Fructose, weight gain, and the insulin resistance syndrome,,

Grundy, 1998, Multifactorial causation of obesity: implications for prevention, Am J Clin Nutr, 67, 563S, 10.1093/ajcn/67.3.563S Kuczmarski, 1994, Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991, JAMA, 272, 205, 10.1001/jama.1994.03520030047027 Hill, 1998, Environmental contributions to the obesity epidemic, Science, 280, 1371, 10.1126/science.280.5368.1371 Wickelgren, 1998, Obesity: how big a problem?, Science, 280, 1364, 10.1126/science.280.5368.1364 Kissebah, 1982, Relation of body fat distribution to metabolic complications of obesity, J Clin Endocrinol Metab, 54, 254, 10.1210/jcem-54-2-254 Reaven, 1988, Banting lecture 1988. Role of insulin resistance in human disease, Diabetes, 37, 1595, 10.2337/diab.37.12.1595 Purnell, 1997, The central role of dietary fat, not carbohydrate, in the insulin resistance syndrome, Curr Opin Lipidol, 8, 17, 10.1097/00041433-199702000-00005 Reaven, 1993, Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles, J Clin Invest, 92, 141, 10.1172/JCI116541 Reaven, 1995, Pathophysiology of insulin resistance in human disease, Physiol Rev, 75, 473, 10.1152/physrev.1995.75.3.473 Reaven, 1997, Do high carbohydrate diets prevent the development or attenuate the manifestations (or both) of syndrome X? A viewpoint strongly against, Curr Opin Lipidol, 8, 23, 10.1097/00041433-199702000-00006 Havel, 2002, Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin, Curr Opin Lipidol, 13, 51, 10.1097/00041433-200202000-00008 Rask, 2001, Tissue-specific dysregulation of cortisol metabolism in human obesity, J Clin Endocrinol Metab, 86, 1418, 10.1210/jcem.86.3.7453 Masuzaki, 2001, A transgenic model of visceral obesity and the metabolic syndrome, Science, 294, 2166, 10.1126/science.1066285 Meigs, 1997, Risk variable clustering in the insulin resistance syndrome. The Framingham Offspring Study, Diabetes, 46, 1594, 10.2337/diacare.46.10.1594 Hill, 1992, Development of dietary obesity in rats: influence of amount and composition of dietary fat, Int J Obes Relat Metab Disord, 16, 321 Romieu, 1988, Energy intake and other determinants of relative weight, Am J Clin Nutr, 47, 406, 10.1093/ajcn/47.3.406 Feskens, 1995, Dietary factors determining diabetes and impaired glucose tolerance. A 20-year follow-up of the Finnish and Dutch cohorts of the Seven Countries Study, Diabetes Care, 18, 1104, 10.2337/diacare.18.8.1104 Kromhout, 1995, Dietary saturated and trans fatty acids and cholesterol and 25-year mortality from coronary heart disease: the Seven Countries Study, Prev Med, 24, 308, 10.1006/pmed.1995.1049 Putnam, 1999 Bhosale, 1996, Molecular and industrial aspects of glucose isomerase, Microbiol Rev, 60, 280, 10.1128/mr.60.2.280-300.1996 Park, 1993, Intakes and food sources of fructose in the United States, Am J Clin Nutr, 58, 737S, 10.1093/ajcn/58.5.737S Guzman-Maldonado, 1995, Amylolytic enzymes and products derived from starch: a review, Crit Rev Food Sci Nutr, 35, 373, 10.1080/10408399509527706 Mayes, 1993, Intermediary metabolism of fructose, Am J Clin Nutr, 58, 754S, 10.1093/ajcn/58.5.754S Shiota, 1998, Small amounts of fructose markedly augment net hepatic glucose uptake in the conscious dog, Diabetes, 47, 867, 10.2337/diabetes.47.6.867 Petersen, 2001, Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans, Diabetes, 50, 1263, 10.2337/diabetes.50.6.1263 Hawkins, 1999, Fructose restores the ability of hyperglycemia per se to regulate hepatic glucose production (GP) in type 2 diabetes mellitus (DM2), Diabetes, 48, A292 Moore, 2000, Fructose decreases the glucose and insulin responses to an oral glucose tolerance test (OGTT) in individuals with type 2 diabetes (DM2), Diabetes, 49, A84 Glinsmann, 1993, The public health significance of dietary fructose, Am J Clin Nutr, 58, 820S, 10.1093/ajcn/58.5.820S Schwarz, 1993, De novo lipogenesis during fasting and oral fructose ingestion in lean and obese hyperinsulinemic subjects, Diabetes, 42, A39 Schwarz, 1994, Effect of fructose ingestion on glucose production (GP) and de novo lipogenesis (DNL) in normal and hyperinsulinemic obese humans, Diabetes, 43, 52A Hellerstein, 1996, Regulation of hepatic de novo lipogenesis in humans, Annu Rev Nutr, 16, 523, 10.1146/annurev.nu.16.070196.002515 Jeppesen, 1995, Postprandial triglyceride and retinyl ester responses to oral fat: effects of fructose, Am J Clin Nutr, 61, 787, 10.1093/ajcn/61.4.787 Abraha, 1998, Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjects, Br J Nutr, 80, 169, 10.1017/S000711459800107X Kanarek, 1982, Differential effects of sucrose, fructose and glucose on carbohydrate-induced obesity in rats, J Nutr, 112, 1546, 10.1093/jn/112.8.1546 Rizkalla, 1993, Effects of chronic dietary fructose with and without copper supplementation on glycaemic control, adiposity, insulin binding to adipocytes and glomerular basement membrane thickness in normal rats, Br J Nutr, 70, 199, 10.1079/BJN19930117 Kasim-Karakas, 1996, Effects of dietary carbohydrates on glucose and lipid metabolism in golden Syrian hamsters, J Lab Clin Med, 128, 208, 10.1016/S0022-2143(96)90013-X Tordoff, 1990, Effect of drinking soda sweetened with aspartame or high-fructose corn syrup on food intake and body weight, Am J Clin Nutr, 51, 963, 10.1093/ajcn/51.6.963 Anderson, 1989, Metabolic effects of fructose supplementation in diabetic individuals, Diabetes Care, 12, 337, 10.2337/diacare.12.5.337 Astrup, 2002, Sucrose in soft drinks is fattening: a randomized 10 week study in overweight subjects, Am J Clin Nutr, 75, 405S Grant, 1980, Insulin release from human pancreatic islets in vitro, Diabetologia, 19, 114, 10.1007/BF00421856 Curry, 1989, Effects of mannose and fructose on the synthesis and secretion of insulin, Pancreas, 4, 2, 10.1097/00006676-198902000-00002 Sato, 1996, Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets, Tissue Cell, 28, 637, 10.1016/S0040-8166(96)80067-X Woods, 1996, The evaluation of insulin as a metabolic signal influencing behavior via the brain, Neurosci Biobehav Rev, 20, 139, 10.1016/0149-7634(95)00044-F Schwartz, 2000, Central nervous system control of food intake, Nature, 404, 661, 10.1038/35007534 Kaiyala, 2000, Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs, Diabetes, 49, 1525, 10.2337/diabetes.49.9.1525 Brüning, 2000, Role of brain insulin receptor in control of body weight and reproduction, Science, 289, 2122, 10.1126/science.289.5487.2122 Schwartz, 1995, Reduced insulin secretion: an independent predictor of body weight gain, J Clin Endocrinol Metab, 80, 1571 Zhang, 1994, Positional cloning of the mouse obese gene and its human homologue, Nature, 372, 425, 10.1038/372425a0 Masuzaki, 1995, Human obese gene expression. Adipocyte-specific expression and regional differences in adipose tissue, Diabetes, 44, 855, 10.2337/diab.44.7.855 Caro, 1996, Leptin: the tale of an obesity gene, Diabetes, 45, 1455, 10.2337/diab.45.11.1455 Rohner-Jeanrenaud, 1996, Obesity, leptin, and the brain, N Engl J Med, 334, 324, 10.1056/NEJM199602013340511 Niswender, 2001, Intracellular signalling. Key enzyme in leptin-induced anorexia, Nature, 413, 794, 10.1038/35101657 Haynes, 1997, Receptor-mediated regional sympathetic nerve activation by leptin, J Clin Invest, 100, 270, 10.1172/JCI119532 Havel, 1997, Acute adrenergically-mediated increases of circulating glucose and lactate after leptin administration in rhesus monkeys, Obes Res, 5, 17S Tang-Christensen, 1999, Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques, J Clin Endocrinol Metab, 84, 711 Montague, 1997, Congenital leptin deficiency is associated with severe early-onset obesity in humans, Nature, 387, 903, 10.1038/43185 Clement, 1998, A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction, Nature, 392, 398, 10.1038/32911 Farooqi, 1999, Effects of recombinant leptin therapy in a child with congenital leptin deficiency, N Engl J Med, 341, 879, 10.1056/NEJM199909163411204 Farooqi, 2001, Partial leptin deficiency and human adiposity, Nature, 414, 34, 10.1038/35102112 Keim, 1998, Relation between circulating leptin concentrations and appetite during a prolonged, moderate energy deficit in women, Am J Clin Nutr, 68, 794, 10.1093/ajcn/68.4.794 Westerterp-Plantenga, 2001, Effects of weekly administration of pegylated recombinant human OB protein on appetite profile and energy metabolism in obese men, Am J Clin Nutr, 74, 426, 10.1093/ajcn/74.4.426 Havel, 1998, Leptin production and action: relevance to energy balance in humans, Am J Clin Nutr, 67, 355, 10.1093/ajcn/67.3.355 Ahren, 1997, Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting, Am J Physiol, 273, R113 Maffei, 1995, Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight reduced subjects, Nat Med, 1, 1155, 10.1038/nm1195-1155 Havel, 1997, Glucose but not fructose infusion increases circulating leptin in proportion to adipose stores in rhesus monkeys, Exp Clin Endocrinol Diabetes, 105, 37, 10.1055/s-0029-1211853 Havel, 1996, Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss, J Clin Endocrinol Metab, 81, 4406 Weigle, 1997, Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels, J Clin Endocrinol Metab, 82, 561 Dubuc, 1998, Changes of serum leptin and endocrine and metabolic parameters after 7 days of energy restriction in men and women, Metabolism, 47, 429, 10.1016/S0026-0495(98)90055-5 Havel, 2001, Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis, Exp Biol Med, 226, 963, 10.1177/153537020122601102 Sinha, 1996, Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects, J Clin Invest, 97, 1344, 10.1172/JCI118551 Schoeller, 1997, Entrainment of the diurnal rhythm of plasma leptin to meal timing, J Clin Invest, 100, 1882, 10.1172/JCI119717 Boden, 1996, Effect of fasting on serum leptin in normal human subjects, J Clin Endocrinol Metab, 81, 3419 Saad, 1998, Physiological insulinemia acutely modulates plasma leptin, Diabetes, 47, 544, 10.2337/diabetes.47.4.544 Mueller, 1998, Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes, Endocrinology, 139, 551, 10.1210/endo.139.2.5716 Moreno-Aliaga, 2001, Transcriptional regulation of the leptin promoter by insulin-stimulated glucose metabolism in 3t3-l1 adipocytes, Biochem Biophys Res Comm, 283, 544, 10.1006/bbrc.2001.4822 Mueller, 2000, Effects of metformin and vanadium on leptin secretion from cultured rat adipocytes, Obes Res, 8, 530, 10.1038/oby.2000.66 Wellhoener, 2000, Glucose metabolism rather than insulin is a main determinant of leptin secretion in humans, J Clin Endocrinol Metab, 85, 1267, 10.1210/jcem.85.3.6483 Laughlin, 1997, Hypoleptinemia in women athletes: absence of a diurnal rhythm with amenorrhea, J Clin Endocrinol Metab, 82, 318, 10.1210/jcem.82.1.3840 Saad, 1998, Diurnal and ultradian rhythmicity of plasma leptin: effects of gender and adiposity, J Clin Endocrinol Metab, 83, 453 Havel, 1999, High fat meals reduce 24-hour circulating leptin concentrations in women, Diabetes, 48, 334, 10.2337/diabetes.48.2.334 Poppitt, 2002, Long-term effects of ad libitum low-fat, high-carbohydrate diets on body weight and serum lipids in overweight subjects with metabolic syndrome, Am J Clin Nutr, 75, 11, 10.1093/ajcn/75.1.11 Horton, 1995, Fat and carbohydrate overfeeding in humans: different effects on energy storage, Am J Clin Nutr, 62, 19, 10.1093/ajcn/62.1.19 Tataranni, 1997, Effect of fat intake on energy balance, Ann N Y Acad Sci, 819, 37, 10.1111/j.1749-6632.1997.tb51797.x Tremblay, 1989, Impact of dietary fat content and fat oxidation on energy intake in humans, Am J Clin Nutr, 49, 799, 10.1093/ajcn/49.5.799 Havel, 2002, Consuming high fructose meals reduces 24 hour circulating insulin and leptin concentrations and does not suppress circulating ghrelin in women, J Invest Med, 50, 26A Tschop, 2001, Circulating ghrelin levels are decreased in human obesity, Diabetes, 50, 707, 10.2337/diabetes.50.4.707 Hallfrisch, 1979, Insulin and glucose responses in rats fed sucrose or starch, Am J Clin Nutr, 32, 787, 10.1093/ajcn/32.4.787 Reiser, 1977, Insulin sensitivity and adipose tissue weight of rats fed starch or sucrose diets ad libitum or in meals, J Nutr, 107, 147, 10.1093/jn/107.1.147 Zavaroni, 1980, Effect of fructose feeding on insulin secretion and insulin action in the rat, Metabolism, 29, 970, 10.1016/0026-0495(80)90041-4 Martinez, 1994, High-fructose feeding elicits insulin resistance, hyperinsulinism, and hypertension in normal mongrel dogs, Hypertension, 23, 456, 10.1161/01.HYP.23.4.456 Thorburn, 1989, Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats, Am J Clin Nutr, 49, 1155, 10.1093/ajcn/49.6.1155 Fields, 1996, Responses of insulin to oral glucose and fructose loads in marginally copper-deficient rats fed starch or fructose, Nutrition, 12, 524, 10.1016/S0899-9007(96)91730-X Blakely, 1981, Long-term effects of moderate fructose feeding on glucose tolerance parameters in rats, J Nutr, 111, 307, 10.1093/jn/111.2.307 Beck-Nielsen, 1980, Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects, Am J Clin Nutr, 33, 273, 10.1093/ajcn/33.2.273 Hallfrisch, 1983, Effects of dietary fructose on plasma glucose and hormone responses in normal and hyperinsulinemic men, J Nutr, 113, 1819, 10.1093/jn/113.9.1819 McGarry, 1994, Disordered metabolism in diabetes: have we underemphasized the fat component?, J Cell Biochem, 55, 29, 10.1002/jcb.240550005 Jéquier, 1999, Regulation of body weight in humans, Physiol Rev, 79, 451, 10.1152/physrev.1999.79.2.451 Virkamäki, 2001, Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle, Diabetes, 50, 2337, 10.2337/diabetes.50.10.2337 Rebrin, 1995, Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin, Diabetes, 44, 1038, 10.2337/diab.44.9.1038 Steil, 1998, Role of portal insulin delivery in the disappearance of intravenous glucose and assessment of insulin sensitivity, Diabetes, 47, 714, 10.2337/diabetes.47.5.714 Bergman, 2000, Free fatty acids and pathogenesis of type 2 diabetes mellitus, Trends Endocrinol Metab, 11, 351, 10.1016/S1043-2760(00)00323-4 Arner, 2001, Free fatty acids—do they play a central role in type 2 diabetes?, Diabetes Obes Metab, 3, S11, 10.1046/j.1463-1326.2001.00031.x Bieger, 1984, Diminished insulin receptors on monocytes and erythrocytes in hypertriglyceridemia, Metabolism, 33, 982, 10.1016/0026-0495(84)90224-5 Storlien, 1993, Syndromes of insulin resistance in the rat. Inducement by diet and amelioration with benfluorex, Diabetes, 42, 457, 10.2337/diab.42.3.457 Jeng, 1996, Gemfibrozil treatment of endogenous hypertriglyceridemia: effect on insulin-mediated glucose disposal and plasma insulin concentrations, J Clin Endocrinol Metab, 81, 2550 Weyer, 2001, Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia, J Clin Endocrinol Metab, 86, 1930, 10.1210/jcem.86.5.7463 Herman, 1970, Effect of diet on lipid metabolism in experimental animals and man, Fed Proc, 29, 1302 Inoue, 1995, Effect of troglitazone (CS-045) and bezafibrate on glucose tolerance, liver glycogen synthase activity, and beta-oxidation in fructose-fed rats, Metabolism, 44, 1626, 10.1016/0026-0495(95)90085-3 Okazaki, 1994, Correlation between plasma fibrinogen and serum lipids in rats with hyperlipidemia induced by cholesterol free-high fructose or high cholesterol diet, J Nutr Sci Vitaminol (Tokyo), 40, 479, 10.3177/jnsv.40.479 Fields, 1999, Dietary fructose but not starch is responsible for hyperlipidemia associated with copper deficiency in rats: effect of high-fat diet, J Am Coll Nutr, 18, 83, 10.1080/07315724.1999.10718831 Hellerstein, 1996, Synthesis of fat in response to alterations in diet: insights from new stable isotope methodologies, Lipids, 31, S117, 10.1007/BF02637062 Schwarz, 1993, Effect of oral fructose on lipolysis, fat oxidation, fractional and absolute de novo lipogenesis (DNL) using mass isotopomer distribution analysis (MIDA), FASEB J, 7, A867 Reiser, 1985, Effects of dietary sugars in metabolic risk factors associated with heart disease, Nutr Health, 3, 203 Hallfrisch, 1983, Blood lipid distribution of hyperinsulinemic men consuming three levels of fructose, Am J Clin Nutr, 37, 740, 10.1093/ajcn/37.5.740 Reiser, 1989, Day-long glucose, insulin, and fructose responses of hyperinsulinemic and nonhyperinsulinemic men adapted to diets containing either fructose or high-amylose cornstarch, Am J Clin Nutr, 50, 1008, 10.1093/ajcn/50.5.1008 Huttunen, 1976, Turku sugar studies XI. Effects of sucrose, fructose and xylitol diets on glucose, lipid and urate metabolism, Acta Odontol Scand, 34, 345, 10.3109/00016357609004646 Hollenbeck, 1993, Dietary fructose effects on lipoprotein metabolism and risk for coronary artery disease, Am J Clin Nutr, 58, 800S, 10.1093/ajcn/58.5.800S Bantle, 2000, Effects of dietary fructose on plasma lipids in healthy subjects, Am J Clin Nutr, 72, 1128, 10.1093/ajcn/72.5.1128 Teff, 2002, Consuming high fructose meals reduces 24 hour plasma insulin and leptin concentrations, does not suppress circulating ghrelin, and increases postprandial and fasting triglycerides in women, Diabetes, 1, 1672 Parks, 2000, Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms, Am J Clin Nutr, 71, 412, 10.1093/ajcn/71.2.412 Taghibiglou, 2000, J Biol Chem, 275, 8416, 10.1074/jbc.275.12.8416 Farris, 1998, Nutrient intake and food group consumption of 10-year-olds by sugar intake level: the Bogalusa Heart Study, J Am Coll Nutr, 17, 579, 10.1080/07315724.1998.10718806 Dwyer, 2001, Adolescents’ eating patterns influence their nutrient intakes, J Am Diet Assoc, 101, 798, 10.1016/S0002-8223(01)00198-5 Cavadini, 2000, US adolescent food intake trends from 1965 to 1996, Arch Dis Child, 83, 18, 10.1136/adc.83.1.18 Dai, 1995, Fructose-induced hypertension in rats is concentration- and duration-dependent, J Pharmacol Toxicol Methods, 33, 101, 10.1016/1056-8719(94)00063-A Erlich, 1995, Effect of angiotensin-converting enzyme inhibitors on fructose induced hypertension and hyperinsulinaemia in rats, Clin Exp Pharmacol Physiol, 22, S347, 10.1111/j.1440-1681.1995.tb02949.x Suzuki, 1997, Effect of an insulin sensitizer, pioglitazone, on hypertension in fructose-drinking rats, Jpn J Pharmacol, 74, 297, 10.1016/S0021-5198(19)31362-9 Verma, 1994, Antihypertensive effects of metformin in fructose-fed hyperinsulinemic, hypertensive rats, J Pharmacol Exp Ther, 271, 1334 Daly, 1997, Dietary carbohydrates and insulin sensitivity: a review of the evidence and clinical implications, Am J Clin Nutr, 66, 1072, 10.1093/ajcn/66.5.1072 Vasdev, 1998, Role of aldehydes in fructose induced hypertension, Mol Cell Biochem, 181, 1, 10.1023/A:1006844222963 Verma, 1996, Decreased vascular reactivity in metformin-treated fructose-hypertensive rats, Metabolism, 45, 1053, 10.1016/S0026-0495(96)90000-1 Takagawa, 2001, Long-term fructose feeding impairs vascular relaxation in rat mesenteric arteries, Am J Hypertens, 14, 811, 10.1016/S0895-7061(01)01298-5 Giacchetti, 2000, The tissue renin-angiotensin system in rats with fructose-induced hypertension: overexpression of type 1 angiotensin II receptor in adipose tissue, J Hypertens, 18, 695, 10.1097/00004872-200018060-00006 Coulston, 2002, Sugar and sugars: myths and realities, J Am Diet Assoc, 102, 351, 10.1016/S0002-8223(02)90082-9