Deletion of Stat3 in hematopoietic cells enhances thrombocytosis and shortens survival in a JAK2-V617F mouse model of MPN

Blood - Tập 125 - Trang 2131-2140 - 2015
Jean Grisouard1, Takafumi Shimizu1, Adrian Duek1, Lucia Kubovcakova1, Hui Hao-Shen1, Stephan Dirnhofer2, Radek C. Skoda1
1Department of Biomedicine, Experimental Hematology, and Basel, Switzerland
2Institute of Pathology, University Hospital Basel, Basel, Switzerland

Tóm tắt

Key Points Loss of Stat3 in hematopoietic cells enhances JAK2-V617F–driven thrombopoiesis and negatively impacts survival in mouse models. The phenotypic changes of Stat3-deficient JAK2-V617F mice could in part be mediated by increased Stat1 expression and activation.

Tài liệu tham khảo

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