Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia

Blood - Tập 130 Số 21 - Trang 2317-2325 - 2017
Karen Thudium Mueller1, Shannon L. Maude2, David L. Porter2, Noelle V. Frey2, Patricia A. Wood1, Xia Han1, Edward Waldron1, Abhijit Chakraborty1, Rakesh Awasthi1, Bruce L. Levine2, J. Joseph Melenhorst2, Stephan A. Grupp2, Carl H. June2, Simon F. Lacey2
1Novartis Pharmaceuticals Corporation, East Hanover, NJ
2Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

Tóm tắt

Key Points Tisagenlecleucel (CTL019) has demonstrated clinical efficacy in relapsed/refractory B-cell ALL and CLL. The cellular kinetic profile of tisagenlecleucel was consistent across the 2 diseases, with higher exposure in responding vs nonresponding patients.

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