Activation of astrocytes in the spinal cord contributes to the development of bilateral allodynia after peripheral nerve injury in rats

Araque, 1999, Tripartite synapses: glia, the unacknowledged partner, Trends Neurosci., 22, 208, 10.1016/S0166-2236(98)01349-6 Chaplan, 1994, Quantitative assessment of tactile allodynia in the rat paw, J. Neurosci. Meth., 53, 55, 10.1016/0165-0270(94)90144-9 Colburn, 1997, Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat, J. Neuroimmunol., 79, 163, 10.1016/S0165-5728(97)00119-7 DeLeo, 2004, Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia, Neuroscientist, 10, 40, 10.1177/1073858403259950 DeLeo, 1987, Ischemia-induced neuronal cell death, calcium accumulation, and glial response in the hippocampus of the Mongolian gerbil and protection by propentofylline (HWA 285), J. Cereb. Blood Flow Metab., 7, 745, 10.1038/jcbfm.1987.129 Echeverry, 2008, Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain, Pain, 135, 37, 10.1016/j.pain.2007.05.002 Finnerup, 2005, Algorithm for neuropathic pain treatment: an evidence based proposal, Pain, 118, 289, 10.1016/j.pain.2005.08.013 Fukuoka, 2001, Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal serve ligation model, J. Neurosci., 21, 4891, 10.1523/JNEUROSCI.21-13-04891.2001 Ito, 2009, Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model: comparison with a neuropathic pain model, Anesthesiology, 111, 640, 10.1097/ALN.0b013e3181b05f42 Kawasaki, 2008, Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain, Nat. Med., 14, 331, 10.1038/nm1723 Kim, 1992, An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat, Pain, 50, 355, 10.1016/0304-3959(92)90041-9 Meskini, 1994, Phosphodiesterase inhibitory profile of some related xanthine derivatives pharmacologically active on the peripheral microcirculation, Biochem. Pharmacol., 47, 781, 10.1016/0006-2952(94)90477-4 Milligan, 2001, Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines, J. Neurosci., 21, 2808, 10.1523/JNEUROSCI.21-08-02808.2001 Milligan, 2003, Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats, J. Neurosci., 23, 1026, 10.1523/JNEUROSCI.23-03-01026.2003 Milligan, 2009, Pathological and protective roles of glia in chronic pain, Nat. Rev. Neurosci., 10, 23, 10.1038/nrn2533 Nagata, 1985, In vitro and in vivo inhibitory effects of propentofylline on cyclic AMP phosphodiesterase activity, Arzneimittelforschung, 35, 1034 Parkinson, 1991, Effects of propentofylline on adenosine A1 and A2 receptors and nitrobenzylthioinosine-sensitive nucleoside transporters: quantitative autoradiographic analysis, Eur. J. Pharmacol., 202, 361, 10.1016/0014-2999(91)90279-Y Raghavendra, 2002, The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats, J. Neurosci., 22, 9980, 10.1523/JNEUROSCI.22-22-09980.2002 Raghavendra, 2003, Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy, J. Pharmacol. Exp. Ther., 306, 624, 10.1124/jpet.103.052407 Raghavendra, 2003, Antihyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines, Pain, 104, 655, 10.1016/S0304-3959(03)00138-6 Raghavendra, 2004, Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS, Eur. J. Neurosci., 20, 467, 10.1111/j.1460-9568.2004.03514.x Raghavendra, 2004, Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats, Neuropsychopharmacology, 29, 327, 10.1038/sj.npp.1300315 Si, 1996, Adenosine and propentofylline inhibit the proliferation of cultured microglial cells, Exp. Neurol., 137, 345, 10.1006/exnr.1996.0035 Spataro, 2004, Spinal gap junctions: potential involvement in pain facilitation, J. Pain, 5, 392, 10.1016/j.jpain.2004.06.006 Sweitzer, 1999, Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat, Brain Res., 829, 209, 10.1016/S0006-8993(99)01326-8 Sweitzer, 2001, Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain, J. Pharmacol. Exp. Ther., 297, 1210 Tanga, 2004, Quantitative real-time RT–PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain, Neurochem. Int., 45, 397, 10.1016/j.neuint.2003.06.002 Tawfik, 2006, Induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: heterogeneity of the differentiated phenotype, Glia, 54, 193, 10.1002/glia.20365 Tawfik, 2007, Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury, Brain Behav. Immun., 21, 238, 10.1016/j.bbi.2006.07.001 Watkins, 2001, Glial activation: a driving force for pathological pain, Trends Neurosci., 24, 450, 10.1016/S0166-2236(00)01854-3 Wei, 2008, Supraspinal glial–neuronal interactions contribute to descending pain facilitation, J. Neurosci., 28, 10482, 10.1523/JNEUROSCI.3593-08.2008 Winkelstein, 2002, Nerve root injury severity differentially modulates spinal glial activation in a rat lumbar radiculopathy model: considerations for persistent pain, Brain Res., 956, 294, 10.1016/S0006-8993(02)03560-6 Zhuang, 2006, A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance, J. Neurosci., 26, 3551, 10.1523/JNEUROSCI.5290-05.2006