Multiple lineages of monkeypox virus detected in the United States, 2021–2022

American Association for the Advancement of Science (AAAS) - Tập 378 Số 6619 - Trang 560-565 - 2022
Crystal M. Gigante1, Bette Korber2,3, Matthew H. Seabolt4,1, Kimberly Wilkins1, Whitni Davidson1, Agam K. Rao1, Hui Zhao1, Thomas A. Smith1, Christine M. Hughes1, Faisal S. Minhaj1, Michelle A. Waltenburg1, James Theiler5, Sandra Smole6, Glen R. Gallagher6, David Blythe7, Robert Myers7, Joann Schulte8, Joey Stringer8, Philip Lee9, Rafael Mendoza10, LaToya A. Griffin-Thomas11, Jenny Crain12, Jade Murray13, Annette Atkinson13, Anthony H. Gonzalez14, June Nash14, Dhwani Batra1, Inger K. Damon1, Jennifer H. McQuiston1, Christina L. Hutson1, Andrea M. McCollum1, Yu Li1
1National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
2New Mexico Consortium, Los Alamos, NM, USA
3T-6: Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, USA; New Mexico Consortium, Los Alamos, NM, USA.
4Leidos, Inc., Reston, VA 20190, USA
5ISR-3: Space Data Science and Systems, Los Alamos National Laboratory, Los Alamos, NM, USA.
6Massachusetts Department of Public Health, Jamaica Plain, MA, USA.
7Infectious Disease Epidemiology and Outbreak Response Bureau, Maryland Department of Health, Baltimore, MD, USA.
8Dallas County Health and Human Services Public Health Laboratory, Dallas, Texas, USA.
9Florida Department of Health Bureau of Public Health Laboratories-Jacksonville, Jacksonville, FL, USA.
10Florida Department of Health in Broward County, Hollywood, FL, USA.
11Virginia Department of General Services, Division of Consolidated Laboratory Services, Richmond, VA, USA.
12Virginia Department of Health, Richmond, VA, USA
13Utah Department of Health and Human Services, Salt Lake City, UT, USA
14Sacramento County Public Health, Sacramento, CA, USA.

Tóm tắt

Monkeypox is a viral zoonotic disease endemic in Central and West Africa. In May 2022, dozens of non-endemic countries reported hundreds of monkeypox cases, most with no epidemiological link to Africa. We identified two lineages of monkeypox virus (MPXV) among two 2021 and seven 2022 US monkeypox cases: the major 2022 outbreak variant called B.1 and a minor contemporaneously sampled variant called A.2. Analyses of mutations among these two variants revealed an extreme preference for GA-to-AA mutations indicative of human APOBEC3 cytosine deaminase activity among Clade IIb MPXV (previously West African, Nigeria) sampled since 2017. Such mutations were not enriched within other MPXV clades. These findings suggest that APOBEC3 editing may be a recurrent and a dominant driver of MPXV evolution within the current outbreak.

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Tài liệu tham khảo

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American Association for the Advancement of Science (AAAS)

Tập 378 Số 6619

560-565

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