G Protein Pathways

American Association for the Advancement of Science (AAAS) - Tập 296 Số 5573 - Trang 1636-1639 - 2002
Susana R. Neves1, Prahlad T. Ram1, Ravi Iyengar1
1Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA

Tóm tắt

The heterotrimeric guanine nucleotide–binding proteins (G proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. The extracellular signals are received by members of a large superfamily of receptors with seven membrane-spanning regions that activate the G proteins, which route the signals to several distinct intracellular signaling pathways. These pathways interact with one another to form a network that regulates metabolic enzymes, ion channels, transporters, and other components of the cellular machinery controlling a broad range of cellular processes, including transcription, motility, contractility, and secretion. These cellular processes in turn regulate systemic functions such as embryonic development, gonadal development, learning and memory, and organismal homeostasis.

Từ khóa


Tài liệu tham khảo

10.1146/annurev.bi.49.070180.002533

10.1126/science.1902986

R. Iyengar D. Aaronson Gα i Pathway Science's STKE (Connections Map as seen May 2002) .

P. Ram R. Iyengar Gα s Pathway Science's STKE (Connections Map as seen May 2002) .

P. Ram R. Iyengar Gα q Pathway Science's STKE (Connections Map as seen May 2002) pathway. .

S. Neves P. Ram R. Iyengar Gα 12 Pathway Science's STKE (Connections Map as seen May 2002) .

S. Neves P. Ram R. Iyengar Gα 13 Pathway Science's STKE (Connections Map as seen May 2002) .

10.1038/284017a0

10.1016/0304-4157(90)90007-Y

R. Iyengar L. Birnbaumer Eds. G Proteins (Academic Press New York 1990).

10.1038/333129a0

10.1038/349117a0

10.1016/0092-8674(95)90407-7

10.1074/jbc.273.2.669

10.1038/175169a0

10.1016/S0021-9258(18)65911-3

10.1016/S0021-9258(18)62390-7

10.1016/S0021-9258(19)66920-6

10.1038/35073073

10.1016/S1097-2765(01)00432-4

B. Zheng et al. Science 294 1939 (2001).

10.1074/jbc.M109751200

10.1074/jbc.M101043200

Y. Jiang et al. Nature 395 808 (1998).

Chan A. M., et al., Mol. Cell. Biol. 13, 762 (1993).

We thank the reviewers for comments that were valuable in revising the paper. Research in our laboratory is supported by NIH grants GM-54508 DK-38761 and CA-81050. S.R.N. is supported by a predoctoral individual NRSA award F31GM65065.

Thông tin
Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 296 Số 5573

1636-1639

Thông tin tác giả