Esen Sefik1, Naama Geva‐Zatorsky1, Sungwhan F. Oh1, Liza Konnikova2, David Zemmour1, Abigail L. Manson3, Dalia Burzyn1, Adriana Ortiz-Lopez1, Mercedes Lobera4, Jianfei Yang4, Shomir Ghosh4, Ashlee M. Earl3, Scott B. Snapper2, Ray Jupp5, Dennis L. Kasper1, Diane Mathis1,6, Christophe Benoist1,6
1Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston 02115, MA, USA.
2Division of Gastroenterology and Hepatology, Brigham and Women's Hospital, Boston, MA 02115, USA, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
4Tempero Pharmaceuticals, a GSK Company, Cambridge, MA 02115, USA.
5UCB Pharma, Slough, Berkshire, UK.
6Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA 02115, USA
Tóm tắt
Gut microbes make T cells keep the peace
Our guts harbor trillions of microbial inhabitants, some of which regulate the types of immune cells that are present in the gut. For instance,
Clostridium
species of bacteria induce a type of T cell that promotes tolerance between the host and its microbial contents. Ohnmacht
et al.
and Sefik
et al.
characterized a population of gut regulatory T cells in mice, which required gut microbiota to survive. Multiple bacterial species of the microbiota could induce transcription factor–expressing regulatory T cells that helped maintain immune homeostasis. Mice engineered to lack these transcription factors exhibited enhanced susceptibility to colonic inflammation and had elevated amounts of proinflammatory molecules associated with allergies (see the Perspective by Hegazy and Powrie).
Science
, this issue pp.
989
and
993
