ming Xie2, Guoyao Wu3,4, Tiejun Li2, Lili Li2, Zhi-Ru Tang2, Ping Kang2, Zhenping Hou2, Dun Deng2, Hua Xiang1, Xiang Feng Kong2, Yuming Guo5
1Key Laboratory of Food Science of Ministry of Education of China, Department of Food Science & Engineering, Nanchang University, Nanchang 330047, People's Republic of China
2Laboratory of Animal Nutrition and Health and Key Laboratory of Subtropical Agro-ecology, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan 410125, P.O.Box 10, Hunan 410125, People's Republic of China
3Department of Animal Science, Texas A&M University, College Station, TX 7843-2471, USA
4Laboratory of Animal Nutrition and Health and Key Laboratory of Subtropical Agro‐ecology, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, Hunan 410125, P.O.Box 10, Hunan 410125, People's Republic of China
5The College of Animal Science, China Agricultural University, Beijing, People's Republic of China

Tóm tắt

AbstractOligochitosan (COS) is a type of prebiotic, which favourably alters the intestinal microflora balance, inhibits the growth of harmful bacteria, promotes good digestion and boosts immune function. The effect of dietary COS supplementation on immune function in broilers was assessed by feeding graded levels (0, 50, 100, 150 mg kg−1) of COS. Two thousand four hundred male commercial Avian® broilers (1 day old) were assigned randomly to five dietary treatment groups (60 birds/pen with eight pens per treatment). Diet A was a typical maize‐ and soybean meal‐based diet supplemented with 6 mg kg−1 antibiotics of flavomycin (positive control). Diet B was the basal diet without any supplement. Diets C, D and E were formulated by addition of 50, 100, 150 mg kg−1 of COS to the basal diet, respectively. On the morning of days 21 and 42, a total of 64 (eight birds/pen with eight pens per treatment) of the growth experimental birds were killed by cervical dislocation, respectively for determination of serum concentrations of IgG, IgA and IgM, and weights of spleen, bursa and thymus. Compared with broilers fed the control and the positive control diets, dietary supplementation with COS increased (P < 0.001) serum concentrations of IgG, IgA, and IgM, with the greatest response for the 100 mg kg−1COS supplementation. Chitosan oligosaccharides supplementation also enhanced the immune organ development. Results suggest COS can improve immune response in birds. Through positive modulation of the immune response, COS has great potential as an effective, antibiotic‐like growth promoter for poultry. Copyright © 2006 Society of Chemical Industry

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Journal of the Science of Food and Agriculture

Tập 87 Số 1

153-159

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