Gallagher R, Appenzeller T: Beyond reductionism. Science 1999, 284: 79. 10.1126/science.284.5411.79
Marshall JC: SIRS and MODS: what is their relevance to the science and practice of intensive care? Shock 2000, 14: 586-589.
Seely AJ, Christou NV: Multiple organ dysfunction syndrome: exploring the paradigm of complex nonlinear systems. Crit Care Med 2000, 28: 2193-2200. 10.1097/00003246-200007000-00003
Glass L MM: From Clocks to Chaos: The Rhythms of Life Princeton: Princeton University Press 1988.
Que CL, Kenyon CM, Olivenstein R, Macklem PT, Maksym GN: Homeokinesis and short-term variability of human airway caliber. J Appl Physiol 2001, 91: 1131-1141.
Glass L, Kaplan D: Time series analysis of complex dynamics in physiology and medicine. Med Prog Technol 1993, 19: 115-128.
Que CL, Maksym G, Macklem PT: Deciphering the homeokinetic code of airway smooth muscle. Am J Respir Crit Care Med 2000, 161: S161-S163.
Cunningham S, Symon AG, McIntosh N: The practical management of artifact in computerised physiological data. Int J Clin Monit Comput 1994, 11: 211-216. 10.1007/BF01139872
Sapoznikov D, Luria MH, Mahler Y, Gotsman MS: Computer processing ofartifact and arrhythmias in heart rate variability analysis. Comput Methods Programs Biomed 1992, 39: 75-84. 10.1016/0169-2607(92)90060-K
Berntson GG, Quigley KS, Jang JF, Boysen ST: An approach to artifact identification: application to heart period data. Psychophysiology 1990, 27: 586-598.
Anonymous: Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996, 93: 1043-1065.
van Ravenswaaij-Arts CM, Kollee LA, Hopman JC, Stoelinga GB, van Geijn HP: Heart rate variability. Ann Intern Med 1993, 118: 436-447.
Mietus JE, Peng CK, Henry I, Goldsmith RL, Goldberger AL: The pNNx files: re-examining a widely used heart rate variability measure. Heart 2002, 88: 378-380. 10.1136/heart.88.4.378
Rich MW, Saini JS, Kleiger RE, Carney RM, teVelde A, Freedland KE: Correlation of heart rate variability with clinical and angiographic variables and late mortality after coronary angiography. Am J Cardiol 1988, 62: 714-717. 10.1016/0002-9149(88)91208-8
Van Hoogenhuyze D, Weinstein N, Martin GJ, Weiss JS, Schaad JW, Sahyouni XN, Fintel D, Remme WJ, Singer DH: Reproducibility and relation to meanheart rate of heart rate variability in normal subjects and in patients with congestive heart failure secondary to coronary artery disease. Am J Cardiol 1991, 68: 1668-1676. 10.1016/0002-9149(91)90327-H
Tuininga YS, van Veldhuisen DJ, Brouwer J, Haaksma J, Crijns HJ, Man in't Veld AJ, Lie KI: Heart rate variability in left ventricular dysfunction and heart failure: effects and implications of drug treatment. Br Heart J 1994, 72: 509-513.
Szabo BM, van Veldhuisen DJ, van der Veer N, Brouwer J, De Graeff PA, Crijns HJ: Prognostic value of heart rate variability in chronic congestive heart failure secondary to idiopathic or ischemic dilated cardiomyopathy. Am J Cardiol 1997, 79: 978-980. 10.1016/S0002-9149(97)00026-X
Ponikowski P, Anker SD, Chua TP, Szelemej R, Piepoli M, Adamopoulos S, Webb-Peploe K, Harrington D, Banasiak W, Wrabec K, et al.: Depressed heart rate variability as an independent predictor of death in chronic congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 1997, 79: 1645-1650. 10.1016/S0002-9149(97)00215-4
Bigger JT Jr, Kleiger RE, Fleiss JL, Rolnitzky LM, Steinman RC, Miller JP: Components of heart rate variability measured during healing of acute myocardial infarction. Am J Cardiol 1988, 61: 208-215. 10.1016/0002-9149(88)90917-4
Kleiger RE, Miller JP, Bigger JT Jr, Moss AJ: Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987, 59: 256-262. 10.1016/0002-9149(87)90795-8
Casolo GC, Stroder P, Signorini C, Calzolari F, Zucchini M, Balli E, Sulla A, Lazzerini S: Heart rate variability during the acute phase of myocardial infarction. Circulation 1992, 85: 2073-2079.
Singh N, Mironov D, Armstrong PW, Ross AM, Langer A: Heart rate variability assessment early after acute myocardial infarction. Pathophysiological and prognostic correlates. GUSTO ECG Substudy Investigators. Global Utilization of Streptokinase and TPA for Occluded Arteries. Circulation 1996, 93: 1388-1395.
Zuanetti G, Neilson JM, Latini R, Santoro E, Maggioni AP, Ewing DJ: Prognostic significance of heart rate variability in post-myocardial infarction patients in the fibrinolytic era. The GISSI-2 results. Gruppo Italiano per lo Studio della Sopravvivenza nell' Infarto Miocardico. Circulation 1996, 94: 432-436.
Tsuji H, Venditti FJ Jr, Manders ES, Evans JC, Larson MG, Feldman CL, Levy D: Reduced heart rate variability and mortality risk in an elderlycohort. The Framingham Heart Study. Circulation 1994, 90: 878-883.
Lurje L, Wennerblom B, Tygesen H, Karlsson T, Hjalmarson A: Heart rate variability after acute myocardial infarction in patients treated with atenolol and metoprolol. Int J Cardiol 1997, 60: 157-164. 10.1016/S0167-5273(97)00104-6
Osterhues HH, Kochs M, Hombach V: Time-dependent changes of heart rate variability after percutaneous transluminal angioplasty. Am Heart J 1998, 135: 755-761. 10.1016/S0002-8703(98)70033-X
Wennerblom B, Lurje L, Solem J, Tygesen H, Uden M, Vahisalo R, Hjalmarson A: Reduced heart rate variability in ischemic heart disease is only partially caused by ischemia. An HRV study before and after PTCA. Cardiology 2000, 94: 146-151. 10.1159/000047309
Dimmer C, Tavernier R, Gjorgov N, Van Nooten G, Clement DL, Jordaens L: Variations of autonomic tone preceding onset of atrial fibrillation after coronary artery bypass grafting. Am J Cardiol 1998, 82: 22-25. 10.1016/S0002-9149(98)00231-8
Malik M, Camm AJ, Janse MJ, Julian DG, Frangin GA, Schwartz PJ: Depressed heart rate variability identifies postinfarction patients who might benefit from prophylactic treatment with amiodarone: a substudy of EMIAT (The European Myocardial Infarct Amiodarone Trial). J Am Coll Cardiol 2000, 35: 1263-1275. 10.1016/S0735-1097(00)00571-4
Kleiger RE, Stein PK, Bosner MS, Rottman JN: Time domain measurements of heart rate variability. Cardiol Clin 1992, 10: 487-498.
Stein PK: Assessing heart rate variability from real-world Holter reports. Card Electrophysiol Rev 2002, 6: 239-244. 10.1023/A:1016376924850
Zhang CL, Popp FA: Log-normal distribution of physiological parameters and the coherence of biological systems. Med Hypotheses 1994, 43: 11-16. 10.1016/0306-9877(94)90042-6
Tibby SM, Frndova H, Durward A, Cox PN: Novel method to quantify loss of heart rate variability in pediatric multiple organ failure. Crit Care Med 2003, 31: 2059-2067. 10.1097/01.CCM.0000069539.65980.58
Stanley HE, Amaral LA, Goldberger AL, Havlin S, Ivanov P, Peng CK: Statistical physics and physiology: monofractal and multifractal approaches. Physica A 1999, 270: 309-324. 10.1016/S0378-4371(99)00230-7
Sayers BM: Analysis of heart rate variability. Ergonomics 1973, 16: 17-32.
Akselrod S, Gordon D, Ubel FA, Shannon DC, Berger AC, Cohen RJ: Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. Science 1981, 213: 220-222.
Campbell MJ: Spectral analysis of clinical signals: an interface between medical statisticians and medical engineers. Stat Methods Med Res 1996, 5: 51-66.
Mehta SK, Super DM, Connuck D, Salvator A, Singer L, Fradley LG, Harcar-Sevcik RA, Kirchner HL, Kaufman ES: Heart rate variability in healthy newborn infants. Am J Cardiol 2002, 89: 50-53. 10.1016/S0002-9149(01)02162-2
Bigger JT Jr, Fleiss JL, Steinman RC, Rolnitzky LM, Kleiger RE, Rottman JN: Correlations among time and frequency domain measures of heart period variability two weeks after acute myocardial infarction. Am J Cardiol 1992, 69: 891-898. 10.1016/0002-9149(92)90788-Z
Pagani M, Lombardi F, Guzzetti S, Rimoldi O, Furlan R, Pizzinelli P, Sandrone G, Malfatto G, Dell'Orto S, Piccaluga E, et al.: Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res 1986, 59: 178-193.
Kamath MV, Fallen EL: Power spectral analysis of heart rate variability: a noninvasive signature of cardiac autonomic function. Crit Rev Biomed Eng 1993, 21: 245-311.
Pagani M, Montano N, Porta A, Malliani A, Abboud FM, Birkett C, Somers VK: Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. Circulation 1997, 95: 1441-1448.
Stein PK, Kleiger RE: Insights from the study of heart rate variability. Annu Rev Med 1999, 50: 249-261. 10.1146/annurev.med.50.1.249
Malik M: Heart rate variability. Curr Opin Cardiol 1998, 13: 36-44.
Notarius CF, Butler GC, Ando S, Pollard MJ, Senn BL, Floras JS: Dissociation between microneurographic and heart rate variability estimates of sympathetic tone in normal subjects and patients with heart failure. Clin Sci (Lond) 1999, 96: 557-565. 10.1042/CS19980347
Notarius CF, Floras JS: Limitations of the use of spectral analysis of heart rate variability for the estimation of cardiac sympathetic activity in heart failure. Europace 2001, 3: 29-38. 10.1053/eupc.2000.0136
Stauss HM: Heart rate variability. Am J Physiol Regul Integr Comp Physiol 2003, 285: R927-R931.
Parati G, Saul JP, Di Rienzo M, Mancia G: Spectral analysis of blood pressure and heart rate variability in evaluating cardiovascular regulation. Hypertension 1995, 25: 1276-1286.
Triedman JK, Cohen RJ, Saul JP: Mild hypovolemic stress alters autonomic modulation of heart rate. Hypertension 1993, 21: 236-247.
Guzzetti S, Mezzetti S, Magatelli R, Porta A, De Angelis G, Rovelli G, Malliani A: Linear and non-linear 24 h heart rate variability in chronic heart failure. Auton Neurosci 2000, 86: 114-119. 10.1016/S1566-0702(00)00239-3
van de Borne P, Montano N, Pagani M, Oren R, Somers VK: Absence of low-frequency variability of sympathetic nerve activity in severe heart failure. Circulation 1997, 95: 1449-1454.
Bonaduce D, Petretta M, Marciano F, Vicario ML, Apicella C, Rao MA, Nicolai E, Volpe M: Independent and incremental prognostic value of heart rate variability in patients with chronic heart failure. Am Heart J 1999, 138: 273-284. 10.1016/S0002-8703(99)70112-2
Guzzetti S, Piccaluga E, Casati R, Cerutti S, Lombardi F, Pagani M, Malliani A: Sympathetic predominance in essential hypertension: a studyemploying spectral analysis of heart rate variability. J Hypertens 1988, 6: 711-717.
Mussalo H, Vanninen E, Ikaheimo R, Laitinen T, Laakso M, Lansimies E, Hartikainen J: Heart rate variability and its determinants in patients with severe or mild essential hypertension. Clin Physiol 2001, 21: 594-604. 10.1046/j.1365-2281.2001.00359.x
van Boven AJ, Jukema JW, Haaksma J, Zwinderman AH, Crijns HJ, Lie KI: Depressed heart rate variability is associated with events in patients with stable coronary artery disease and preserved left ventricular function. REGRESS Study Group. Am Heart J 1998, 135: 571-576. 10.1016/S0002-8703(98)70269-8
Pardo Y, Merz CN, Paul-Labrador M, Velasquez I, Gottdiener JS, Kop WJ, Krantz DS, Rozanski A, Klein J, Peter T: Heart rate variability reproducibility and stability using commercially available equipment in coronary artery disease with daily life myocardial ischemia. Am J Cardiol 1996, 78: 866-870. 10.1016/S0002-9149(96)00458-4
Huang J, Sopher SM, Leatham E, Redwood S, Camm AJ, Kaski JC: Heart rate variability depression in patients with unstable angina. Am Heart J 1995, 130: 772-779. 10.1016/0002-8703(95)90076-4
Poulsen SH, Jensen SE, Moller JE, Egstrup K: Prognostic value of left ventricular diastolic function and association with heart rate variability after a first acute myocardial infarction. Heart 2001, 86: 376-380. 10.1136/heart.86.4.376
Axelrod S, Lishner M, Oz O, Bernheim J, Ravid M: Spectral analysis of fluctuations in heart rate: an objective evaluation of autonomic nervous control in chronic renal failure. Nephron 1987, 45: 202-206.
Lishner M, Akselrod S, Avi VM, Oz O, Divon M, Ravid M: Spectral analysis of heart rate fluctuations. A non-invasive, sensitive method for the early diagnosis of autonomic neuropathy in diabetes mellitus. J Auton Nerv Syst 1987, 19: 119-125. 10.1016/0165-1838(87)90005-1
Toweill DL, Kovarik WD, Carr R, Kaplan D, Lai S, Bratton S, Goldstein B: Linear and nonlinear analysis of heart rate variability during propofol anesthesia for short-duration procedures in children. Pediatr Crit Care Med 2003, 4: 308-314. 10.1097/01.PCC.0000074260.93430.6A
Yien HW, Hseu SS, Lee LC, Kuo TB, Lee TY, Chan SH: Spectral analysis of systemic arterial pressure and heart rate signals as a prognostic tool for the prediction of patient outcome in the intensive care unit. Crit Care Med 1997, 25: 258-266. 10.1097/00003246-199702000-00011
Barnaby D, Ferrick K, Kaplan DT, Shah S, Bijur P, Gallagher EJ: Heart rate variability in emergency department patients with sepsis. Acad Emerg Med 2002, 9: 661-670. 10.1197/aemj.9.7.661
Korach M, Sharshar T, Jarrin I, Fouillot JP, Raphael JC, Gajdos P, Annane D: Cardiac variability in critically ill adults: influence of sepsis. Crit Care Med 2001, 29: 1380-1385. 10.1097/00003246-200107000-00013
Schmidt HB, Werdan K, Muller-Werdan U: Autonomic dysfunction in the ICU patient. Curr Opin Crit Care 2001, 7: 314-322. 10.1097/00075198-200110000-00002
Goldstein B: On the importance of sympathovagal balance. Crit Care Med 2001, 29: 1483-1484. 10.1097/00003246-200107000-00035
Goldstein B, Fiser DH, Kelly MM, Mickelsen D, Ruttimann U, Pollack MM: Decomplexification in critical illness and injury: relationship between heart rate variability, severity of illness, and outcome. Crit Care Med 1998, 26: 352-357. 10.1097/00003246-199802000-00040
Annane D, Trabold F, Sharshar T, Jarrin I, Blanc AS, Raphael JC, Gajdos P: Inappropriate sympathetic activation at onset of septic shock: a spectral analysis approach. Am J Respir Crit Care Med 1999, 160: 458-465.
Mansier P, Clairambault J, Charlotte N, Medigue C, Vermeiren C, LePape G, Carre F, Gounaropoulou A, Swynghedauw B: Linear and non-linear analyses of heart rate variability: a minireview. Cardiovasc Res 1996, 31: 371-379. 10.1016/0008-6363(96)00009-0
Furlan R, Guzzetti S, Crivellaro W, Dassi S, Tinelli M, Baselli G, Cerutti S, Lombardi F, Pagani M, Malliani A: Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects. Circulation 1990, 81: 537-547.
Pinna GD, Maestri R, Di Cesare A, Colombo R, Minuco G: The accuracy of power-spectrum analysis of heart-rate variability from annotated RR lists generated by Holter systems. Physiol Meas 1994, 15: 163-179. 10.1088/0967-3334/15/2/006
Merri M, Farden DC, Mottley JG, Titlebaum EL: Sampling frequency of the electrocardiogram for spectral analysis of the heart rate variability. IEEE Trans Biomed Eng 1990, 37: 99-106. 10.1109/10.43621
Novak P, Novak V: Time/frequency mapping of the heart rate, blood pressure and respiratory signals. Med Biol Eng Comput 1993, 31: 103-110.
Di Rienzo M, Castiglioni P, Mancia G, Parati G, Pedotti A: 24 h sequential spectral analysis of arterial blood pressure and pulse interval in free-moving subjects. IEEE Trans Biomed Eng 1989, 36: 1066-1075. 10.1109/10.40813
Crowe JA, Gibson NM, Woolfson MS, Somekh MG: Wavelet transform as apotential tool for ECG analysis and compression. J Biomed Eng 1992, 14: 268-272.
Bak P: How Nature Works. New York: Copernicus-Springer-Verlag 1996.
Gisiger T: Scale invariance in biology: coincidence or footprint ofa universal mechanism? Biol Rev Camb Philos Soc 2001, 76: 161-209. 10.1017/S1464793101005607
Goldberger AL: Non-linear dynamics for clinicians: chaos theory, fractals, and complexity at the bedside. Lancet 1996, 347: 1312-1314. 10.1016/S0140-6736(96)90948-4
Mandelbrot B: The Fractal Geometry of Nature (French edition published 1975.) New York: Freeman 1983.
Kobayashi M, Musha T: 1/f fluctuation of heartbeat period. IEEE Trans Biomed Eng 1982, 29: 456-457.
Szeto HH, Cheng PY, Decena JA, Cheng Y, Wu DL, Dwyer G: Fractal properties in fetal breathing dynamics. Am J Physiol 1992, 263: R141-R147.
Fabry B, Maksym GN, Butler JP, Glogauer M, Navajas D, Fredberg JJ: Scaling the microrheology of living cells. Phys Rev Lett 2001, 87: 148102. 10.1103/PhysRevLett.87.148102
Suki B: Fluctuations and power laws in pulmonary physiology. Am J Respir Crit Care Med 2002, 166: 133-137. 10.1164/rccm.200202-152PP
Pikkujamsa SM, Makikallio TH, Sourander LB, Raiha IJ, Puukka P, Skytta J, Peng CK, Goldberger AL, Huikuri HV: Cardiac interbeat interval dynamics from childhood to senescence : comparison of conventional and new measures based on fractals and chaos theory. Circulation 1999, 100: 393-399.
Jokinen V, Syvanne M, Makikallio TH, Airaksinen KE, Huikuri HV: Temporal age-related changes in spectral, fractal and complexity characteristics of heart rate variability. Clin Physiol 2001, 21: 273-281. 10.1046/j.1365-2281.2001.00326.x
Bigger JT Jr, Steinman RC, Rolnitzky LM, Fleiss JL, Albrecht P, Cohen RJ: Power law behavior of RR-interval variability in healthy middle-aged persons, patients with recent acute myocardial infarction, and patients with heart transplants. Circulation 1996, 93: 2142-2151.
Huikuri HV, Makikallio TH, Airaksinen KE, Seppanen T, Puukka P, Raiha IJ, Sourander LB: Power-law relationship of heart rate variability as apredictor of mortality in the elderly. Circulation 1998, 97: 2031-2036.
Peng CK, Havlin S, Stanley HE, Goldberger AL: Quantification of scaling exponents and crossover phenomena in nonstationary heartbeat time series. Chaos 1995, 5: 82-87. 10.1063/1.166141
Peng CK, Buldyrev SV, Goldberger AL, Havlin S, Mantegna RN, Simons M, Stanley HE: Statistical properties of DNA sequences. Physica A 1995, 221: 180-192. 10.1016/0378-4371(95)00247-5
Peng CK, Buldyrev SV, Havlin S, Simons M, Stanley HE, Goldberger AL: Mosaic organization of DNA nucleotides. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 1994, 49: 1685-1689. 10.1103/PhysRevE.49.1685
Nunes Amaral LA, Goldberger AL, Ivanov P, Stanley HE: Scale-independent measures and pathologic cardiac dynamics. Phys Rev Lett 1998, 81: 2388-2391. 10.1103/PhysRevLett.81.2388
Iyengar N, Peng CK, Morin R, Goldberger AL, Lipsitz LA: Age-relatedalterations in the fractal scaling of cardiac interbeat interval dynamics. Am J Physiol 1996, 271: R1078-R1084.
Viswanathan GM, Peng CK, Stanley HE, Goldberger AL: Deviations fromuniform power law scaling in nonstationary time series. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 1997, 55: 845-849. 10.1103/PhysRevE.55.845
Mahon NG, Hedman AE, Padula M, Gang Y, Savelieva I, Waktare JE, Malik MM, Huikuri HV, McKenna WJ: Fractal correlation properties of R-R interval dynamics in asymptomatic relatives of patients with dilated cardiomyopathy. Eur J Heart Fail 2002, 4: 151-158. 10.1016/S1388-9842(01)00227-6
Makikallio TH, Ristimae T, Airaksinen KE, Peng CK, Goldberger AL, Huikuri HV: Heart rate dynamics in patients with stable angina pectorisand utility of fractal and complexity measures. Am J Cardiol 1998, 81: 27-31. 10.1016/S0002-9149(97)00799-6
Ho KK, Moody GB, Peng CK, Mietus JE, Larson MG, Levy D, Goldberger AL: Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics. Circulation 1997, 96: 842-848.
Makikallio TH, Koistinen J, Jordaens L, Tulppo MP, Wood N, Golosarsky B, Peng CK, Goldberger AL, Huikuri HV: Heart rate dynamics before spontaneous onset of ventricular fibrillation in patients with healed myocardial infarcts. Am J Cardiol 1999, 83: 880-884. 10.1016/S0002-9149(98)01068-6
Penzel T, Kantelhardt JW, Grote L, Peter JH, Bunde A: Comparison ofdetrended fluctuation analysis and spectral analysis for heart rate variability in sleep and sleep apnea. IEEE Trans Biomed Eng 2003, 50: 1143-1151. 10.1109/TBME.2003.817636
Tapanainen JM, Thomsen PE, Kober L, Torp-Pedersen C, Makikallio TH, Still AM, Lindgren KS, Huikuri HV: Fractal analysis of heart rate variability and mortality after an acute myocardial infarction. Am J Cardiol 2002, 90: 347-352. 10.1016/S0002-9149(02)02488-8
Laitio TT, Huikuri HV, Kentala ES, Makikallio TH, Jalonen JR, Helenius H, Sariola-Heinonen K, Yli-Mayry S, Scheinin H: Correlation properties and complexity of perioperative RR-interval dynamics in coronary artery bypass surgery patients. Anesthesiology 2000, 93: 69-80. 10.1097/00000542-200007000-00015
Peng CK, Mietus JE, Liu Y, Lee C, Hausdorff JM, Stanley HE, Goldberger AL, Lipsitz LA: Quantifying fractal dynamics of human respiration: age and gender effects. Ann Biomed Eng 2002, 30: 683-692. 10.1114/1.1481053
Cernelc M, Suki B, Reinmann B, Hall GL, Frey U: Correlation properties of tidal volume and end-tidal O2and CO2concentrations in healthy infants. J Appl Physiol 2002, 92: 1817-1827.
Varela M, Jimenez L, Farina R: Complexity analysis of the temperature curve: new information from body temperature. Eur J Appl Physiol 2003, 89: 230-237.
Hwa RC, Ferree TC: Scaling properties of fluctuations in the humanelectroencephalogram. Phys Rev E Stat Nonlin Soft Matter Phys 2002, 66: 021901. 10.1103/PhysRevE.66.021901
Shen Y, Olbrich E, Achermann P, Meier PF: Dimensional complexity and spectral properties of the human sleep EEG. Electroencephalograms. Clin Neurophysiol 2003, 114: 199-209. 10.1016/S1388-2457(02)00338-3
Goldberger AL, Amaral LA, Glass L, Hausdorff JM, Ivanov PC, Mark RG, Mietus JE, Moody GB, Peng CK, Stanley HE: PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource for complex physiologic signals. Circulation 2000, 101: E215-E220.
Willson K, Francis DP: A direct analytical demonstration of the essential equivalence of detrended fluctuation analysis and spectral analysis of RR interval variability. Physiol Meas 2003, 24: N1-N7. 10.1088/0967-3334/24/1/401
Ivanov PC, Amaral LA, Goldberger AL, Havlin S, Rosenblum MG, Struzik ZR, Stanley HE: Multifractality in human heartbeat dynamics. Nature 1999, 399: 461-465. 10.1038/20924
Echeverria JC, Woolfson MS, Crowe JA, Hayes-Gill BR, Croaker GD, Vyas H: Interpretation of heart rate variability via detrended fluctuation analysis and alphabeta filter. Chaos 2003, 13: 467-475. 10.1063/1.1562051
Richman JS, Moorman JR: Physiological time-series analysis using approximate entropy and sample entropy. Am J Physiol Heart Circ Physiol 2000, 278: H2039-H2049.
Pincus SM: Approximate entropy as a measure of system complexity. Proc Natl Acad Sci USA 1991, 88: 2297-2301.
Pincus SM, Goldberger AL: Physiological time-series analysis: what does regularity quantify? Am J Physiol 1994, 266: H1643-H1656.
Pincus S, Singer BH: Randomness and degrees of irregularity. Proc Natl Acad Sci USA 1996, 93: 2083-2088. 10.1073/pnas.93.5.2083
Pincus SM: Assessing serial irregularity and its implications for health. Ann N Y Acad Sci 2001, 954: 245-267.
Pincus S: Approximate entropy (ApEn) as a complexity measure. Chaos 1995, 5: 110-117. 10.1063/1.166092
Lipsitz LA, Goldberger AL: Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence. JAMA 1992, 267: 1806-1809. 10.1001/jama.267.13.1806
Goldberger AL, Peng CK, Lipsitz LA: What is physiologic complexity and how does it change with aging and disease? Neurobiol Aging 2002, 23: 23-26. 10.1016/S0197-4580(01)00266-4
Ryan SM, Goldberger AL, Pincus SM, Mietus J, Lipsitz LA: Gender- and age-related differences in heart rate dynamics: are women more complex than men? J Am Coll Cardiol 1994, 24: 1700-1707.
Vikman S, Makikallio TH, Yli-Mayry S, Pikkujamsa S, Koivisto AM, Reinikainen P, Airaksinen KE, Huikuri HV: Altered complexity and correlation properties of R-R interval dynamics before the spontaneous onset of paroxysmal atrial fibrillation. Circulation 1999, 100: 2079-2084.
Hogue CW Jr, Domitrovich PP, Stein PK, Despotis GD, Re L, Schuessler RB, Kleiger RE, Rottman JN: RR interval dynamics before atrial fibrillation in patients after coronary artery bypass graft surgery. Circulation 1998, 98: 429-434.
Schuckers SA: Use of approximate entropy measurements to classify ventricular tachycardia and fibrillation. J Electrocardiol 1998, Suppl: 101-105. 10.1016/S0022-0736(98)90300-4
Pincus SM, Cummins TR, Haddad GG: Heart rate control in normal andaborted-SIDS infants. Am J Physiol 1993, 264: R638-R646.
Fleisher LA, Pincus SM, Rosenbaum SH: Approximate entropy of heartrate as a correlate of postoperative ventricular dysfunction. Anesthesiology 1993, 78: 683-692.
Godin PJ, Fleisher LA, Eidsath A, Vandivier RW, Preas HL, Banks SM, Buchman TG, Suffredini AF: Experimental human endotoxemia increases cardiac regularity: results from a prospective, randomized, crossover trial. Crit Care Med 1996, 24: 1117-1124. 10.1097/00003246-199607000-00009
Hartman ML, Pincus SM, Johnson ML, Matthews DH, Faunt LM, Vance ML, Thorner MO, Veldhuis JD: Enhanced basal and disorderly growth hormone secretion distinguish acromegalic from normal pulsatile growth hormone release. J Clin Invest 1994, 94: 1277-1288.
van den Berg G, Pincus SM, Frolich M, Veldhuis JD, Roelfsema F: Reduced disorderliness of growth hormone release in biochemically inactive acromegaly after pituitary surgery. Eur J Endocrinol 1998, 138: 164-169. 10.1530/eje.0.1380164
Meneilly GS, Ryan AS, Veldhuis JD, Elahi D: Increased disorderliness of basal insulin release, attenuated insulin secretory burst mass, and reduced ultradian rhythmicity of insulin secretion in older individuals. J Clin Endocrinol Metab 1997, 82: 4088-4093. 10.1210/jc.82.12.4088
Schmitz O, Porksen N, Nyholm B, Skjaerbaek C, Butler PC, Veldhuis JD, Pincus SM: Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM. Am J Physiol 1997, 272: E218-E226.
Roelfsema F, Pincus SM, Veldhuis JD: Patients with Cushing's disease secrete adrenocorticotropin and cortisol jointly more asynchronously than healthy subjects. J Clin Endocrinol Metab 1998, 83: 688-692. 10.1210/jc.83.2.688
Veldman RG, Frolich M, Pincus SM, Veldhuis JD, Roelfsema F: Growth hormone and prolactin are secreted more irregularly in patients with Cushing's disease. Clin Endocrinol (Oxf) 2000, 52: 625-632. 10.1046/j.1365-2265.2000.00994.x
Prank K, Harms H, Dammig M, Brabant G, Mitschke F, Hesch RD: Is there low-dimensional chaos in pulsatile secretion of parathyroid hormone in normal human subjects? Am J Physiol 1994, 266: E653-E658.
Bruhn J, Ropcke H, Hoeft A: Approximate entropy as an electroencephalographic measure of anesthetic drug effect during desflurane anesthesia. Anesthesiology 2000, 92: 715-726. 10.1097/00000542-200003000-00016
Bruhn J, Bouillon TW, Shafer SL: Onset of propofol-induced burst suppression may be correctly detected as deepening of anaesthesia by approximate entropy but not by bispectral index. Br J Anaesth 2001, 87: 505-507. 10.1093/bja/87.3.505
Bruhn J, Bouillon TW, Radulescu L, Hoeft A, Bertaccini E, Shafer SL: Correlation of approximate entropy, bispectral index, and spectral edge frequency 95 (SEF95) with clinical signs of "anesthetic depth" during coadministration of propofol and remifentanil. Anesthesiology 2003, 98: 621-627. 10.1097/00000542-200303000-00008
Engoren M: Approximate entropy of respiratory rate and tidal volume during weaning from mechanical ventilation. Crit Care Med 1998, 26: 1817-1823.
Caldirola D, Bellodi L, Caumo A, Migliarese G, Perna G: Approximate entropy of respiratory patterns in panic disorder. Am J Psychiatry 2004, 161: 79-87. 10.1176/appi.ajp.161.1.79
Burioka N, Cornelissen G, Halberg F, Kaplan DT, Suyama H, Sako T, Shimizu E: Approximate entropy of human respiratory movement during eye-closed waking and different sleep stages. Chest 2003, 123: 80-86. 10.1378/chest.123.1.80
Lake DE, Richman JS, Griffin MP, Moorman JR: Sample entropy analysis of neonatal heart rate variability. Am J Physiol Regul Integr Comp Physiol 2002, 283: R789-R797.
Costa M, Goldberger AL, Peng CK: Multiscale entropy analysis of complex physiologic time series. Phys Rev Lett 2002, 89: 068102. 10.1103/PhysRevLett.89.068102
Costa M, Goldberger AL, Peng CK: Multiscale entropy to distinguish physiologic and synthetic RR time series. Comput Cardiol 2002, 29: 137-140.
Berger RD: Broken fractals: where's the break? J Cardiovasc Electrophysiol 2001, 12: 33-35. 10.1046/j.1540-8167.2001.00033.x
Goldberger AL: Fractal variability versus pathologic periodicity: complexity loss and stereotypy in disease. Perspect Biol Med 1997, 40: 543-561.
Vaillancourt DE, Newell KM: Changing complexity in human behavior and physiology through aging and disease. Neurobiol Aging 2002, 23: 1-11. 10.1016/S0197-4580(01)00310-4
Vaillancourt DE, Newell KM: Complexity in aging and disease: response to commentaries. Neurobiol Aging 2002, 23: 27-29. 10.1016/S0197-4580(01)00310-4
Taboada JA, Arcay B, Arias JE: Real time monitoring and analysis via the medical information bus, Part II. Med Biol Eng Comput 1997, 35: 535-539.
Taboada JA, Arcay B, Arias JE: Real time monitoring and analysis via the medical information bus, Part I. Med Biol Eng Comput 1997, 35: 528-534.
Goldstein B, McNames J, McDonald BA, Ellenby M, Lai S, Sun Z, Krieger D, Sclabassi RJ: Physiologic data acquisition system and database for the study of disease dynamics in the intensive care unit. Crit Care Med 2003, 31: 433-441. 10.1097/01.CCM.0000050285.93097.52
Kowallik P, Jacobi I, Jirmann A, Meesmann M, Schmidt M, Wirtz H: Breath-to-breath variability correlates with apnea-hypopnea index in obstructive sleep apnea. Chest 2001, 119: 451-459. 10.1378/chest.119.2.451
Fathizadeh P, Shoemaker WC, Wo CC, Colombo J: Autonomic activity in trauma patients based on variability of heart rate and respiratory rate. Crit Care Med 2004, 32: 1300-1305. 10.1097/01.CCM.0000127776.78490.E4
Garrard CS, Kontoyannis DA, Piepoli M: Spectral analysis of heart rate variability in the sepsis syndrome. Clin Auton Res 1993, 3: 5-13. 10.1007/BF01819137
Piepoli M, Garrard CS, Kontoyannis DA, Bernardi L: Autonomic control of the heart and peripheral vessels in human septic shock. Intensive Care Med 1995, 21: 112-119. 10.1007/BF01726532
Akay M, Mulder EJ: Effects of maternal alcohol intake on fractal properties in human fetal breathing dynamics. IEEE Trans Biomed Eng 1998, 45: 1097-1103. 10.1109/10.709552
Hausdorff JM, Ashkenazy Y, Peng CK, Ivanov PC, Stanley HE, Goldberger AL: When human walking becomes random walking: fractal analysis and modeling of gait rhythm fluctuations. Physica A 2001, 302: 138-147. 10.1016/S0378-4371(01)00460-5
Hausdorff JM, Cudkowicz ME, Firtion R, Wei JY, Goldberger AL: Gait variability and basal ganglia disorders: stride-to-stride variations of gait cycle timing in Parkinson's disease and Huntington's disease. Mov Disord 1998, 13: 428-437. 10.1002/mds.870130310
Hausdorff JM, Lertratanakul A, Cudkowicz ME, Peterson AL, Kaliton D, Goldberger AL: Dynamic markers of altered gait rhythm in amyotrophic lateral sclerosis. J Appl Physiol 2000, 88: 2045-2053.
van Emmerik RE, van Wegen EE: On the functional aspects of variability in postural control. Exerc Sport Sci Rev 2002, 30: 177-183. 10.1097/00003677-200210000-00007
Gottschalk A, Bauer MS, Whybrow PC: Evidence of chaotic mood variation in bipolar disorder. Arch Gen Psychiatry 1995, 52: 947-959.
Ehlers CL: Chaos and complexity. Can it help us to understand mood and behavior? Arch Gen Psychiatry 1995, 52: 960-964.
Maj M, Magliano L, Pirozzi R, Marasco C, Guarneri M: Validity of rapid cycling as a course specifier for bipolar disorder. Am J Psychiatry 1994, 151: 1015-1019.
Goldberger AL, Kobalter K, Bhargava V: 1/f-like scaling in normal neutrophil dynamics: implications for hematologic monitoring. IEEE Trans Biomed Eng 1986, 33: 874-876.
Haurie C, Person R, Dale DC, Mackey MC: Hematopoietic dynamics in grey collies. Exp Hematol 1999, 27: 1139-1148. 10.1016/S0301-472X(99)00051-X
Toweill D, Sonnenthal K, Kimberly B, Lai S, Goldstein B: Linear and nonlinear analysis of hemodynamic signals during sepsis and septic shock. Crit Care Med 2000, 28: 2051-2057. 10.1097/00003246-200006000-00063
Bruhn J, Lehmann LE, Ropcke H, Bouillon TW, Hoeft A: Shannon entropy applied to the measurement of the electroencephalographic effects of desflurane. Anesthesiology 2001, 95: 30-35. 10.1097/00000542-200107000-00010
Bruhn J, Ropcke H, Rehberg B, Bouillon T, Hoeft A: Electroencephalogram approximate entropy correctly classifies the occurrence of burst suppression pattern as increasing anesthetic drug effect. Anesthesiology 2000, 93: 981-985. 10.1097/00000542-200010000-00018